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A comprehensive review on pharmacognosy, phytochemistry and pharmacological activities of 8 potent Prunus species of southeast Asia
Received date: 2022-11-25
Accepted date: 2023-05-22
Online published: 2024-04-30
Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian sub-continent due to their broad nutritional and economic importance. Some most common species of genus Prunus are Prunus amygdalus, Prunus persica, Prunus armeniaca, Prunus avium, Prunus cerasus, Prunus cerasoides, Prunus domestica, Prunus mahaleb, etc. A newly introduced species of Prunus i.e Prunus sunhangii is recently discovered which is morphologically very similar to Prunus cerasoides. Plants of Prunus species are short to medium-sized deciduous trees mainly found in the northern hemisphere. In India and its subcontinent, it extends from the Himalayas to Sikkim, Meghalaya, Bhutan, Myanmar etc. Different Prunus species have been extensively studied for their morphological, microscopic, pharmacological and phytoconstituents characteristics. Total phenolic content of Prunus species explains the presence of phenols in high quantity and pharmacological activity due to phenols. Phytochemical screening of species of genus Prunus shows the presence of wide phytoconstituents which contributes in their pharmacological significance and reveals the therapeutic potential and traditional medicinal significance of this genus. Genus Prunus showed a potent antioxidant activity analyzed by 1,1-diphenyl-2-picryl-hydrazyl radical assay. Plant species belonging to the genus Prunus is widely used traditionally for the treatment of various disorders. Some specific Prunus species possess potent anticancer, anti-inflammatory, hypoglycemic etc. activity which makes the genus more interesting for further research and findings. This review is an attempt to summarize the comprehensive study of Prunus
Key words: Rosaceae; Prunus; antineoplastic agents; hypoglycemic agents; distribution; phytochemistry; review
Agrawal Shikha , Kumar Adarsh , Kumar Singh Ankit , Singh Harshwardhan , Thareja Suresh , Kumar Pradeep . A comprehensive review on pharmacognosy, phytochemistry and pharmacological activities of 8 potent Prunus species of southeast Asia[J]. Journal of Traditional Chinese Medicine, 2024 , 44(3) : 620 -628 . DOI: 10.19852/j.cnki.jtcm.2024.03.002
| 1. | Hummer KE, Janick J. Rosaceae: taxonomy, economic importance, genomics, in Genetics and genomics of Rosaceae Springer 2009; 6: 1-17. |
| 2. | Rasheed HM, Khan T, Wahid F, et al. Chemical composition and vasorelaxant and antispasmodic effects of essential oil from Rosa indica L. petals. Evid Based Complementary Altern Med 2015; 2015: 1-9. |
| 3. | Kant R, Shukla RK, Shukla A. A review on peach (Prunus persica): an asset of medicinal phytochemicals. Int J Res Appl Sci Eng Technol 2018; 6: 2186-200. |
| 4. | Lee S, Wen J. A phylogenetic analysis of Prunus and the Amygdaloideae (Rosaceae) using ITS sequences of nuclear ribosomal DNA. Am J Bot 2001; 88: 150-60. |
| 5. | Poonam V, Kumar G, Reddy LC, et al. Chemical constituents of the genus Prunus and their medicinal properties. Curr Med Chem 2011; 18: 3758-824. |
| 6. | Bhatnagar S, Sastri B. The wealth of India raw materials (a dictionary of indian raw materials and industrial products). New Delhi, India 1960; 10: 64-8. |
| 7. | Zhang X, Jiang Z, Yusupov Z, et al. Prunus sunhangii: a new species of Prunus from central China. Plant diversity 2019; 4: 19-25. |
| 8. | Leather SR. Prunus padus L. J Ecol 1996; 84: 125-32. |
| 9. | Hodel RG, Zimmer E, Wen J. A phylogenomic approach resolves the backbone of Prunus (Rosaceae) and identifies signals of hybridization and allopolyploidy. Mol Phylogenet Evol 2021; 160: 107-18. |
