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Journal of Traditional Chinese Medicine >

2023 , Vol. 43 >Issue 6: 1227 - 1233

DOI: https://doi.org/10.19852/j.cnki.jtcm.20231008.001

Research Articles

Effectiveness of Shenshu Guanxin recipe granules (参术冠心方颗粒) for improving exercise tolerance in patients with stable angina pectoris: a randomized, double-blind, placebo-controlled trial

  • Xiao JIN ,
  • Bingxin WU ,
  • Huanlin WU ,
  • Danping XU
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  • 1 Department of Traditional Chinese Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
    2 Department of Cardiology, Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510000, China
    3 Department of Cardiology, Dongzhimen Hosipital, Beijing 100029, China
    4 Department of Traditional Chinese Medicine, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China

Received date: 2022-02-12

  Accepted date: 2022-05-13

  Online published: 2023-10-08

Supported by

Exploring the Mechanism of Shenshu Guanxin Formula in Intervention of Myocardial Ischemia Based on MiR-24 Mediated Bim/Caspase Apoptosis Signal Pathway(A2021349);Exploring the Intervention of Shenshu Guanxin Formula on Myocardial Ischemia Based on MiR-24 Mediated Bim/Caspase Apoptosis Signal Pathway Mechanism Research(21621062);to Study the Mechanism of Hesperidin in Improving Heart Failure Based on Myocardial Inflammation Mediated by MtDNA-sGAS-STING Signaling Pathway(JCYJ20220530144212026)

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Abstract

OBJECTIVE: To assess the effectivess of Shenshu Guanxin recipe granules (参术冠心方颗粒, SGR) in improving exercise tolerance and the quality of life in patients with Stable Angina Pectoris (SAP).
METHODS: A total of 189 patients were consecutively enrolled between December 2012 and December 2014. The included patients were randomly assigned to SGR and placebo groups. The primary endpoints included mainly the results of treadmill exercise test and Seattle Angina Questionnaire (SAQ) during 12 weeks of treatment.
RESULTS: After 12 weeks of treatment, SGR extended the time of exercise-induced ST-segment depression of 0.1 MV, lowered the maximum ST-segment depression, and shortened the duration of ST-segment depression in patients with SAP in southern China. Besides, the study also proved that SGR could improve the quality of life and functional status of patients with SAP.
CONCLUSIONS: SGR showed a positive effect on exercise tolerance compared with the placebo besides optimal medical therapy. Also, the study proved that SGR could improve the SAQ score of the patients.

Key words： exercise tolerance; angina, stable; Seattle Angina Questionnaire; Shenshu Guanxin recipe granules

Cite this article

Xiao JIN , Bingxin WU , Huanlin WU , Danping XU . Effectiveness of Shenshu Guanxin recipe granules (参术冠心方颗粒) for improving exercise tolerance in patients with stable angina pectoris: a randomized, double-blind, placebo-controlled trial[J]. Journal of Traditional Chinese Medicine, 2023 , 43(6) : 1227 -1233 . DOI: 10.19852/j.cnki.jtcm.20231008.001

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