Meta Analysis

Acupoint catgut embedding for simple obesity in animal studies: a systematic review and Meta-analysis

  • HuiYan ZHAO ,
  • Purumea JUN ,
  • Chaewon LEE ,
  • Chang-Hyun HAN
Expand
  • 1 Korean Convergence Medical Science, University of Science and Technology (UST), School of Korea Institute of Oriental Medicine
    2 Daejeon 34054, Republic of Korea; KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea
    3 KM Data Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea
    4 St. Johnsbury Academy Jeju, 304, Global edu-ro, Daejeong-eup, Seogwipo-si 63644, Republic of Korea
    5 Korean Convergence Medical Science, University of Science and Technology (UST), School of Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea
    6 KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea

Received date: 2022-09-16

  Accepted date: 2022-12-27

  Online published: 2023-08-28

Supported by

Korea Institute of Oriental Medicine(KSN1823211);Korea Institute of Oriental Medicine(KSN20234115)

Abstract

OBJECTIVE: To assess the efficacy of acupoint catgut embedding (ACE) for simple obesity in preclinical animal experiments.
METHODS: We searched the following 14 electronic databases: PubMed, Cochrane Library, EMBASE, Oriental Medicine Advanced Searching Integrated System, KoreaMed, Korean Studies Information Service System, Science-on, Research Information Sharing Service, Korea Citation Index, Korea Traditional Knowledge Portal, China Network Knowledge Infrastructure Database, Wanfang Database, Chinese Science and Technology Journal Database, and Chinese Biology Medicine Database, from inception to November 2021 without language limitation. The assessment was performed according to the guidelines of Animal Research: Reporting of in vivo experiments; and Meta-analysis was performed using Reviewer Manager 5.4.1 software.
RESULTS: Twenty-four studies involving 813 animals were selected. Meta-analysis showed that ACE was beneficial for weight control [n = 40, MD = -50.63, 95% CI (-57.59, -43.67), P < 0.000 01, I 2 = 0%] and reduced the Lee index [n = 40, MD = -18.79, 95% CI (-20.01, -17.57), P < 0.000 01, I 2 = 0%]. However, when efficacy of ACE was compared with that of manual acupuncture, electroacupuncture, or oilistat therapy, statistical difference was not observed between the two groups.
CONCLUSIONS: This systematic review suggests that ACE may be efficacious in treating obesity. Moreover, the analyses highlighted the necessity to perform well-designed, higher-quality experiments.

Cite this article

HuiYan ZHAO , Purumea JUN , Chaewon LEE , Chang-Hyun HAN . Acupoint catgut embedding for simple obesity in animal studies: a systematic review and Meta-analysis[J]. Journal of Traditional Chinese Medicine, 2023 , 43(5) : 860 -867 . DOI: 10.19852/j.cnki.jtcm.2023.05.002

