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Journal of Traditional Chinese Medicine >

2024 , Vol. 44 >Issue 3: 586 - 594

DOI: https://doi.org/10.19852/j.cnki.jtcm.2024.03.003

Original articles

Effect of pediatric Tuina on children's recurrent acute respiratory tract infections: a retrospective cohort study in Southern China

  • Lingjia YIN ,
  • LUNDBORG Cecilia ST?LSBY ,
  • Darong WU ,
  • Jinghua YANG ,
  • Helle M?lsted ALVESSON ,
  • Jianxiong CAI ,
  • Taoying LU ,
  • Qianwen XIE ,
  • Gaetano MARRONE
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  • 1 Department of Global Public Health, Karolinska Institutet, Stockholm 17177, Sweden; State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Outcome Assessment Research Team in Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Health Construction Administration Centre, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China
    2 Department of Global Public Health, Karolinska Institutet, Stockholm 17177, Sweden
    3 State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Outcome Assessment Research Team in Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Health Construction Administration Centre, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China
    4 Department of Pediatrics, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China
    5 Outcome Assessment Research Team in Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China

Received date: 2023-01-22

  Accepted date: 2023-05-25

  Online published: 2024-04-30

Supported by

National Key R & D Program of China: Intelligent Construction and Application Demonstration of Evidence-Based Systems for Key Diseases in Traditional Chinese Medicine(2019YFC1709800);Construction of Clinical and Basic Databases for 10 Key Diseases in Traditional Chinese Medicine(2019YFC1709802);Science and Technology Planning Project of Guangdong Province: the Opening and Operation of the Key Laboratory for Clinical Research on Traditional Chinese Medicine Syndromes in Guangdong Province(2017B030314166);Key-Area Research and Development Program of Guangdong Province: Systematic Research Project on Diagnostic Criteria for Diseases Related to Lingnan Dampness Syndrome(2020B1111100010)

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Abstract

OBJECTIVE: To determine the effectiveness of pediatric Tuina (PT) in preventing recurrent acute respiratory tract infections (ARTIs) in children.

METHODS: This is a retrospective cohort study based on the electronic medical records of children with recurrent ARTIs in 2016. Children were divided into a PT group or a non-PT group, according to whether they had received PT or not in 2016. The primary outcome was the number of ARTI episodes in 2017 and 2018. The secondary outcomes were the number of ARTIs leading to outpatient department visits and outpatient antibiotic prescriptions due to ARTIs in the same time period. Negative binomial regressions were used to detect the association between PT and the outcomes.

RESULTS: A total of 2303 children were included in the analysis, including 94 in the PT group and 2209 in the non-PT group. Children who received PT six or more times in 2016 had fewer episodes of ARTIs in 2017 [incidence rate ratio (IRR): 0.59, 95% confidence interval (CI) (0.42-0.84)] and 2018 [IRR: 0.58, 95% CI (0.36-0.94)] and fewer outpatient department visits due to ARTIs in 2017 [IRR: 0.56, 95% CI (0.38-0.83)] than children who had not received PT in 2016. There was no significant difference in the number of outpatient antibiotic prescriptions between the two groups.

CONCLUSIONS: Receiving PT six or more times within one year is associated with a decrease in recurrent ARTIs in children in the following two years. Randomized controlled trials are needed for effect evaluation prior to establishing PT as a method for preventing recurrent ARTIs among children.

Key words： child; massage; pediatric Tuina; respiratory tract infections

Cite this article

Lingjia YIN , LUNDBORG Cecilia ST?LSBY , Darong WU , Jinghua YANG , Helle M?lsted ALVESSON , Jianxiong CAI , Taoying LU , Qianwen XIE , Gaetano MARRONE . Effect of pediatric Tuina on children's recurrent acute respiratory tract infections: a retrospective cohort study in Southern China[J]. Journal of Traditional Chinese Medicine, 2024 , 44(3) : 586 -594 . DOI: 10.19852/j.cnki.jtcm.2024.03.003

