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Journal of Traditional Chinese Medicine >

2023 , Vol. 43 >Issue 3: 588 - 593

DOI: https://doi.org/10.19852/j.cnki.jtcm.20230404.004

Original Articles

Noninvasive identificational diagnosis of diabetic nephropathy and non-diabetic renal disease based on clinical characteristics of Traditional Chinese Medicine symptom pattern and conventional medicine

  • Yilun QU ,
  • Haimei CHENG ,
  • Qian WANG ,
  • Shuang LI ,
  • Shuwei DUAN ,
  • Zhe FENG ,
  • Weizhen LI ,
  • Shuangshuang JIANG ,
  • Hongtao YANG ,
  • Yonghui MAO ,
  • Yanqiu GENG ,
  • Jijun LI ,
  • Yuning LIU ,
  • Jinzhou TIAN ,
  • Hongfang LIU ,
  • Zheyi DONG ,
  • Xiangmei CHEN
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  • 1 Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China
    2 Department of Nephrology, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
    3 Department of Nephrology, Beijing Hospital, Beijing 100730, China
    4 Department of Nephrology, the Third Medical Center of PLA General Hospital, Beijing 100039, China
    5 Department of Nephrology, the Forth Medical Center of PLA General Hospital, Beijing 100048, China
    6 Department of Nephrology, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China
    7 Three Departments of Encephalopathy, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China
    8 Department of Endocrinology, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China
Dr. DONG Zheyi, Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China
Prof. CHEN Xiangmei, Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China. xmchen301@126.com;

Received date: 2022-03-25

  Accepted date: 2022-06-15

  Online published: 2023-04-04

Supported by

Study on the Core Pathogenesis and Clinical Evolution of Damp-heat Symptom in Diabetic Nephropathy(2018YFC1704203);Key Technologies and Varieties Development of New TCM Drugs Based on Big Data(2019Zx09201-005);Correlation between Clinical Phenotype and Pathological Diagnosis of Type 2 Diabetic Nephropathy(D171100002817002);Effect of miR-155 on Inhibition of Macrophage Autophagy by mTOR in Diabetic Nephropathy(81700629)

Fold

Abstract

OBJECTIVE: To study the clinical characteristics relating to differential diagnosis of diabetic nephropathy (DN) and non-diabetic renal disease (NDRD).

METHODS: The subjects were patients with type 2 diabetes mellitus (T2DM) complicated with chronic kidney disease (CKD). Western medical history data and Traditional Chinese Medicine (TCM) symptom pattern were collected, and logistic regression was used to analyze.

RESULTS: Blood deficiency pattern [odds ratio (OR) = 2.269, P = 0.017] and Qi stagnation pattern (OR = 1.999, P = 0.041) are independently related to DN.

CONCLUSIONS: TCM factors blood deficiency pattern and Qi stagnation pattern are relating to differential diagnosis of DN and NDRD.

Key words： diabetes mellitus, type 2; renal insufficiency, chronic; diabetic nephropathies; non-diabetic renal disease; syndrome complex

Cite this article

Yilun QU , Haimei CHENG , Qian WANG , Shuang LI , Shuwei DUAN , Zhe FENG , Weizhen LI , Shuangshuang JIANG , Hongtao YANG , Yonghui MAO , Yanqiu GENG , Jijun LI , Yuning LIU , Jinzhou TIAN , Hongfang LIU , Zheyi DONG , Xiangmei CHEN . Noninvasive identificational diagnosis of diabetic nephropathy and non-diabetic renal disease based on clinical characteristics of Traditional Chinese Medicine symptom pattern and conventional medicine[J]. Journal of Traditional Chinese Medicine, 2023 , 43(3) : 588 -593 . DOI: 10.19852/j.cnki.jtcm.20230404.004

