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Journal of Traditional Chinese Medicine >

2023 , Vol. 43 >Issue 3: 627 - 630

DOI: https://doi.org/10.19852/j.cnki.jtcm.20230308.002

Reviews

Transcutaneous auricular vagus nerve stimulation would be an alternative to implantable cervical vagus nerve stimulation in some situation

  • Jiakai HE ,
  • Jinling ZHANG ,
  • Yu WANG ,
  • Shaoyuan LI ,
  • Jiliang FANG ,
  • Shuai ZHANG ,
  • Yanan ZHAO ,
  • Weihang ZHAI ,
  • Deqiang GAO ,
  • Ran LI ,
  • Yuhang JIANG ,
  • Zehao CHEN ,
  • Baohui JIA ,
  • Peijing RONG
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  • 1 Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
    2 Department of Physical Medicine and Rehabilitation, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

Received date: 2022-02-12

  Accepted date: 2022-06-22

  Online published: 2023-03-08

Supported by

China Academy of Chinese Medical Sciences Innovation Fund: Brain Effects and Multimodal Imaging Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation in Patients with Disorder of Consciousness(CI2021A03305);National Key Research and Development Program: Optimization and Effect Mechanism of Transcutaneous Electrical Cranial-auricular Acupoint Stimulation (TECAS) on Depression(2018YFC1705800)

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Abstract

Implantable cervical vagus nerve stimulation (iVNS) is a representative and promising neuromodulation. However, the invasive nature restricts its application. Traditional auricular acupuncture treatment has a long history. The auricular branch of the vagus nerve (ABVN) is a branch on the surface of the ear. Some studies demonstrates that transcutaneous auricular vagus nerve stimulation (taVNS) would achieve similar effects as iVNS. TaVNS and iVNS share a common anatomical basis and acting mechanism. In this article, we made a comparison between iVNS and taVNS in indications and efficacy. The recent studies have revealed similar clinical efficacy of taVNS, taVNS would expand the indication of iVNS. High-quality clinical evidences are needed before taVNS become be an alternative of iVNS.

Key words： transcutaneous auricular vagus nerve stimulation; auricular branch of vagus nerve; neuromodulation; efficacy

Cite this article

Jiakai HE , Jinling ZHANG , Yu WANG , Shaoyuan LI , Jiliang FANG , Shuai ZHANG , Yanan ZHAO , Weihang ZHAI , Deqiang GAO , Ran LI , Yuhang JIANG , Zehao CHEN , Baohui JIA , Peijing RONG . Transcutaneous auricular vagus nerve stimulation would be an alternative to implantable cervical vagus nerve stimulation in some situation[J]. Journal of Traditional Chinese Medicine, 2023 , 43(3) : 627 -630 . DOI: 10.19852/j.cnki.jtcm.20230308.002

