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Journal of Traditional Chinese Medicine >

2024 , Vol. 44 >Issue 3: 515 - 523

DOI: https://doi.org/10.19852/j.cnki.jtcm.20240423.006

Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang (Radix Et Rhizoma Rhei Palmati)-Taoren (Semen Persicae) herb pair

  • Xiang WANG ,
  • Jianping HUANG ,
  • Yupeng WANG ,
  • Qilong WANG ,
  • Yajiang JING ,
  • Gang ZHANG ,
  • Liang PENG ,
  • Jing GAO ,
  • Hongyan WANG ,
  • Yonggang YAN
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  • 1 Department of Key Laboratory of "Qin Pharmaceutical" Research and Development, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
    2 Department of Acupuncture and Tuina, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
    3 Department of Yupeng Shaanxi Haitian Pharmaceutical Co., Ltd., Xianyang 712000, China
Prof. YAN Yonggang, School of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China. yunfeng828@163.com Telephone: +86-13759845952; +86-13892062171
Lecturer WANG Hongyan, College of Acupuncture and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, China. Fengyun8817@163.com;

Received date: 2023-02-22

  Accepted date: 2023-07-14

  Online published: 2024-04-30

Supported by

National Major Natural Science Foundation Project: Study on the Dose-effect Relationship and Compatibility Mechanism of Core Medicine in Taohe Chengqi Decoction Prescription on "Removing Stasis And Dissipating Heat" of Taoren Rhubarb(81973592);Project of the Administration of Traditional Chinese Medicine of Shaanxi Province: Study on the Compatibility of the Classic Prescription Taohe Chengqi Decoction "Expelling Stasis And Expelling Heat" Based on Drug Interaction(2021-GJ-JC004);Discipline Innovation Team Project on Quality Evaluation and Resource Development of "Qin Medicine", Shaanxi University of Chinese Medicine(2019-QN01)

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Abstract

OBJECTIVE: To explore the material basis of the difference of efficacy of Dahuang (Radix Et Rhizoma Rhei Palmati)-Taoren (Semen Persicae) (DT) drugs with different proportions.

METHODS: Samples of different ratios of Dahuang (Radix et Rhizoma Rhei Palnati, DH) to Taoren (Semen Persicae, TR) (Group A 1:1, B 2:3, C 3:2) were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique.

RESULTS: A total of 240 primary metabolites were detected. Forty-one differential metabolites involved nine differential metabolic pathways, of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome. These pathways included the biosynthesis of amino acid (phenylalanine tyrosine and tryptophan), flavonoids, unsaturated fatty acids, and the glycolysis/glycogenesis pathway.

CONCLUSION: There are significant differences in the efficacy of different ratios of DT drugs, and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1:1.

Key words： metabolomics; metabolic networks and pathways; differential metabolites; Dahuang (Radix Et Rhizoma Rhei Palmati); Taoren (Semen Persicae); kernel drug pairs

Cite this article

Xiang WANG , Jianping HUANG , Yupeng WANG , Qilong WANG , Yajiang JING , Gang ZHANG , Liang PENG , Jing GAO , Hongyan WANG , Yonggang YAN . Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang (Radix Et Rhizoma Rhei Palmati)-Taoren (Semen Persicae) herb pair[J]. Journal of Traditional Chinese Medicine, 2024 , 44(3) : 515 -523 . DOI: 10.19852/j.cnki.jtcm.20240423.006

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