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Journal of Traditional Chinese Medicine >

2025 , Vol. 45 >Issue 2: 225 - 233

DOI: https://doi.org/10.19852/j.cnki.jtcm.2025.02.008

Meta-Analyses

Efficacy of Jianpi formulas (健脾剂) in reducing the recurrence of colorectal adenoma after polypectomy: a systematic review and Meta-analysis

  • Jing XIAO ,
  • Danlei SONG ,
  • Caiming LIANG ,
  • Yinuo HE ,
  • Weifang ZHENG ,
  • Xiaqiu WU
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  • 1 Department of Biobank, Lanxi Hospital of Traditional Chinese Medicine, Jinhua 321102, China; Department of Anorectal, Lanxi Hospital of Traditional Chinese Medicine, Jinhua 321102, China
    2 School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China

Received date: 2024-02-11

  Accepted date: 2024-05-10

  Online published: 2025-03-10

Supported by

Jinhua Traditional Chinese Medicine Science and Technology Research Project: Gut Microbiota Distribution Characteristics in Spleen-Deficiency Colorectal Adenoma Patients(2023KR04);Jinhua Traditional Chinese Medicine Science and Technology Major Research Project: Clinical Efficacy and Mechanism of Shugan Jianpi Tiaochang Pills in Preventing Postoperative Recurrence of Colorectal Adenomas based on Metabolomics Technology(2024ZD03)

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Abstract

OBJECTIVES: To systematically review the efficacy and safety of Jianpi formulas (健脾剂) in reducing the recurrence of colorectal adenoma (CRA) after poly-pectomy.

METHODS: Randomized controlled trials (RCTs) investigating Jianpi formulas for CRA post-polypectomy were systematically retrieved from eight electronic databases. The quality of the methodology was assessed using the Cochrane collaboration tool. The Grades of Recommendations Assessment Development and Evaluation (GRADE) approach was employed for evidence assessment. Statistical analyses were conducted using Statistics and Data Analysis (STATA) 17 (StataCorp (College Station, TX, USA) and Review Manager (RevMan) 5.4 (The Cochrane Collaboration (London, UK).

RESULTS: The Meta-analysis, encompassing 18 RCTs with 1838 patients, revealed that Jianpi formulas significantly outperformed postoperative routine treatment. It demonstrated a reduction in the half-year recurrence rate [relative risk (RR) = 0.41, 95% confidence interval (CI) = 0.33-0.49, Z = 9.08, P < 0.000 01], the one-year recurrence rate [RR = 0.58, 95% CI= 0.49-0.69, Z= 6.12, P < 0.000 01], and an enhancement in the clinical effective rate [RR = 1.27, 95% CI = 1.19-1.36, Z= 7.06, P < 0.000 01]. The half-year recurrence rate and the clinical effective rate were medium-quality evidence. The one-year recurrence rate was low-quality evidence. Additionally, Jianpi formulas appear to be safe and do not increase adverse reactions compared to postoperative routine treatment alone.

CONCLUSION: Jianpi formulas exhibit efficacy in reducing postoperative half-year and one-year recurrence rates while improving the clinical effective rate after polypectomy for CRA.

Key words： recurrence; colorectal adenoma; Meta-analysis; randomized controlled trial; Jianpi formulas

Cite this article

Jing XIAO , Danlei SONG , Caiming LIANG , Yinuo HE , Weifang ZHENG , Xiaqiu WU . Efficacy of Jianpi formulas (健脾剂) in reducing the recurrence of colorectal adenoma after polypectomy: a systematic review and Meta-analysis[J]. Journal of Traditional Chinese Medicine, 2025 , 45(2) : 225 -233 . DOI: 10.19852/j.cnki.jtcm.2025.02.008

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