References

[1] Wang Y, Li SY, Wang D, et al. Transcutaneous auricular vagus nerve stimulation: from concept to application. Neurosci Bull 2021; 37: 853-62.
[2] Butt MF, Albusoda A, Farmer AD, Aziz Q. The anatomical basis for transcutaneous auricular vagus nerve stimulation. J Anat 2020; 236: 588-611.
[3] Elliott RE, Morsi A, Geller EB, Carlson CC, Devinsky O, Doyle WK. Impact of failed intracranial epilepsy surgery on the effectiveness of subsequent vagus nerve stimulation. Neurosurgery 2011; 69: 1210-17.
[4] Ben-Menachem E, Ma?on-Espaillat R, Ristanovic R, et al. Vagus nerve stimulation for treatment of partial seizures: 1. a controlled study of effect on seizures. Epilepsia 1994; 35: 616-26.
[5] Handforth a, DeGiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures. Neurology 1998; 51: 48-55.
[6] Terra VC, Furlanetti LL, Nunes AA, et al. Vagus nerve stimulation in pediatric patients: Is it really worthwhile? Epilepsy Behav 2014; 31: 329-33.
[7] Hamer HM, Bauer S. Lessons learned from transcutaneous vagus nerve stimulation (tVNS). Epilepsy Res 2019; 153: 83-4.
[8] Chrastina J, Novak Z, Zeman T, et al. Single-center long-term results of vagus nerve stimulation for epilepsy: a 10-17 year follow-up study. Seizure 2018; 59: 41-7.
[9] Rong P, Liu J, Wang L, et al. Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder: a nonrandomized controlled pilot study. J Affect Disord 2016; 195: 172-9.
[10] Song GF, Wang HY, Wu CJ, Li X, Yang FY. A retrospective study of transcutaneous vagus nerve stimulation for poststroke epilepsy. Medicine (United States) 2018; 97: e11625.
[11] George MS, Sackeim HA, Marangell LB, et al. Vagus nerve stimulation: a potential therapy for resistant depression? Psychiatr Clin North Am 2000; 23: 757-83.
[12] Conway CR, Gebretsadik MD, Bucholz RD. Marked response to VNS in a post-cingulotomy patient: implications for the mechanism of action of VNS in TRD. CNS Spectr 2011; 16: 135-41.
[13] Hein E, Nowak M, Kiess O, et al. Auricular transcutaneous electrical nerve stimulation in depressed patients: a randomized controlled pilot study. J Neural Transm 2013; 120: 821-7.
[14] Aaronson ST, Sears P, Ruvuna F, et al. A 5-year observational study of patients with treatment-resistant depression treated with vagus nerve stimulation or treatment as usual: comparison of response, remission, and suicidality. Am J Psychiatry 2017; 174: 640-8.
[15] Sackeim HA, Rush AJ, George MS, et al. Vagus nerve stimulation (VNSTM) for treatment-resistant depression: efficacy, side effects, and predictors of outcome. Neuropsychopharmacology 2001; 25: 713-28.
[16] Bottomley JM, LeReun C, Diamantopoulos A, Mitchell S, Gaynes BN. Vagus nerve stimulation (VNS) therapy in patients with treatment resistant depression: a systematic review and Meta-analysis. Compr Psychiatry 2020; 98: 152156.
[17] Katagiri M, Iida K, Kagawa K, et al. Combined surgical intervention with vagus nerve stimulation following corpus callosotomy in patients with Lennox-Gastaut syndrome. Acta Neurochir (Wien) 2016; 158: 1005-12.
[18] Thibert RL, Conant KD, Braun EK, et al. Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options. Epilepsia 2009; 50: 2369-76.
[19] Mikati MA, Tabbara F. Managing Lafora body disease with vagal nerve stimulation. Epileptic Disorders 2017; 19: 82-6.
[20] Dibué-Adjei M, Brigo F, Yamamoto T, Vonck K, Trinka E. Vagus nerve stimulation in refractory and super-refractory status epilepticus - a systematic review. Brain Stimul 2019; 12: 1101-10.
[21] Fernandez L, Gedela S, Tamber M, Sogawa Y. Vagus nerve stimulation in children less than 3 years with medically intractable epilepsy. Epilepsy Res 2015; 112: 37-42.
[22] Gedela S, Sitwat B, Welch WP, Krafty RT, Sogawa Y. The effect of vagus nerve stimulator in controlling status epilepticus in children. Seizure 2018; 55: 66-9.
[23] Koenig J, Parzer P, Haigis N, et al. Effects of acute transcutaneous vagus nerve stimulation on emotion recognition in adolescent depression. Psychol Med 2021; 51: 511-20.
[24] Wu C, Liu P, Fu H, et al. Transcutaneous auricular vagus nerve stimulation in treating major depressive disorder a systematic review and Meta-analysis. Medicine (United States) 2018; 97: e13845.
[25] Capilupi MJ, Kerath SM, Becker LB. Vagus nerve stimulation and the cardiovascular system. Cold Spring Harb Perspect Med 2020; 10: a034173.