References

1. Naghavi M, Abajobir AA, Abbafati C, et al. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017; 390: 1151-210.
2. McAllister DA, Liu L, Shi T, et al. Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis. Lancet Glob Health 2019; 7: e47-57.
3. Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet 2016; 388: 3027-35.
4. Nicolai A, Frassanito A, Nenna R, et al. Risk factors for virus-induced acute respiratory tract infections in children younger than 3 years and recurrent wheezing at 36 months follow-up after discharge. Pediatr Infect Dis J 2017; 36: 179-83.
5. Yin XM, Tian GX, Wang TY, et al. Correlation analysis between weather data obtained by python crawler and consultation rate of lung diseases in children. Zhong Guo Xun Zheng Xin Xue Guan Yi Xue Za Zhi 2019; 11: 1047-49, 61.
6. Li ZL, Wu P, Li SQ, Ma J, Ye K. Analysis of influencing factors of 2-5 years old children with recurrent upper respiratory tract infection. Zhong Guo Yi Yao Dao Bao 2019; 16: 88-91.
7. Toivonen L, Karppinen S, Schuez-Havupalo L, et al. Burden of recurrent respiratory tract infections in children: a prospective cohort study. Pediatr Infect Dis J 2016; 35: e362-9.
8. de Martino M, Ballotti S. The child with recurrent respiratory infections: normal or not? Pediatr Allergy Immunol 2007; Suppl 18: 13-8.
9. Cohen R, Just J, Koskas M, et al. Recurrent respiratory tract infections: how should we investigate and treat? Arch Pediatr 2005; 12: 183-90.
10. El-Azami-El-Idrissi M, Lakhdar-Idrissi M, Chaouki S, Atmani S, Bouharrou A, Hida M. Pediatric recurrent respiratory tract infections: when and how to explore the immune system? (About 53 cases). Pan Afr Med J 2016; 24: 53.
11. Munteanu AN, Surcel M, Huica RI, et al. Peripheral immune cell markers in children with recurrent respiratory infections in the absence of primary immunodeficiency. Exp Ther Med 2019; 18: 1693-700.
12. Schaad UB, Esposito S, Razi CH. Diagnosis and management of recurrent respiratory tract infections in children: a practical guide. Arch Pediatr Infect Dis 2015; 4: e31039.
13. Chicoulaa B, Haas H, Viala J, Salvetat M, Olives JP. How French general practitioners manage and prevent recurrent respiratory tract infections in children: the SOURIRRE survey. Int J Gen Med 2017; 10: 61-8.
14. Marengo R, Ortega Martell JA, Esposito S. Paediatric recurrent ear, nose and throat infections and complications: can we do more? Infect Dis Ther 2020; 9: 275-90.
15. Wang DQ, Lin XF. Discussion on massage therapy to health protection in prescriptions worth a thousand gold. Shandong Zhong Yi Za Zhi 2000; 19: 579-80.
16. Huillet A, Erdie-Lalena C, Norvell D, Davis BE. Complementary and alternative medicine used by children in military pediatric clinics. J Altern Complement Med 2011; 17: 531-7.
17. Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report 2008: 1-23.
18. Smith C, Eckert K. Prevalence of complementary and alternative medicine and use among children in South Australia. J Paediatr Child Health 2006; 42: 538-43.
19. Li H, Wu JW, Zhou YP. Latest research progress of Traditional Chinese Medicine anti-respiratory virus. Zhong Guo Lin Chuang Yao Li Xue Za Zhi 2020; 36: 2725-7, 31.
20. Tang W, Zhang LY, Tang LP, Liu YH, Shao XN. Effects of massage in treatment of recurrent respiratory tract infection: a Meta-analysis. Zhong Hua Zhong Yi Yao Za Zhi 2016; 31: 4277-80.
21. Li RR, Wang YG, Ren FJ, Zhao Y, Xiao X. Meta-analysis on Tuina treatment for children with acute upper respiratory infection. Liaoning Zhong Yi Za Zhi 2018; 45: 1801-4.
22. Weng ZL, Wen XY, Yang JH. Effect analysis of clinical pathway of integrated Chinese and Western Medicine therapy for bronchitis in children. Xin Zhong Yi 2017; 49: 104-6.