References

1. Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-43.
2. Nam GE, Kim YH, Han K, et al. Obesity fact sheet in Korea, 2019: prevalence of obesity and abdominal obesity from 2009 to 2018 and social factors. J Obes Metab Syndr 2020; 29: 124-32.
3. Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity and severe obesity among adults: United States, 2017-2018. NCHS Data Brief 2020; 360: 1-8.
4. Luhar S, Tim?us IM, Jones R, et al. Forecasting the prevalence of overweight and obesity in India to 2040. PLoS One 2020; 15: e0229438.
5. WHO. Obesity and overweight Fact sheet N. 2015-01-11, cited 2016-02-02. Available from URL: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
6. Bray GA, Frühbeck G, Ryan DH, Wilding JP. Management of obesity. Lancet 2016; 387: 1947-56.
7. Tremmel M, Gerdtham UG, Nilsson PM, Saha S. Economic burden of obesity: a systematic literature review. Int J Environ Res Public Health 2017; 14: 1-18.
8. Apovian C. Obesity: definition, comorbidities, causes, and burden. Am J Manag Care 2016; 22: s176-85.
9. Scheen AJ. Cardiovascular risk-benefit profile of sibutramine. Am J Cardiovasc Drugs 2010; 10: 321-34.
10. Singh S, Bazarbashi AN, Khan A, et al. Primary obesity surgery endoluminal (POSE) for the treatment of obesity: a systematic review and Meta-analysis. Surgical endoscopy 2021: 1-15.
11. Lee HY, Han CH, Lee YJ. A literature review on the study of thread embedding acupuncture in domestic and foreign journals-focus on clinical trials. JAMS 2016; 20: 93-113.
12. Ma CB, Yang CD. A review on acupoint catgut treatment. Zhong Yi Lin Chuang Yan Jiu 2019; 11: 21-3.
13. Huang CL. The curative effect observation and cost-benifit analysis of curing simple obesity by catgut embedding. Guangzhou: Guangzhou University of Chinese Medicine, 2009: 18-20.
14. Sheng J, Jin X, Zhu J, Chen Y, Liu X. The effectiveness of acupoint catgut embedding therapy for abdominal obesity: a systematic review and Meta-analysis. Evid Based Complement Alternat Med 2019; 2019: 9714313.
15. Guo T, Ren Y, Kou J, Shi J, Tian XS, Liang F. Acupoint catgut embedding for obesity: systematic review and Meta-analysis. Evid Based Complement Alternat Med 2015; 2015: 401914.
16. Hooijmans C, Ritskes-Hoitinga M. Progress in using systematic reviews of animal studies to improve translational research. PLoS Med 2013; 10: e1001482.
17. Salameh JP, Bossuyt PM, McGrath TA, et al. Preferred reporting items for systematic review and Meta-analysis of diagnostic test accuracy studies (PRISMA-DTA): explanation, elaboration, and checklist. BMJ 2020; 370: m2632.
18. Percie du Sert N, Hurst V, Ahluwalia A, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. J Cereb Blood Flow Metab 2020; 40: 1769-77.
19. Choe S, Cai M, Jerng UM, Lee JH. The efficacy and underlying mechanism of moxibustion in preventing cognitive impairment: a systematic review of animal studies. Exp Neurobiol 2018; 27: 1-15.
20. Inprasit C, Huang YC, Lin YW. Evidence for acupoint catgut embedding treatment and TRPV1 gene deletion increasing weight control in murine model. Int J Mol Med 2020; 45: 779-92.
21. Li XY, Liu ZD, Zhao C, Chen CL, Liang W. Effect of catgut embedding underneath points at different layers on metablisms of glucose and lipid in simple obesity rats. Zhen Jiu Lin Chuang Za Zhi 2017; 33: 52-6.
22. Deng M, Xu SS, Sun YN, Gong MR. Effects of acupoint catgut embedding therapy on fat reduction and the inflammatory factor in adipose tissues of the obese mice. Shi Zhen Guo Yi Guo Yao 2016; 27: 1277-9.
23. Li Y, Sa YP. Effect of catgut implantation at acupoint on adiponectin and its receptors for obesity rat model. Shi Jie Zhong Yi Yao 2015; 10: 1752-4, 9.
24. Liu BL, Wang LP, Chen FJ, Liu B, Lü CX. Experiment studies on treatment for pure fat rats by catgut suturing in 4 body acupoints. Zhong Hua Shi Yong Zhong Xi Za Zhi 2007; 20: 2091-3.
25. Meng XR, Zhu XS, Yang CY, Jing A, Tan QW, Yu HJ. Effect of Tianshu acupoint embedding on insulin resistance in obese rats. Zhen Jiu Lin Chuang Za Zhi 2019; 35: 64-7.
26. Pan FF, Zhao JP. Influence of acupoint catgut embedding on leptin and fat accumulate in simple obesity rats. Zhong Yi Lin Chuang Yan Jiu 2015; 7: 1-3.
27. Wu A. The clinical evaluation and laboratory studies with catgut embedding treatment for obesity. Guangzhou: Guangzhou University of Chinese Medicine, 2009: 32-5.
28. Yan LH, Liu XM, Bai J, Yu J, Gu JS. Study on the influence of catgut implantation at acupoint on simple obesity Leptin and insulin resistance. Zhong Guo Mei Rong Yi Xue 2012; 21: 490-4.
29. Yang SF, Wang YF. The effect of thread-embedding therapy on the content of NO and NOS in the striatum of obese rats. Zhejiang Zhong Yi Za Zhi 2008; 43: 380-1.
30. Yi YY, Jiang JZ, Liu ZC. Effect of acupoint catgut embedding on the expression of 3-AR protein in white adipose tissue of obese rats. Zhong Yi Xue Bao 2016; 31: 247-9.
31. Zhang LP. The Influence of penetration embedding method on the levels of serum leptin, blood lipids blood sugar in rats with diet-induced obesity. Henan: Henan University of Chinese Medicine, 2011: 12-5.
32. Zhang XM. Experimental study of acupuncture and embedded thread therapy on obesity. Guangzhou: Guangzhou University of Chinese Medicine, 2006: 32-5.
33. Zheng LL. Study on the impact of TC, TG and LDL-C, HDL-C and liver cells on the obesity fatty liver rats through catgut embedding therapy method. Henan: Henan TCM University, 2012: 11-3.
34. Wu XM, Hu XY, Sun Z, et al. Effects of catgut embedding at different levels on blood lipids and leptin in simple obese rats. Shi Zhen Guo Yi Guo Yao 2019; 30: 3054-5.
35. Hou XH, Yin GZ, Ma Q. Affection of indexes by acupoint catgut implantation treatment on experimental simple obesity rats. Xinjiang Yi Ke Da Xue Xue Bao 2008; 31: 31-3.
36. Gao L, Kong XJ, Shi X. Effects of electroacupuncture and acupoint catgut-embedding on mRNA expression of lipid metabolism gene PPAR-γ and related lipase of rats with simple obesity. Zhong Guo Zhen Jiu 2011; 31: 535-8.
37. Jiang JZ, Yi YL, Liu ZC. INSR protein expression on the hypothalamic arcuate nucleus of obese rats by catgut implantation at acupoint. Zhong Hua Zhong Yi Yao Xue Kan 2012; 30: 1822-5.
38. Wu J, Sun Y, Zhu X. Effects of acupoint catgut-embedding therapy on obese model rats and obesity-related genes. Dong Nan Da Xue Xue Bao 2019; 38: 812-7.
39. Li LL, Hu JP, Zhang SY, Xie YH. Effect of acupoint thread-embedding on macrophage polarization of epididymis adipose tissue in obese mice. Zhong Guo Zhen Jiu 2021; 41: 177-82.
40. Wang SX, Li YH. Effects of catgut-embedding at acupoint on contents of leptin and blood fat in obese rats. Tianjin Zhong Yi Yao 2009; 26: 63-5.
41. Tang HZ, Xia M. The effect of combined treatment in Chinese medicine on food consumption weight body fat weight in obese rats. Liaoning Zhong Yi Yao Da Xue Xue Bao 2009; 11: 164-6.
42. Liu B, Wang L, Chen F, Liu B, Lü C. Experiment studies on treatment for pure fat rats by catgut suturing in 4 body acupoints. Zhong Hua Shi Yong Zhong Xi Za Zhi 2007; 20: 2091-3.
43. Tang HZ. Effect of combined treatment in Chinese medicine on TC/TG in serum of obesity model rats. Shi Zhen Guo Yi Guo Yao 2010; 21: 1587-8.
Outlines

/