| 10. | Shi S, Li J, Sun J, et al. Phylogeny and classification of Prunus sensu lato (R osaceae). J Integr Plant Biol 2013; 55: 1069-79. |
| 11. | B Hanbali L, J Haddad J. The antioxidant properties of red sour cherry (Prunus cerasus L.) extracts: laboratory assessment of antioxidant activity and antioxidant compounds under temperature variations. Curr Nutr Food Sci 2015; 11: 31-43. |
| 12. | Sabatini L, Fraternale D, Giacomo B, et al. Chemical composition, antioxidant, antimicrobial and anti-inflammatory activity of Prunus spinosa L. fruit ethanol extract. J Funct Foods 2020; 67: 1-10. |
| 13. | Lim T. Prunus salicina, in edible medicinal and non-medicinal plants. Springer 2012; 4: 509-14. |
| 14. | Joshi SR. Himalayan cherry Prunus cerasoides. Bee World 2004; 85: 73-3. |
| 15. | Arora DS, Mahajan HJ. biotechnology. Major Phytoconstituents of Prunus cerasoides responsible for antimicrobial and antibiofilm potential against some reference strains of pathogenic bacteria and clinical isolates of MRSA. Appl Biochem Biotechnol 2019; 188: 1185-204. |
| 16. | Fang J, Zhou Q, Liu Z, et al. Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression. J Carcinog 2007; 28: 858-64. |
| 17. | Liu W, Nan G, Nisar MF, et al. Chemical constituents and health benefits of four Chinese plum species. J Food Qual 2020; 2020: 1-17. |
| 18. | Zhou Q, Yan B, Hu X, et al. Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin. Mol Cancer Ther 2009; 8: 1684-91. |
| 19. | Fu B, Xue J, Li Z, et al. Chrysin inhibits expression of hypoxia-inducible factor-1α through reducing hypoxia-inducible factor-1α stability and inhibiting its protein synthesis. Mol Cancer Ther 2007; 6: 220-6. |
| 20. | Kim SK, Kim HJ, Choi SE, et al. Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E 2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg. Arch Pharm Res 2008; 31: 424-8. |
| 21. | Das B, Ahmed N, Singh P. Prunus diversity-early and present development: a review. Int J Biodivers Conserv 2011; 3: 721-34. |
| 22. | Kester DE, Gradziel TM, Grasselly C, et al. Almonds (Prunus). Genetic resources of temperate fruit and nut crops. Acta Hortic 1991; 290: 701-60. |
| 23. | Scorza R, Okie WR. Peaches (Prunus). Genetic resources of temperate fruit and nut crops. Acta Hortic 1991; 290: 177-234. |
| 24. | Mehlenbacher SA, Cociu V, Hough F. Apricots (Prunus). Genetic resources of temperate fruit and nut crops. Acta Hortic 1991; 290, 65-110. |
| 25. | Blando F, Gerardi C, Nicoletti I. Sour cherry (Prunus cerasus L) anthocyanins as ingredients for functional foods. J Biomed Biotechnol 2004; 2004: 253-8. |
| 26. | Tiwari C, Chubey S, Kurele R, et al. A Review on padmaka (prunus cerasoides d. don): different species and their medicinal uses. Ayushdhara 2016; 4: 1051-5. |
| 27. | Dhingra N, Sharma R, Kar A. Antioxidative and antiproliferative activities of isolated compounds from Prunus domestica: an in vitro study. Int J Phytomedicine 2013; 5: 341-6. |
| 28. | Al-Said MS, Hifnawy MS. Dihydrocoumarin and certain other coumarins from Prunus mahaleb seeds. J Nat Prod 1986; 49: 721. |
| 29. | Joseph N, Anjum N, Tripathi Y. Prunus cerasoides D. Don: a review on its ethnomedicinal uses, phytochemistry and pharmacology. Int J Pharm Sci 2018; 48: 62-9. |
| 30. | Kester DE, Gradziel TM. Grasselly C. Almonds (Prunus). Genetic resources of temperate fruit and nut crops. Acta Hortic 1991; 290: 701-58. |
| 31. | Rana T, Chandel V, Hallan V. Himalayan wild cherry (Prunus cerasoides D. Don): a new host of Apple chlorotic leaf spot virus. For Pathol 2008; 38: 73-7. |
| 32. | Strasburger E, Noll F, Schenck H, Schimper AF. Text book of botany for univertities. 33 ed. Jena: Gustav Fischer Verlag, 1991: 778-80. |
