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Journal of Traditional Chinese Medicine >

2025 , Vol. 45 >Issue 1: 123 - 131

DOI: https://doi.org/10.19852/j.cnki.jtcm.2025.01.011

Yunpiqiangshen gel (运脾强肾浸膏) improves quality of life in dialysis patients

  • Manshu YU ,
  • Chunchun JIANG ,
  • Min YAO ,
  • Jianwu HUA ,
  • Yan JIANG ,
  • Min HUANG ,
  • Jianjing LIU ,
  • Yan ZHOU ,
  • Yuan WANG ,
  • Meixiao SHENG
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  • 1 Renal Division, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
    2 Renal Division, Zhangjiagang Hospital of Chinese Medicine, Suzhou 215638, China
    3 Renal Division, Jiangsu Province Hospital of Integration of Chinese and Western Medicine, Nanjing 210028, China

Received date: 2023-11-26

  Accepted date: 2024-04-22

  Online published: 2025-01-10

Supported by

Jiangsu Science and Technology Development Project of Chinese Medicine: Yunpiqiangshen Improves Quality of Life in Dialysis Patients in Basis of Zou’s Theory of Kidney Disease(ZD201904);Jiangsu Province Hospital of Chinese Medicine Peak Talent Program: Study on Promotion of Rehabilitation of Dialysis Patients by Traditional Chinese Medicine(Y2021RC10);National Natural Science Foundation of China: Study of Astragalus on Peritoneum Function by Myostatin-mediated Protein Turnover of Skeletal Muscle Cells(82004295);Science and Technology Planning Project of Jiangsu Province: Mechanism Study of Astragalus on Peritoneal Fibrosis by Pyroptosis of Peritoneal Mesothelial Cell via Peritoneal Mesothelial Cell(BK20211393);Outstanding Young Doctor's Fund of Jiangsu Province Hospital of Chinese Medicine: Traditional Chinese Medicine Improves Quality of Life in Chronic Renal Disease(2023QB0133)

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Abstract

OBJECTIVE: To evaluate the efficacy and safety of Yunpiqiangshen gel (运脾强肾浸膏) which composed of eleven herbs on quality of life (QOL) improvement.

METHODS: We enrolled 180 patients lasted from January 2020 to December 2021. Seventy-eight patients received standards of care (control group) and 76 patients received Yunpiqiangshen gel [Traditional Chinese Medicine, (TCM) group] for 6 months in statistical analysis. The primary outcome assessed using Kidney Disease Quality of Life Short Form Questionnaire version 1.3 (KDQOL-SFTM 1.3), including Short Form Health Survey (SF-36) and Kidney Disease Targeted Areas (KDTA) scores. The second outcomes included the TCM syndrome score, Fatigue Assessment Instrument (FAI) score, Modified Quantitative Subjective Global Assessment (MQSGA) score, anthropometric indicators, and blood chemical testing. Adverse events, including decompensated gastrointestinal symptoms, were evaluated.

RESULTS: The results showed that the mean change of SF-36 (75 ± 13 vs 64 ± 16, F = 6.070, P = 0.015) and KDTA (76 ± 7 vs 70 ± 9, F = 4.118, P = 0.044) scores in the TCM group had an improvement (increase) from baseline, as compared with the control group. Yunpiqiangshen gel also resulted in a significant improvement in almost dimensions of QOL. At the end of follow-up, the imputed percentage of patients in the response rate of TCM syndrome was greater in the TCM group than in the control group (76.32% vs 20.51%, χ 2 = 48.02, P = 0.000). The fatigue, soreness of waist, anorexia, abdominal distension, loose stool, and constipation were alleviated after Yunpiqiangshen gel therapy. The FAI (98.58 ± 25.08 vs 131.21 ± 31.85, F = 8.745, P = 0.004) and MQSGA (10.13 ± 2.84 vs 12.83 ± 3.85, F = 11.396, P = 0.001) scores in the TCM group had an improvement (reduce) from baseline compared with the control group. A higher level of albumin of patients in the TCM group compared with the control group. Diarrhea, vomit, and loose stool were more common in the TCM group, but generally mild in severity.

CONCLUSION: Compared with the standards of care, added Yunpiqiangshen gel was a safe and effective therapy for improving QOL in dialysis patients.

Key words： kidney failure; chronic; dialysis; quality of life; renal rehabilitation; Yunpiqiangshen gel; supporting information

Cite this article

Manshu YU , Chunchun JIANG , Min YAO , Jianwu HUA , Yan JIANG , Min HUANG , Jianjing LIU , Yan ZHOU , Yuan WANG , Meixiao SHENG . Yunpiqiangshen gel (运脾强肾浸膏) improves quality of life in dialysis patients[J]. Journal of Traditional Chinese Medicine, 2025 , 45(1) : 123 -131 . DOI: 10.19852/j.cnki.jtcm.2025.01.011

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