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Journal of Traditional Chinese Medicine >

2023 , Vol. 43 >Issue 5: 1040 - 1046

DOI: https://doi.org/10.19852/j.cnki.jtcm.20230727.003

Review

Protective effects of tanshinone ⅡA on sepsis-induced multiple organ dysfunction: a literature review

  • Lili WANG ,
  • Ju FENG ,
  • Daqian ZHAN ,
  • Junshuai WANG ,
  • Daixing ZHOU
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  • Emergency Department and Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Received date: 2022-06-12

  Accepted date: 2022-09-21

  Online published: 2023-08-28

Supported by

Natural Science Foundation of Hubei Province: Mechanism of Degenerative Aortic Valve Calcification Induced by Inflammatory Responses in Valvular Interstitial Cells(2020CFB577)

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Abstract

TanshinoneⅡA (TanⅡA) is a noteworthy lipophilic diterpene compound derived from the dried roots of the Traditional Chinese Medicine Danshen (Radix Salviae Miltiorrhizae) that has various pharmacological properties, including anti-inflammatory, antibacterial, and antioxidative effects. Sepsis is a life-threatening organ dysfunction induced by a dysregulated host response to infection. Recently, increasing attention has been paid to sepsis-induced dysfunction of the intestine, car-diovascular system, lungs, kidneys, liver, and other organs. Experimental studies have shown that TanⅡA has therapeutic potential for sepsis-induced organ dysfunction owing to its anti-inflammatory, anti-apoptotic and regulatory effects on multiple signalling pathways. The purpose of this article is to evaluate the potential multiorgan protective effects of TanⅡA in sepsis.

Key words： tanshinoneⅡA; sepsis; multiple organ failure; review

Cite this article

Lili WANG , Ju FENG , Daqian ZHAN , Junshuai WANG , Daixing ZHOU . Protective effects of tanshinone ⅡA on sepsis-induced multiple organ dysfunction: a literature review[J]. Journal of Traditional Chinese Medicine, 2023 , 43(5) : 1040 -1046 . DOI: 10.19852/j.cnki.jtcm.20230727.003

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