| 33. | Ruiz D, Egea J. Phenotypic diversity and relationships of fruit quality traits in apricot (Prunus armeniaca L.) germplasm. Euphytica 2008; 163: 143-58. |
| 34. | Fathi M, Mohebbi M, Koocheki A. Introducing prunus cerasus gum exudates: chemical structure, molecular weight, and rheological properties. Food Hydrocoll 2016; 61: 946-55. |
| 35. | Beyer M, Hahn R, Peschel S, et al. Analysing fruit shape in sweet cherry (Prunus avium L.). Sci Hortic 2002; 96: 139-50. |
| 36. | Jangwan J, Kumar N. Isolation and Characterization of new flavonoid glycoside from the seeds of Prunus cerasoides. J Med Pl Stud 2015; 3: 20-2. |
| 37. | Kayano S, Kikuzaki H, Fukutsuka N, et al. Antioxidant activity of prune (Prunus domestica L.) constituents and a new synergist. J Agric Food Chem 2002; 50: 3708-12. |
| 38. | Guitian J. Why Prunus mahaleb (Rosaceae) produces more flowers than fruits. Am J Bot 1993; 80: 1305-9. |
| 39. | Potter D. Prunus. In: Kole C. Wild crop relatives: genomic and breeding resources. Heidelberg: Springer, 2011: 129-45. |
| 40. | Joseph N, Anjum N, Tripathi Y. Phytochemical screening and evaluation of polyphenols, flavonoids and antioxidant activity of Prunus cerasoides D. Don leaves. J Pharm Res 2016; 10: 502-8. |
| 41. | Vogt T. Phenylpropanoid biosynthesis. Molecular plant 2010; 3: 2-20. |
| 42. | Iwashina T. The structure and distribution of the flavonoids in plants. J Plant Res 2000; 113: 287. |
| 43. | Panche A, Diwan A, Chandra S. Flavonoids: an overview. J Nutr Sci 2016; 5: 1-15. |
| 44. | Geibel M, Geiger H, Treutter D. Tectochrysin 5-and genistein 5-glucosides from the bark of Prunus cerasus. Phytochemistry 1990; 29: 1351-3. |
| 45. | Nagarajan GR, Parmar VS. Three new flavonoids in Prunus cerasus. Phytochemistry 1977; 16: 1317-8. |
| 46. | Jung HA, Kim AR, Chung HY, Choi JS. In vitro antioxidant activity of some selected Prunus species in Korea. Arch Pharm Res 2002; 25: 865-72. |
| 47. | Ohtsuki K, Abe A, Mitsuzumi H, et al. Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats. J Nutri Sci Vitam 2002; 48: 420-22. |
| 48. | Bugianesi R, Catasta G, Spigno P, et al. Naringenin from cooked tomato paste is bioavailable in men. J Nutri 2002; 132: 3349-52. |
| 49. | Nakamura S, Fujimoto K, Matsumoto T, et al. Structures of acylated sucroses and an acylated flavonol glycoside and inhibitory effects of constituents on aldose reductase from the flower buds of Prunus mume. J Nat Med 2013; 67: 799-806. |
| 50. | Veli?kovi? JM, Kosti? DA, Stojanovi? GS, et al. Phenolic composition, antioxidant and antimicrobial activity of the extracts from Prunus spinosa L. Fruit Hem Ind 2014; 68: 297-303. |
| 51. | Chen K, Ohmura W, Doi S, Aoyama M. Termite feeding deterrent from Japanese larch wood. Bioresour Technol 2004; 95: 129-34. |
| 52. | Mertens S, Talcott S, Percival S. Low Concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr 2003; 133: 2669-74. |
| 53. | Reed J. Cranberry flavonoids, atherosclerosis and cardiovascular health. Crit Rev Food Sci Nutr 2002; 42: 301-16. |
| 54. | Haraguchi H, Mochida Y, Sakai S, et al. Protection against oxidative damage by dihydroflavonols in Engelhardtia chrysolepis. Biosci Biotechnol Biochem 1996; 60: 945-8. |
| 55. | Wei H, Bowen R, Cai Q, Barnes S, Wang Y. Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proceedings of the Society for Experimental Biology and Medicine 1995; 208: 124-30. |
| 56. | Tham DM, Gardner CD, Haskell WL. Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab 1998; 83: 2223-35. |
| 57. | Bagchi D, Bagchi M, Stohs SJ, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 2000; 148: 187-97. |
| 58. | Howell AB. Cranberry proanthocyanidins and the maintenance of urinary tract health. Crit Rev Food Sci Nutr 2002; 42: 273-8. |
