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Journal of Traditional Chinese Medicine >

2025 , Vol. 45 >Issue 3: 628 - 632

DOI: https://doi.org/10.19852/j.cnki.jtcm.2025.03.015

Effect of Neibu Huangqi Youhua formula (内补黄芪汤优化方) on postoperative wound healing, inflammatory factors and pain mediators of anal fistula

  • Yanyan XIONG ,
  • Renjin TANG ,
  • Xuelin LI ,
  • Hong LIU
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  • 1 Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
    2 West China School of Nursing, Sichuan University, Chengdu, China
    3 Department of Integrated Traditional Chinese and Western Medicine, Chengdu Shangjin Nanfu Hospital, Chengdu 611730, China
    4 Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu 610041, China

Received date: 2024-03-12

  Accepted date: 2024-08-30

  Online published: 2025-05-21

Supported by

Grant from the National Natural Science Foundation of China: CRL4DCAF4 E3 Ubiquitin Ligase Regulates the Pathogenesis of Colorectal Cancer(82172909)

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Abstract

OBJECTIVE: To explore the clinical efficacy of the Chinese medicine, Neibu Huangqi Youhua formula (内补黄芪汤优化方) combined with Kangfuxin solution (康复新液) for the nursing of patients after anal fistula surgery.
METHODS: A total of 160 cases with anal fistula who underwent surgical treatment were recruited, and divided into control group (treated with external application of Kangfuxin liquid gauze) and experimental group (receiving the Neibu Huangqi Youhua formula combined with Kangfuxin liquid gauze) based on a random numbering table. The wound recovery, postoperative pain and inflammation were evaluated and compared between the two groups.
RESULTS: At 3, 7, and 14 d after the operation, the wound healing rate of the experimental group was significantly higher than that of the control group at any time point. The visual analogue scale scores of the two groups gradually decreased in a time-dependent manner after surgery, while the experimental group showed a more significant downward trend in comparison with the control group. At 14 d after the operation, the experimental group had high levels of epidermal growth factor, fibroblast growth factor-1, secretory IgA, tissue inhibitor of matrix metalloproteinase-1, 5-hydroxytryptamine, prostaglandin E-2, substances P and neuropeptide Y compared with control group, but low levels of C-reactive protein, procalcitonin, and serum amyloid A protein.
CONCLUSIONS: The Neibu Huangqi Youhua formula can reduce the levels of inflammatory factors and pain mediators in patients after anal fistula surgery, thereby accelerating the process of wound healing and alleviating the pain of patients.

Key words： pain, postoperative; wound healing; rectal fistula; Neibu Huangqi Youhua formula

Cite this article

Yanyan XIONG , Renjin TANG , Xuelin LI , Hong LIU . Effect of Neibu Huangqi Youhua formula (内补黄芪汤优化方) on postoperative wound healing, inflammatory factors and pain mediators of anal fistula[J]. Journal of Traditional Chinese Medicine, 2025 , 45(3) : 628 -632 . DOI: 10.19852/j.cnki.jtcm.2025.03.015

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