[26] Zhou L, Filiberti A, Humphrey MB, et al. Low-level transcutaneous vagus nerve stimulation attenuates cardiac remodelling in a rat model of heart failure with preserved ejection fraction. Exp Physiol 2019; 104: 28-38.
[27] Schwartz PJ. Vagal stimulation for the treatment of heart failure: a translational success story. Heart 2012; 98: 1687-9.
[28] de Ferrari GM, Crijns HJGM, Borggrefe M, et al. Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure. Eur Heart J 2011; 32: 847-55.
[29] Hani N. Sabbah. Vagus nerve stimulation for the treatment of heart failure:from cell to bedside (seventh edition). Philadelphia, PA: Elsevier, 2018, 2: 1316-22.
[30] Antonino D, Teixeira AL, Maia-Lopes PM, et al. Non-invasive vagus nerve stimulation acutely improves spontaneous cardiac baroreflex sensitivity in healthy young men: a randomized placebo-controlled trial. Brain Stimul 2017; 10: 875-81.
[31] Tobaldini E, Toschi-Dias E, de Souza LA, et al. Cardiac and peripheral autonomic responses to orthostatic stress during transcutaneous vagus nerve stimulation in healthy subjects. J Clin Med 2019; 8: 496.
[32] M?ller M, Schroeder CF, May A. Vagus nerve stimulation modulates the cranial trigeminal autonomic reflex. Ann Neurol 2018; 84: 886-92.
[33] M?ller M, May A. The unique role of the trigeminal autonomic reflex and its modulation in primary headache disorders. Curr Opin Neurol 2019; 32: 438-42.
[34] Rimmele F, Jürgens TP. Neuromodulation in primary headaches: current evidence and integration into clinical practice. Curr Opin Neurol 2020; 33: 329-37.
[35] Straube A, Ellrich J, Eren O, Blum B, Ruscheweyh R. Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial. J Headache Pain 2015; 16: 543.
[36] Broncel A, Bocian R, K?os-Wojtczak P, Kulbat-Warycha K, Konopacki J. Vagal nerve stimulation as a promising tool in the improvement of cognitive disorders. Brain Res Bull 2020; 155: 37-47.
[37] Cai L, Lu K, Chen X, Huang JY, Zhang BP, Zhang H. Auricular vagus nerve stimulation protects against postoperative cognitive dysfunction by attenuating neuroinflammation and neurodegeneration in aged rats. Neurosci Lett 2019; 703: 104-10.
[38] Vonck K, Raedt R, Naulaerts J, et al. Vagus nerve stimulation...25 years later! What do we know about the effects on cognition? Neurosci Biobehav Rev 2014; 45: 63-71.
[39] Jiang Y, Cao Z, Ma H, et al. Auricular vagus nerve stimulation exerts antiinflammatory effects and immune regulatory function in a 6-OHDA model of Parkinson’s disease. Neurochem Res 2018; 43: 2155-64.
[40] Clark KB, Naritoku DK, Smith DC, Browning RA, Jensen RA. Enhanced recognition memory following vagus nerve stimulation in human subjects. Nat Neurosci 1999; 2: 94-8.
[41] Mondal B, Choudhury S, Simon B, Baker MR, Kumar H. Noninvasive vagus nerve stimulation improves gait and reduces freezing of gait in Parkinson’s disease. Movement Disorders 2019; 34: 917-8.
[42] Morris R, Yarnall AJ, Hunter H, Taylor JP, Baker MR, Rochester L. Noninvasive vagus nerve stimulation to target gait impairment in Parkinson’s disease. Movement Disorders 2019; 34: 918-9.
[43] Lehtim?ki J, Hyv?rinen P, Ylikoski M, et al. Transcutaneous vagus nerve stimulation in tinnitus: a pilot study. Acta Otolaryngol 2013; 133: 378-82.
[44] Kreuzer PM, Landgrebe M, Resch M, et al. Feasibility, safety and efficacy of transcutaneous vagus nerve stimulation in chronic tinnitus: an open pilot study. Brain Stimul 2014; 7: 740-7.
[45] Yin J, Ji F, Gharibani P, Chen JD. Vagal nerve stimulation for glycemic control in a rodent model of type 2 diabetes. Obes Surg 2019; 29: 2869-77.
[46] Wang S, Zhai X, Li S, McCabe MF, Wang X, Rong P. Transcutaneous vagus nerve stimulation induces tidal melatonin secretion and has an antidiabetic effect in Zucker fatty rats. PLoS One 2015; 10: e0124195.
[47] Li S, Sun C, Rong P, et al. Auricular vagus nerve stimulation enhances central serotonergic function and inhibits diabetic neuropathy development in Zucker fatty rats. Mol Pain 2018; 14: 1744806918787368.
[48] Huang F, Dong J, Kong J, et al. Effect of transcutaneous auricular vagus nerve stimulation on impaired glucose tolerance: a pilot randomized study. BMC Complement Altern Med 2014: 26: 203.
[49] He J, Yang Y, Wang L, et al. Transcutaneous auricular vagus nerve stimulation in disorders of consciousness monitored by fMRI: the first case report. Brain Stimul 2017; 10: 328-30.
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