| 59. | Wang H, Nair MG, Strasburg GM, Booren AM, Gray JI. Antioxidant polyphenols from tart cherries (Prunus cerasus). J Agric Food Chem 1999; 47: 840-4. |
| 60. | Wang H, Nair MG, Iezzoni AF, et al. Quantification and characterization of anthocyanins in Balaton tart cherries. J Agric Food Chem 1997; 45: 2556-60. |
| 61. | Lahlou H, Hirai N, Tsuda M, Ohigashi H. Triterpene phytoalexins from nectarine fruits. Phytochemistry 1999; 52: 623-9. |
| 62. | Amico V, Barresi V, Condorelli D, Spatafora C, Tringali C. Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure activity relationships. J Agric Food Chem 2006; 54: 810-4. |
| 63. | Sang S, Li G, Tian S, et al. An unusual diterpene glycoside from the nuts of almond (Prunus amygdalus Batsch). Tetrahedron lett 2003; 44: 1199-202. |
| 64. | Sang S, Cheng X, Fu H, et al. New type sesquiterpene lactone from almond hulls (Prunus amygdalus Batsch). Tetrahedron Lett 2002; 43: 2547-49. |
| 65. | Singh G, Singh S, Bani S. Oleanolic acid. Drugs Future 1994; 19: 450-1. |
| 66. | Kashiwada Y, Wang H, Nagao T, et al. Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. J Nat Prod 1998; 61: 1090-5. |
| 67. | Kayano S, Kikuzaki H, Hashimoto S, et al. Structural elucidation of new glucosyl terpenates isolated from prunes (Prunus domestica L.). Koryo, Terupen oyobi Seiyu Kagaku ni kansuru Toronkai Koen Yoshishu 2004; 48: 297. |
| 68. | Kim DO, Chun OK, Kim YJ, Moon HY, Lee CY. Quantification of polyphenolics and their antioxidant capacity in fresh plums. J Agric Food Chem 2003; 51: 6509-15. |
| 69. | Garofuli? IE, Jambrak AR, Milo?evi? S, et al. The effect of gas phase plasma treatment on the anthocyanin and phenolic acid content of sour cherry Marasca (Prunus cerasus var. Marasca) juice. LWT-Food Sci Technol 2015; 62: 894-900. |
| 70. | Ieri F, Pinelli P, Romani A. Simultaneous determination of anthocyanins, coumarins and phenolic acids in fruits, kernels and liqueur of Prunus mahaleb L. Food chem 2012; 135: 2157-62. |
| 71. | Ruiz D, Egea J, Tomás F, Gil MI. Carotenoids from new apricot (Prunus armeniaca L.) varieties and their relationship with flesh and skin color. J Agric Food Chem 2005; 53: 6368-74. |
| 72. | Zaghdoudi K, Pontvianne S, Framboisier X, et al. Accelerated solvent extraction of carotenoids from: Tunisian Kaki (Diospyros kaki L.), peach (Prunus persica L.) and apricot (Prunus armeniaca L.). Food Chem 2015; 184: 131-9. |
| 73. | Vetter J. Plant cyanogenic glycosides. Toxicon 2000; 38: 11-36. |
| 74. | Kim GJ, Choi HG, Kim JH, et al. Anti-allergic inflammatory effects of cyanogenic and phenolic glycosides from the seed of Prunus persica. Nat Prod Commun 2013; 8: 1739-40. |
| 75. | Amico V, Barresi V, Condorelli D, Spatafora C, Tringali C. Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure activity relationships. J Agric Food Chem 2006; 54: 810-4. |
| 76. | Tungmunnithum D, Abid M, Elamrani A, Drouet S, Addi M, Hano C. Almond skin extracts and chlorogenic acid delay chronological aging and enhanced oxidative stress response in yeast. Life 2020; 10: 80-9. |
| 77. | Murathan ZT, Kaya A, Erbil N, et al. Comparison of bioactive components, antimicrobial and antimutagenic features of organically and conventionally grown almond hulls. Erwerbs-Obstbau 2020; 62: 463-72. |
| 78. | Musarra M, Ginestra G, Smeriglio A, et al. The antimicrobial and antiviral activity of polyphenols from almond (Prunus dulcis L.) skin. Nutrients 2019; 11: 2355-62. |
| 79. | Jesus F, Goncalves A, Alves G, Silva L. Health benefits of Prunus avium plant parts: An unexplored source rich in phenolic compounds. Food Rev Int 2020; 38: 1-29. |
| 80. | Nakagawa T, Allam AE, Ohnuki K, Shimizu K. Biological activities of extracts from different parts of two cultivars of Prunus persica ‘Akatsuki'and ‘Fastigiata’. Nat Prod Commun 2018; 13. doi:10.1177/1934578X1801301015. |