23. National Health Commision, National Administration of Traditional Chinese Medicine. Chinese medicine health management service for children aged 0-36 months, 2013-8-2, cited 2020-7-16. Available from URL: http://www.natcm.gov.cn/yizhengsi/gongzuodongtai/2018-03-24/2783.html.
24. Liu F, Li M, Zhang F, Cao ML. Expert consensus on intervention in recurrent respiratory tract infection in children with Tuina guided by ‘treatment before its onset’ in TCM. Shi Jie Zhong Xi Yi Jie He Za Zhi 2020; 15: 767-9, 84.
25. Wang YG, Sun WQ, Zhan Q, Committee HQCCHEGoCITSCaC. Expert consensus on children Tuina intervention with coronavirus disease 2019 in children (first edition). Tianjin Zhong Yi Yao 2020; 37: 1114-8.
26. Population Division of the Guangzhou Municipal Bureau of Statistics, Population size and distribution of Guangzhou in 2016, 2017-3-1, cited 2020-10-31. Available from URL: http://tjj.gz.gov.cn/stats_newtjyw/tjsj/tjgb/qtgb/content/post_8540209.html.
27. Zang WB, Liu GE, Xu F, Xiong XJ. The effect of urban resident basic medical insurance on household consumption. Jing Ji Yan Jiu 2012; 47: 75-85.
28. Hong JM, Zhao SY, Mo ZY, Qiu YB, Guo YQ. A report on the storage of the extend codes standard dictionary of international classification of diseases for the hospitals in Guangdong province. Zhong Guo Bing An 2007; 8: 4-5.
29. Association TprgoCM. Clinical definition and treatment principles of recurrent respiratory tract infections. Zhong Hua Er Ke Za Zhi 2008; 46: 108-10.
30. de Oliveira TB, Klering EA, da Veiga ABG. Is recurrent respiratory infection associated with allergic respiratory disease? J Asthma 2019; 56: 160-6.
31. Yang Y. Clinical study of pediatric Tuina on recurrent respiratory tract infection. Guangzhou: Guangzhou University of Chinese Medicine; 2015: 1-32
32. Selda Yuzer Alsac SP. Effects of acupressure and massage therapy in relieving respiratory problems in children with respiratory distress. Int J Caring Sci 2019; 12: 1537.
33. Helen MM, Hepzibah B, Anita D. Effectiveness of massage therapy on respiratory status among toddlers with lower respiratory tract infection. J Health Ailled Sci NU 2015; 5: 49-54.
34. Liu ZJ, Li T, Zhao LJ. Analysis on the rules of acupoint application of massage prescription in children with recurrent respiratory tract infections. Zhong Yi Zhong Yao 2019; 32: 265.
35. Bossuyt X, Moens L, Van Hoeyveld E, et al. Coexistence of (partial) immune defects and risk of recurrent respiratory infections. Clin Chem 2007; 53: 124-30.
36. Pasternak G, Lewandowicz-Uszyńska A, Pento? K. Disorders of humoral immunity in children with IgG subclass deficiency and recurrent respiratory infections. Adv Exp Med Biol 2018; 1108: 99-106.
37. Feng XB, Huang W, Liu F, Fang CY, Yu SL, Ma YH. Recurrent respiratory tract infection and immunoglobulin G subclass deficiency in children. Binzhou Yi Xue Yuan Xue Bao 1996; 19: 119-21.
38. Liu S, Sun JX, Zhou ZX. Recurrent respiratory tract infection and deficiency of immunoglobulin G and IgA subclasses in children. Shi Yong Er Ke Lin Chuang Za Zhi 2002; 17: 328-9.
39. Li G, Chen Y, Chen XK. The effect of massage for children on the physical development and immune function of kindergarten children. Shenzhen Zhong Xi Yi Jie He Za Zhi 2017; 27: 70-1.
40. Zhuo Y, Zhang X, Liu MJ, et al. Effect of chiropractic therapy of Traditional Chinese Medicine on immune function of children with recurrent respiratory tract infection. Zhong Guo Fu You Bao Jian 2013; 28: 3782-33.
41. Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect 2006; 134: 1129-40.
42. Wayse V, Yousafzai A, Mogale K, Filteau S. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur J Clin Nutr 2004; 58: 563-7.
43. Karatekin G, Kaya A, Salihoglu O, Balci H, Nuhoglu A. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr 2009; 63: 473-7.
