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Journal of Traditional Chinese Medicine >

2025 , Vol. 45 >Issue 5: 1040 - 1047

DOI: https://doi.org/10.19852/j.cnki.jtcm.2025.05.010

Original Articles

Effect of Jiegeng (Radix Platycodi) on Jingjie (Herba Schizonepetae Tenuifoliae) “Yin-Jing” into the lungs based on pharmacokinetics

  • Yuanmei ZHANG ,
  • Heqing LIU ,
  • Shaowen WANG ,
  • Lele WANG ,
  • Yawen GAO ,
  • Rui SUN ,
  • Jihui TANG
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  • 1 School of Pharmacy, Anhui Medical University, Hefei 230032, China
    2 Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Research and Industrialization of New Drug Release Technology Joint Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei 230032, China

Received date: 2024-09-02

  Accepted date: 2025-01-13

  Online published: 2025-09-15

Supported by

Key Laboratory of Xin’an Medicine Open Project Fund (Anhui University of Chinese Medicine) Ministry of Education: Study on the Material Basis and Mechanism of the Buoyance of Jingjie (Herba Schizonepetae Tenuifoliae) Loaded with Jiegeng (Radix Platycodi) of Traditional Chinese Medicine(2020xayx02);Drug Regulatory Scientific Research Key Project: Establishment of a New Dissolution Method Based on Drug Absorption and its Application in Drug Quality Monitoring (AHYJ-KJ-202206, Central of Regulatory Science for Medical Products, Anhui Province);Anhui Provincial Natural Science Foundation of Anhui Province of China: to Explore the Effect and Mechanism of Immune Escape Nanopreparation Based on "Dont eat me" Signal on Tumor Photodynamic Therapy(2308085MH308)

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Abstract

OBJECTIVE: To investigate whether Jiegeng (Radix Platycodi, RP) has a Yin-Jing potentiating effect on Jingjie (Herba Schizonepetae Tenuifoliae,ST). We investigated the pharmacokinetics and tissue distribution of pulegone, the active ingredient in ST volatile oil, in rats to verify the scientific validity of the Yin-Jing doctrine, the basic theory of Traditional Chinese Medicine (TCM).

METHODS: The volatile oil and aqueous extract of ST were extracted by hydrodistillation. RP's aqueous extract underwent aqueous extraction. After individual and co-administration, we conducted pharmacokinetic and tissue distribution studies on Sprague-Dawley male rats.

RESULTS: Peak concentration (Cmax), mean retention time from 0 to ∞ (MRT0→∞), and area under the curve (AUC0→10), (AUC0→∞) were 1.51, 1.14, 2.34, and 3.86 times higher in the co-administration group than in the individual administration group, respectively (P < 0.05). In addition, half-life (T1/2) was significantly prolonged in the co-administration group (P < 0.05). Meanwhile, the clearance and elimination rate constant (Ke) in the co-administration group were significantly lower than those in the individual administration group, just 50% of those in the individual administration group (P < 0.05). After co-administration of the drug, the pulegone content in all tissues of the rats was elevated to varying degrees, especially a significant increase in the drug content in lung tissues (P < 0.05).

CONCLUSION: After co-administration, the retention of pulegone in the body was prolonged, the elimination of pulegone from the body was delayed, and the accumulation of pulegone in the lungs was facilitated. Therefore, using RP as a Yin-Jing drug concoction has a significant cumulative effect of inducing upward mobilization and targeting lung tissues.

Key words： pharmacokinetics; Yin-Jing; pulegone; individual administration; combined administration

Cite this article

Yuanmei ZHANG , Heqing LIU , Shaowen WANG , Lele WANG , Yawen GAO , Rui SUN , Jihui TANG . Effect of Jiegeng (Radix Platycodi) on Jingjie (Herba Schizonepetae Tenuifoliae) “Yin-Jing” into the lungs based on pharmacokinetics[J]. Journal of Traditional Chinese Medicine, 2025 , 45(5) : 1040 -1047 . DOI: 10.19852/j.cnki.jtcm.2025.05.010

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