| 81. | Oliveira A, Pintado M, Almeida DP. Phytochemical composition and antioxidant activity of peach as affected by pasteurization and storage duration. LWT-Food Sci Technol 2012; 49: 202-7. |
| 82. | Patel K, Singh GK, Patel DK. A review on pharmacological and analytical aspects of naringenin. Chin J Integr Med 2018; 24: 551-60. |
| 83. | Won Y, Kim J, Lizardo R, et al. The flavonol isoquercitrin promotes mitochondrial-dependent apoptosis in SK-Mel-2 melanoma cell via the PI3K/AKT/mTOR pathway. Nutrients 2020; 12: 3683-90. |
| 84. | Bell PG, Gaze DC, Davison GW, et al. Montmorency tart cherry (Prunus cerasus L.) concentrate lowers uric acid, independent of plasma cyanidin-3-O-glucosiderutinoside. J Funct Foods 2014; 11: 82-90. |
| 85. | Beszterda M, Frański R. Detection of flavone C-glycosides in the extracts from the bark of Prunus avium L. and Prunus cerasus L. Eur J Mass Spectrom 2020; 26: 369-75. |
| 86. | Stompor M. A review on sources and pharmacological aspects of sakuranetin. Nutrients 2020; 12: 513. |
| 87. | McNulty J, Nair J, Bollareddy E, et al. Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations. Phytochemistry 2009; 70: 2040-6. |
| 88. | Singh J, Jayaprakasha G, Patil BS. Extraction, identification, and potential health benefits of spinach flavonoids: a review. Advances in plant phenolics: from chemistry to human health. ACS Symposium Series 2018; 1286: 107-36. |
| 89. | Jena AK, Vasisht K, Karan M. Therapeutic management of benign prostatic hyperplasia: from synthetics to naturals. Annu Res Rev Biol 2017; 17: 1-34. |
| 90. | K?ksal ?, Nalbantsoy A, Karabay N. Prunetin inhibits nitric oxide activity and induces apoptosis in urinary bladder cancer cells via CASP3 and TNF-α genes. Mol Biol Rep 2021; 48: 7251-9. |
| 91. | Khwaza V, Oyedeji OO, Aderibigbe BA. Ursolic acid-based derivatives as potential anti-cancer agents: An update. Int J Mol Sci 2020; 21: 5920-30. |
| 92. | Lombardi G, Lucarini M, Lanzi S, Aguzzi A, Cappelloni M. Nutrients and antioxidant molecules in yellow plums (Prunus domestica L.) from conventional and organic productions: a comparative study. J Agric Food Chem 2004; 52: 90-4. |
| 93. | Kim M, Choi SY, Lee P, Hur J. Neochlorogenic acid inhibits lipopolysaccharide-induced activation and pro-inflammatory res-ponses in BV2 microglial cells. Neurochem Res 2015; 40: 1792-8. |
| 94. | Samanta SK, Bhattacharya K, Mandal C, Pal BC. Identification and quantification of the active component quercetin 3-O-rutinoside from Barringtonia racemosa, targets mitochondrial apoptotic pathway in acute lymphoblastic leukemia. J Asian Nat Prod Res 2010; 12: 639-48. |
| 95. | Panda S, Kar A. Apigenin (4 ‘, 5, 7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. J Pharm Pharmacol 2007; 59: 1543-8. |
| 96. | Zhao JG, Yan QQ, Xue RY, Zhang J, Zhang YQ. Isolation and identification of colourless caffeoyl compounds in purple sweet potato by HPLC-DAD-ESI/MS and their antioxidant activities. Food chem 2014; 161: 22-6. |
| 97. | Bouayed J, Rammal H, Dicko A, Younos C, Soulimani R. Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects. J Neurol Sci 2007; 26: 77-84. |
| 98. | Kakkar S, Bais S. A review on protocatechuic acid and its pharmacological potential. Int Sch Res Notices 2014; 943-52. |
| 99. | Santamour Jr FS, Riedel LG. Distribution and inheritance of scopolin and herniarin in some Prunus species. Biochem Syst Ecol 1994; 22: 197-201. |
| 100. | Newary S, Afifi S, Aly M, et al. Chemical profile of Launaea nudicaulis ethanolic extract and its antidiabetic effect in streptozotocin-induced rats. Molecules 2021; 26: 1000. |
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