44. Wang XJ, Zhao XP, Wang CZ, Peng NC, Li SJ, Li HJ. The influence of Liu's pediatric massage therapy on serum 25-hydroxyvitamin D level in children with vitamin D deficiency. Zhong Yi Yao Dao Bao 2018; 24: 47-9.
45. Li L, Wang F, Liu Y, Gu F. Intestinal microbiota dysbiosis in children with recurrent respiratory tract infections. Microb Pathog 2019; 136: 103709.
46. Mao YL, Zhang H, Chen ZW. Study on the mechanism of infantile Tuina based on the theraputic effects of gut microbiota on respiratory and digestive diseases. Zhong Yi Yao Dao Bao 2017; 23: 40-2.
47. Wang LQ, Ge JL. Immunization and intestinal canal microecosystem mechanism of chiropractic in treating children's fever caused by exogenous pathogens. Henan Zhong Yi 2007; 27: 25-7.
48. Zhu Y, Xiong Y, Gu Y, Li Q, Liu Y. Chiropractic therapy modulated gut microbiota and attenuated allergic airway inflammation in an immature rat model. Med Sci Monit 2020; 26: e926039.
49. Wang ZH, Yang QY, Liu MJ, et al. Effect of back massage on serum immune cells and immunoglobulin in subacute aging and immunocompromised rabbits. Zhong Guo Zhong Yi Ji Chu Yi Xue Za Zhi 2020; 26: 622-4.
50. Shen YP, Meng QZ, Meng LZ, Liu J. The effect of Tuina as an adjuvant to children's recurrent respiratory tract infections and the influence on the serum immunoglobulin. Shandong Yi Yao 2015; 55: 82-4.
51. Chen WG. Effect of massage therapy on serum immunoglobulin level in children with recurrent respiratory tract infection. Guangming Zhong Yi 2017; 32: 2976-8.
52. Wang JL, Wang C, Xiong B, Liu JC. Effect of massage combined with chiropracticon on changes of T lymphocyte subsets and serum immunoglobulin levels for children with recurrent respiratory tract infection. Sichuan Zhong Yi 2019; 37: 186-9.
53. Haussler M, Whitfield G, Haussler C, et al. The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. JBMR 1998; 13: 325-49.
54. Mora JR, Iwata M, von Andrian UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 2008; 8: 685-98.
55. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005; 122: 107-18.
56. Wu H, Ivanov I, Darce J, et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010; 32: 815-27.
57. Dabrowska-Leonik N, Bernatowska E, Pac M, et al. Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency. Adv Med Sci 2018; 63: 173-8.
58. Xu J, Yang Y. Traditional Chinese Medicine in the Chinese health care system. Health Policy 2009; 90: 133-9.
59. Hesketh T, Zhu WX. Health in China: Traditional Chinese Medicine: one country, two systems. BMJ 1997; 315: 115-7.
60. Shi X, Zhu D, Nicholas S, Hong B, Man X, He P. Is Traditional Chinese Medicine “mainstream" in China? Trends in Traditional Chinese Medicine health resources and their utilization in Traditional Chinese Medicine hospitals from 2004 to 2016. Evid Based Complement Alternat Med 2020; 2020: 9313491.
61. Chen LJ, Yan SJ, Sang HS. Demand and utilization of TCM services in China. In: the editorial committee of Traditional Medicine and Human Health. Research on Medical and Health Policies, Regulations, and Laws. 2004: Proceedings of the 3rd International Conference of Traditional Medicine 2004 Nov 13-15; Beijing, China. Beijing: Traditional Chinese Medicine Ancient Literature Publishing House, 2004: 290-1.
62. Weng YX, Cen YY, Ou HP. Application of children massage combined with family participation nursing in children health care. Wei Liang Yuan Su Yu Jian Kang Yan Jiu 2020; 37: 83-4.
63. Guo XL. The value of children's massage combined with family participation nursing in children's health care. Guo Ji Gan Ran Bing Xue 2019; 8: 155.
64. Zhu AN, Miao YF, Lin T, et al. Discussion on the participation of infantile massage in community health care. Guangming Zhong Yi 2015; 30: 2009-12.
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