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Journal of Traditional Chinese Medicine >

2023 , Vol. 43 >Issue 5: 934 - 943

DOI: https://doi.org/10.19852/j.cnki.jtcm.20230630.001

Efficacy of verbascoside, echinacoside, crenatoside on altitude-induced fatigue in rats and possible mechanism

  • Ziliang GUO ,
  • Qingyuan QIAN ,
  • Xiaolin LI ,
  • Yuting ZHU ,
  • Jun REN ,
  • Maoxing LI
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  • 1 College of Pharmacy, Lanzhou University, Lanzhou 730030, China
    2 Department of Pharmacy, the 940th Hospital of Joint Logistic Support Force of Chinese of the People's Liberation Army, Lanzhou 730050, China
    3 College of Pharmacy, Lanzhou University, Lanzhou 730030, China
    4 Department of Pharmacy, the 940th Hospital of Joint Logistic Support Force of Chinese of the People's Liberation Army, Lanzhou 730050, China
    5 Department of Pharmacy, 3201 Hospital, Hanzhong 723000, China
    6 Department of Pharmacy, the 940th Hospital of Joint Logistic Support Force of Chinese of the People's Liberation Army, Lanzhou 730050, China
    7 Department of Pharmacy, the 940th Hospital of Joint Logistic Support Force of Chinese of the People's Liberation Army, Lanzhou 730050, China
    8 College of Pharmacy, Lanzhou University, Lanzhou 730030, China

Received date: 2022-06-19

  Accepted date: 2022-09-01

  Online published: 2023-06-30

Supported by

Logistics Research Projects: the Project of Preparation of Crocetin Nanoparticles and Study on the Mechanism of Enhancing the Efficiency of Military Operations at High Altitude(CLB21J036);Top Cultivation Project: the Role of Crocetin in Improving Military Operations Efficiency in High Altitude Hypoxic Environments(2021yxky001);Youth Cultivation Project: Screening and Mechanism Study of Phenylethanol Glycosides and Their Metabolites Against High Altitude Hypoxia Activity(2021yxky060);Open Fund Project of the Collaborative Innovation Center Jointly Constructed by the Northwest China Tibet Medicine Province and Ministry: the Open Foundation of Northwest Collaborative Innovation Center for Traditional Chinese Medicine Co-constructed by Gansu Province and MOE of PRC(Xbzzy-2022-06);Gansu Provincial Health Industry Research Project: Study on the Anti-Hypoxia and Anti-fatigue Effects and Mechanisms of Crocin(GSWSKY2020-41);National Youth Fund: Study on the Dual Regulation of Vascular Endothelial Homeostasis Based on the PI3K/Akt Pathway-the Mechanism of Action of Z-myristosterone against Ischemic Stroke(82003982)

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Abstract

OBJECTIVE: To study the efficacy and mechanism of three phenylethanoid glycosides (PhGs) (verbascoside, echinacoside, and crenatoside) on altitude-induced fatigue in rats.
METHODS: Altitude-induced fatigue model rats were established in a large hypobaric chamber. Swimming time, energy storage substances, metabolic enzymes, and metabolites were used to evaluate the anti-fatigue activities and mechanism of three PhGs (verbascoside, echinacoside, and crenatoside) (150 mg/kg, intragastric administration) in the hypoxic environment.
RESULTS: The three PhGs, especially verbascoside, could prolong the swimming time of rats, ameliorate the edema and inflammatory infiltration of liver and skeletal muscle, increase the level of energy storage substances, reduce the decomposition of proteins, and exhibit positive effects on the metabolism-related enzyme activity and metabolites.
CONCLUSIONS: The PhGs, especially verbascoside, are very potential with anti-fatigue activity in hypoxia. The mechanism may be explained with regulation of energy metabolism and reduction of oxidative stress.

Key words： phenylethanoid glycosides; verbascoside; hypoxia; fatigue; energy metabolism

Cite this article

Ziliang GUO , Qingyuan QIAN , Xiaolin LI , Yuting ZHU , Jun REN , Maoxing LI . Efficacy of verbascoside, echinacoside, crenatoside on altitude-induced fatigue in rats and possible mechanism[J]. Journal of Traditional Chinese Medicine, 2023 , 43(5) : 934 -943 . DOI: 10.19852/j.cnki.jtcm.20230630.001

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