References

[1] De Boer IH, Rue TC, Hall YN, Heagerty PJ, Weiss NS, Himmelfarb J. Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA 2011; 305: 2532-9.
[2] Zhang L, Long J, Jiang W et al. Trends in chronic kidney disease in China. N Engl J Med 2016; 375: 905-6.
[3] Wang JL, Han QQ, Zhao LJ, et al. Identification of clinical predictors of diabetic nephropathy and non-diabetic renal disease in Chinese patients with type 2 diabetes, with reference to disease course and outcome. Acta Diabetol 2019; 56: 939-46.
[4] Chang TI, Park JT, Kim JK, et al. Renal outcomes in patients with type 2 diabetes with or without coexisting non-diabetic renal disease. Diabetes Res Clin Pract 2011; 92: 198-204.
[5] Fiorentino M, Bolignano D, Tesar V, et al. Renal biopsy in patients with diabetes: a pooled Meta-analysis of 48 studies. Nephrol Dial Transplant 2017; 32: 97-110.
[6] Khan MZ, Hussain M, Khan AA, et al. Frequency of non-diabetic renal disease in type 2 diabetes mellitus patients undergoing renal biopsy. J Ayub Med Coll Abbottabad 2021; 33: S757-62.
[7] Stevens PE and Levin A. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med 2013; 158: 825-30.
[8] Diabetes Professional Committee of the Society of Internal Medicine of the Chinese Society of traditional Chinese Medicine. Criteria for TCM staging, syndrome differentiation and curative effect evaluation of diabetes mellitus (diabetes mellitus). Zhong Guo Yi Yao Xue Bao 1993; 3: 54-6.
[9] Zheng XY. Guiding principles for clinical research of new Traditional Chinese Medicine. Beijing: China Medical Science and Technology Press, 2002; 233-7.
[10] Chinese Society of Traditional Chinese Medicine. Guidelines for Traditional Chinese Medicine prevention and treatment of Diabetes. Zhong Guo Zhong Yi Yao Xian Dai Yuan Cheng Jiao Yu 2011; 4: 151-3.
[11] Tervaert TW, Mooyaart AL, Amann K, Cohen AH, Terence H, Cook HT. Pathologic classification of diabetic nephropathy. J Am Soc Nephrol 2010; 21: 556-63.
[12] Garcia-Martin F, Gonzalez Monte E, Hernandez Martinez E, Bada Boch T, Bustamante Jiménez NE, Praga Terente M. When to perform renal biopsy in patients with type 2 diabetes mellitus? Predictive model of non-diabetic renal disease. Nefrologia 2020; 40: 180-9.
[13] Zhao LJ, Han QQ, Zhou L, et al. Addition of glomerular lesion severity improves the value of anemia status for the prediction of renal outcomes in Chinese patients with type 2 diabetes. Ren Fail 2022; 44: 346-57.
[14] Liu MY, Xie YS, Dong ZY, et al. The role of hemoglobin in differentiating diabetic nephropathy from non-diabetic renal disease. Chin J Kidney Dis Invest (Electronic Edition) 2018; 7: 271-6.
[15] United Kingdom Prospective Diabetes Study UKPDS. 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ 1995; 310: 83-8.
[16] Jing N, Pan MX, Song Y, et al. Renal outcomes and prognostic factors in patients with type-2 diabetes and chronic kidney disease confirmed by renal biopsy. Ther Adv Chronic Dis 2021; 12: 20406223211052388.
[17] Zhuo L, Ren WW, Li WG, Zou GM, Lu JH. Evaluation of renal biopsies in type 2 diabetic patients with kidney disease: a clinicopathological study of 216 cases. Int Urol Nephrol 2013; 45: 173-9.
[18] He F, Xia X, Wu XF, Yu XQ, Huang FX. Diabetic retinopathy in predicting diabetic nephropathy in patients with type 2 diabetes and renal disease: a Meta-analysis. Diabetologia 2013; 56: 457-66.
[19] Liu XL, Liu BL. Discussion on the etiology, symptoms, treatment principles and treatment of blood deficiency syndrome based on the ancient literature of Traditional Chinese Medicine. Beijing Zhong Yi Yao 2020; 39: 262-5.
[20] Yao ML, Yang XM, Li CD, Gan HJ, Huang WJ, Wei LY. Analysis of expert questionnaire in the third round of self-rating scale of Qi-stagnation syndrome. Anhui Zhong Yi Yao Da Xue Xue Bao 2015; 34: 9-12.
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