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Journal of Traditional Chinese Medicine >

2024 , Vol. 44 >Issue 4: 688 - 693

DOI: https://doi.org/10.19852/j.cnki.jtcm.20240617.001

Original articles

Effect of Jiedu Huayu decoction (解毒化瘀汤) on oral mucosal Axin and β-catenin expression in oral submucosal fibrosis model rats

  • Xuan ZHU ,
  • An LOU ,
  • Keke ZHU ,
  • Mingyu RUAN
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  • 1 Department of Science and Technology, Hunan University of Chinese Medicine, Changsha 410208, China
    2 Department of prosthodontics, Hunan University of Chinese Medicine Affiliated Dental Hospital, Changsha 410005, China
    3 Department of Stomatology, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410021, China
    4 School of Medicine, Hunan University of Chinese Medicine, Changsha 410208, China

Received date: 2023-01-11

  Accepted date: 2023-07-22

  Online published: 2024-06-17

Supported by

Scientific Research Project of Hunan Provincial Education Department: to Investigate the Mechanism of Blood-activating Circulation Through the Regulation of Blood Stasis and Detoxification based on Wnt β-catenin Signaling Pathway(21B0398);Study on the Epithelial Mesenchymal Transformation of Human Umbilical Vein Endothelial Cells Induced by Fuxin Formula(22C0190);Changsha City 2020 Annual Guiding Science and Technology Plan Projects: Effect of Blood Circulation and Detoxification Method on Epithelial Barrier Composition and Function of Oral Mucosa(kzd2001010)

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Abstract

OBJECTIVE: To investigate the protective effect of the Chinese herbal formula of Jiedu Huayu decoction (解毒化瘀汤, JHD) on oral mucosa of rats with oral submucosal fibrosis (OSF) and its potential mechanism of action.

METHODS: Sprague-Dawley male OSF model rats were constructed by injection of betaine and topical rubbing and were randomly grouped and administered by gavage for 4 weeks. Mouth opening and buccal mucosa scores interleukin levels and the expression of Axin and β-catenin proteins or genes were measured before and after drug administration.

RESULTS: After treatment with JHD the buccal mucosal lesions of rats were significantly reduced Axin protein and mRNA expression were significantly increased β-catenin protein and mRNA expression were significantly decreased interleukin-1β and interleukin-6 levels were decreased and interleukin-10 levels were increased.

CONCLUSION: The mechanism of action of JHD can effectively alleviate the pathological damage of buccal mucosa in OSF rats which may be related to the promotion of Axin expression and inhibition of β-catenin expression.

Key words： Axin protein; beta catenin; oral submucosal fibrosis; oral mucosa; Jiedu Huayu decoction

Cite this article

Xuan ZHU , An LOU , Keke ZHU , Mingyu RUAN . Effect of Jiedu Huayu decoction (解毒化瘀汤) on oral mucosal Axin and β-catenin expression in oral submucosal fibrosis model rats[J]. Journal of Traditional Chinese Medicine, 2024 , 44(4) : 688 -693 . DOI: 10.19852/j.cnki.jtcm.20240617.001

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