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Journal of Traditional Chinese Medicine >

2024 , Vol. 44 >Issue 3: 581 - 585

DOI: https://doi.org/10.19852/j.cnki.jtcm.20240402.005

Original articles

Neiguan (PC6) acupoint stimulation for preventing chemotherapy-induced nausea and vomiting: a cost-effective supplement in guideline-inconsistent chemotherapy-induced nausea and vomiting prophylaxis subgroup

  • Wenxi YU ,
  • Lina TANG ,
  • Hongtao LI ,
  • Yonggang WANG ,
  • Zan SHEN
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  • Department of Oncology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China

Received date: 2023-01-22

  Accepted date: 2023-05-25

  Online published: 2024-04-02

Supported by

National and Natural Science Foundation of China: DGKZ Acts as a Potential Oncogene in Osteosarcoma Proliferation through Interaction with ERK1/2 and MYC Pathway(Grant Number 81972521)

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Abstract

OBJECTIVE: To assess the efficacy and safety of Neiguan (PC6) acupoint acustimulation in preventing chemotherapy-induced nausea and vomiting (CINV), especially for patients with guideline-inconsistent CINV prophylaxis (GICP) due to personal reasons

METHODS: From January 2021 to December 2021, 373 patients suffered from solid malignancy were recruited according to the inclusion criteria. Complete response (no emesis and no rescue medication use) rate during the overall phase (0-120 h of each chemo-cycle) was the primary assessment of CINV control. The Functional Living Index-Emesis (FLIE) questionnaire was investigated among these patients as a secondary ‘quality of life’ objective to assess the impact of CINV on patients’ daily life by recording score of nausea and vomiting.

RESULTS: With acustimulation of Neiguan (PC6) acupuncture point through a portable, noninvasive and user-friendly device, in terms of complete response rate and scores in nausea/vomiting by FLIE questionnaire, patients achieve a better outcome in highly emetogenic chemotherapy (HEC) induced CINV, especially GICP subgroup. Meanwhile, analysis also demonstrated this tendency existed in other patients with HEC/GCCP (guideline consistent CINV prophylaxis) and moderate emetogenic chemotherapy, although the difference was not significant.

CONCLUSION: Considering advantages of Neiguan (PC6) acustimulation such as noninvasive, covered by medical insurance and few side effects, we believe it would be an ideal auxiliary tool in CINV control, especially in patients who receive highly emetogenic chemo-protocol and are reluctant to GCCP for economic reasons.

Key words： acupuncture; acustimulation; tumor; chemotherapy-induced nausea and vomiting

Cite this article

Wenxi YU , Lina TANG , Hongtao LI , Yonggang WANG , Zan SHEN . Neiguan (PC6) acupoint stimulation for preventing chemotherapy-induced nausea and vomiting: a cost-effective supplement in guideline-inconsistent chemotherapy-induced nausea and vomiting prophylaxis subgroup[J]. Journal of Traditional Chinese Medicine, 2024 , 44(3) : 581 -585 . DOI: 10.19852/j.cnki.jtcm.20240402.005

