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Journal of Traditional Chinese Medicine >

2024 , Vol. 44 >Issue 6: 1067 - 1081

DOI: https://doi.org/10.19852/j.cnki.jtcm.20240927.002

Meta-Analyses

Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type

  • Chang GAN ,
  • Qingwen TAO ,
  • Haoying YI ,
  • Yuting BIAN ,
  • Jianming WANG
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  • 1 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
    2 Department of Traditional Chinese Medicine Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China
    3 Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing 100029, China

Received date: 2023-09-10

  Accepted date: 2023-12-22

  Online published: 2024-09-27

Supported by

National Natural Science Foundation of China: Therapy which Invigorating Kidney and Strengthening Bone Regulates the Balance between Osteoblast and Osteoclast in Treating Rheumatoid Arthritis Bone Destruction: a Mechanism Study(82074223);National Natural Science Foundation of China: Therapy which Invigorating Kidney and Strengthening Bone Regulates the Balance between Osteoblast and Osteoclast in Treating Rheumatoid Arthritis Bone Destruction: a Mechanism Study(82274435);Fifth Batch of National Training Program for Clinical Excellence in Chinese Medicine(2022178)

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Abstract

OBJECTIVE: To compare the efficacy and safety of different Traditional Chinese Medicine (TCM)-based kidney-tonifying and bone-strengthening therapies for rheumatoid arthritis (RA).

METHODS: The current Bayesian network Meta-analysis compared different TCM-based kidney-tonifying and bone-strengthening therapies for RA. Eight electronic databases and two trial registration platforms were searched. RevMan 5.4 and Stata 16 software were employed.

RESULTS: A total of 42 studies involving 3779 cases were included. The results showed that the most effective intervention for improving efficacy was Wanbi decoction (顽痹汤); Bushen Quhan Zhiwang decoction (补肾祛寒治尪汤) was superior in reducing the incidence of adverse reactions; and Qiwei Tongbi oral liquid (七味通痹口服液) effectively reduced C-reactive protein and erythrocyte sedimentation rate levels.

CONCLUSION: Combining TCMs with conventional Western Medicine can improve the clinical efficacy of RA treatments, reduce inflammatory indexes, and result in a higher safety profile. However, this conclusion needs to be verified by more high-quality randomized controlled trials.

Key words： arthritis, rheumatoid; Medicine, Chinese Traditional; tonifying kidney and strengthening bones; network Meta-analysis

Cite this article

Chang GAN , Qingwen TAO , Haoying YI , Yuting BIAN , Jianming WANG . Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type[J]. Journal of Traditional Chinese Medicine, 2024 , 44(6) : 1067 -1081 . DOI: 10.19852/j.cnki.jtcm.20240927.002

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