References

1. Soefje SA. Strategies to improve CINV outcomes in managed care. Am J Manag Care 2018; 24: S398-404.
2. Gu L, Li J. The assessment and management of chemotherapy-induced nausea and vomiting among cancer patients in a chemotherapy ward: a best practice implementation project. JBI Database System Rev Implement Rep 2016; 14: 235-46.
3. Hesketh PJ, Palmas M, Nicolas P. Preventing chemotherapy-induced nausea and vomiting in patients with lung cancer: efficacy of NEPA (netupitant-palonosetron), the first combination antiemetic. Support Care Cancer 2018; 26: 1151-59.
4. McCullough SW. Chemotherapy-induced nausea and vomiting: roles of pharmacists and formulary decision makers. Am J Manag Care 2017; 23: S266-71.
5. Herrstedt J, Clark-Snow R, Ruhlmann CH, et al. MASCC/ESMO antiemetic guidelines: introduction to the 2023 guidelines update. Support Care Cancer 2023; 32: 57.
6. Kirkegaard S, Kloth DD, Lagman R, et al. NCCN guidelines insights: antiemesis, version 2. 2017. J Natl Compr Canc Netw 2017; 15: 883-93.
7. Clark-Snow R, Affronti ML, Rittenberg CN. Chemotherapy induced nausea and vomiting (CINV) and adherence to antiemetic guidelines: results of a survey of oncology nurses. Support Care Cancer 2018; 26: 557-64.
8. Dielenseger P, B?rjeson S, Vidall C, et al. Evaluation of antiemetic practices for prevention of chemotherapy-induced nausea and vomiting (CINV): results of a European oncology nurse survey. Support Care Cancer 2019; 27: 4099-106.
9. Aapro M, Scotté F, Escobar Y, et al. Practice patterns for prevention of chemotherapy-induced nausea and vomiting and antiemetic guideline adherence based on real-world prescribing data. Oncologist 2021; 26: e1073-82.
10. Athavale A, Athavale T, Roberts DM. Antiemetic drugs: what to prescribe and when. Aust Prescr 2020; 43: 49-56.
11. Konno R. Cochrane review summary for cancer nursing: acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cancer Nurs 2010; 33: 479-80.
12. Xu X. The clinical observation of preventing vomiting after chemotherapy by Chinese herbal plaster on Yongquan acupoint. Shi Yong Zhong Yi Yao Za Zhi 2002; 9: 29.
13. Treish I, Shord S, Valgus J, et al. Randomized double-blind study of the Reliefband as an adjunct to standard antiemetics in patients receiving moderately-high to highly emetogenic chemotherapy. Support Care Cancer 2003; 11: 516-21.
14. Guo WC, Wang F. Effect of nerve electrical stimulation for treating chemotherapy-induced nausea and vomiting in patients with advanced gastric cancer: a randomized controlled trial. Medicine (Baltimore) 2018; 97: e13620.
15. Li WH, Li D. Effect of electrical stimulation for chemotherapy-induced nausea and vomiting in patients with liver cancer. Medicine (Baltimore) 2019; 98: e15255.
16. Dundee JW, McMillan C. Positive evidence for Neiguan (PC6) acupuncture antiemesis. Postgrad Med J 1991; 67: 417-22.
17. Shen Y, Liu L, Chiang JS, et al. Randomized, placebo-controlled trial of K1 acupoint acustimulation to prevent cisplatin-induced or oxaliplatin-induced nausea. Cancer 2015; 121: 84-92.
18. Roscoe JA, Matteson SE, Morrow GR, et al. Acustimulation wrist bands are not effective for the control of chemotherapy-induced nausea in women with breast cancer. J Pain Symptom Manage 2005; 29: 376-84.
19. Garcia GT, Ribeiro RF, Faria Santos IB, et al. Electrical stimulation of PC 6 to control chemotherapy-induced nausea and vomiting in patients with cancer: a systematic review and Meta-analysis. Med Acupunct 2021; 33: 22-44.
20. Navari RM, Schwartzberg LS. Evolving role of neurokinin 1-receptor antagonists for chemotherapy-induced nausea and vomiting. Onco Targets Ther 2018; 11: 6459-78.
21. Cada DJ, Leonard J, Baker DE. Netupitant/palonosetron. Hosp Pharm 2015; 50: 310-25.
22. Tran N Le, Michael T Adler, Holly Ouillette, et al. Observational case series evaluation of the granisetron transdermal patch system (Sancuso) for the management of nausea/vomiting of pregnancy. Am J Perinatol 2017; 34: 851-55.
23. Lindley CM, Hirsch JD, O'Neill CV, et al. Quality of life consequences of chemotherapy-induced emesis. Qual Life Res 1992; 1: 331-40
24. Clark-Snow R, Affronti ML, Rittenberg CN. Chemotherapy induced nausea and vomiting (CINV) and adherence to antiemetic guidelines: results of a survey of oncology nurses. Support Care Cancer 2018; 26: 557-64.
25. Aapro M, Caprariu Z, Chilingirov P, et al. Assessing the impact of antiemetic guideline compliance on prevention of chemotherapy-induced nausea and vomiting: results of the nausea/emesis registry in oncology (NERO). Eur J Cancer 2022; 166: 126-13.
26. Nunley C, Wakim J, Guinn C. The effects of stimulation of acupressure point Neiguan (PC6) on postoperative nausea and vomiting: a review of literature. J Perianesth Nurs 2008; 23: 247-61.
27. Chernyak GV, Sessler DI. Perioperative acupuncture and related techniques. Anesthesiology 2005; 102: 1031-49.
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