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Journal of Traditional Chinese Medicine >

2022 , Vol. 42 >Issue 6: 1023 - 1028

DOI: https://doi.org/10.19852/j.cnki.jtcm.2022.06.011

Reviews

Therapeutic mechanisms of integrated traditional Chinese and conventional medicine underlying its treatment of precancerous lesions of gastric cancer

  • Qing XU ,
  • Yang WANG ,
  • Zhongyu LI ,
  • Jiaxing YAN ,
  • Yingpan ZHAO ,
  • Ping WANG ,
  • Yandong WEN
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  • 1 Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China
    2 Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China
Prof. WEN Yandong, Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China. wen6120@126.com,Telephone: +86-10-62886842

Received date: 2021-10-11

  Accepted date: 2022-01-23

  Online published: 2022-06-11

Supported by

National Key Technology R&D Program during the 13th Five-Year Plan Period Evidence-based evaluation and efficacy mechanism of Jianpi-Huoxue principle in the treatment of gastric precancerous lesions(2017YFC1700601);Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences: Screening of miRNAs in different pathological stages of gastric mucosal “inflammation-cancer” transformation and its correlation with symptom patterns(CI2021A01005)

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Abstract

China has a high incidence of gastric cancer. Secondary prevention of gastric cancer is a major public health problem that must be solved urgently. Modern medicine focuses on the pathogenesis of precancerous lesions of gastric cancer (PLGC), and it has been found that there are a variety of abnormal gene expression patterns in PLGC. This study summarizes recent advances in our understanding of the therapeutic mechanisms of PLGC from various clinical studies; this will provide a reference for studying the therapeutic mechanisms of Traditional Chinese Medicine in the treatment of PLGC from the combined points of view of Traditional Chinese and Conventional medicine.

Key words： stomach neoplasms; precancerous lesions; mechanisms; integrative medicine; review

Cite this article

Qing XU , Yang WANG , Zhongyu LI , Jiaxing YAN , Yingpan ZHAO , Ping WANG , Yandong WEN . Therapeutic mechanisms of integrated traditional Chinese and conventional medicine underlying its treatment of precancerous lesions of gastric cancer[J]. Journal of Traditional Chinese Medicine, 2022 , 42(6) : 1023 -1028 . DOI: 10.19852/j.cnki.jtcm.2022.06.011

References

[1] Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71: 209-49.
[2] Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin 2016; 66: 115-32.
[3] Correa P, Haenszel W, Cuello C, Tannenbaum S, Archer M. A model for gastric cancer epidemiology. Lancet 1975; 306: 58-60.
[4] Cai Q, Zhu C, Yuan Y, et al. Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: a nationwide multicentre study. Gut 2019; 68: 1576-87.
[5] Chen X, Zhang ZQ, Wan J, Zhang JP, Wang YH, Fu YH. Follow-up study of gastric mucosal epithelial cell dysplasia. Zhong Hua Xiao Hua Nei Jing Za Zhi 2003; 20: 318-20.
[6] Jiang N, Huang X, Fan YH, Lu B. Systematic evaluation of the efficacy of integrated Traditional Chinese and Western Medicine in the treatment of gastric precancerous lesions. Zhong Hua Zhong Yi Yao Xue Kan 2015; 33: 149-54.
[7] Wang X, Wei MX. Talking about the integration of Traditional Chinese and Western Medicine from the treatment of gastric precancerous lesions. Liaoning Zhong Yi Yao Da Xue Xue Bao 2013; 15: 91-3.
[8] Aradhya S, Nelson DL. NF-kappaB signaling and human disease. Curr Opin Genet Dev 2001; 11: 300-06.
[9] Jin XY. Expression of GRP78, Caspase-4, NF-κB/p65, and Bcl-2 in gastric cancer and precancerous lesions. Yangzhou: Yangzhou University, 2014: 23.
[10] Cui T, Liu Y, Zhu ZA, Feng SJ, Li FZ. The expression and significance of NF-κB, Bcl-2, Bax in gastric dysplasia and gastric cancer. Shan Dong Da Xue Xue Bao (Yi Xue Ban) 2006; 44: 689-93.
[11] Xiao GC. Study on the effect of Jianpiheweifang on gastric precancerous lesions based on NF-κB/Bcl-2 cell apoptosis pathway. Sichuan Zhong Yi 2017; 35: 94-6.
[12] Pang LW. The study of clinical effect observition of Jianpi Xiaodu drink based on the hypothesis of “spleen deficiency and toxic damage to stomach collaterals” on precancerous lesions of CAG and its effect on expression of Bcl-2, Bax. Shandong: Shandong TCM University, 2018: 31-3.
[13] Warth A, Cortis J, Soltermann A, et al. Tumour cell proliferation (Ki-67) in non-small cell lung cancer: a critical reappraisal of its prognostic role. Br J Cancer 2014; 111: 1222-9.
[14] Li ZQ, Huang XZ, Li ZF, et al. Expression and significance of p16Nk4 and Ki67 in gastric cancer and precancerous lesions. Xian Dai Zhong Liu Yi Xue 2018; 26: 2223-7.
[15] Yu YQ, Wang JN, Zhai QZ, et al. Expression and significance of Ki-67, p53, P504s in gastric precancerous lesions and early gastric cancer. Wei Chang Bing Xue 2018; 23: 21-6.
[16] Liu ZY, Zhang WF. The effect of Traditional Chinese medicine on the expression of Bcl-2, Ki-67, and APC in gastric precancerous lesions. Shi Jie Zui Xin Yi Xue Xin Xi Wen Zhai 2018; 18: 163+7.
[17] Wang XJ, Liu HY, Li Y, et al. Treatment of 59 cases of epigastric pain of precancerous lesions with Qi deficiency and blood stasis by Wei Zhuanan Decoction. Fujian Zhong Yi Yao 2017; 48: 1-2.
[18] Liang GY, Ding Y, Xi YJ, Liu JF, Cai HB. Discussion on the progress of Chinese medicine treatment of gastric precancerous lesions based on gene regulation. Hainan Yi Xue Yuan Xue Bao 2021; 27: 1197-200.
[19] Chen WZ, Yan ZP, Liu YM, et al. Expression and significance of GSK-3β, β-catenin, and Cyclin D1 in gastric tissue of rats with precancerous lesions of the stomach. Liaoning Zhong Yi Za Zhi 2018; 45: 1278-81.
[20] Yamashita K, Sakuramoto S, Watanabe M. Genomic and epigenetic profiles of gastric cancer: potential diagnostic and therapeutic applications. Surg Today 2011; 41: 24-38.
[21] Zhu YX, Zhao MX, Jiang DG, et al. Expression of tumor suppressor gene p53, apoptosis suppressor gene Bcl-2, and pro-apoptotic gene Bax in gastric cancer and precancerous lesions. Wei Chang Bing Xue He Gan Bing Xue Za Zhi 2016; 25: 1040-3.
[22] Gao H, Zhang Y, Zhou J, et al. The relationship between p16 gene methylation and malignant transformation of gastric mucosal dysplasia. Zhong Hua Zhong Liu Fang Zhi Za Zhi 2017; 24: 431-6.
[23] Zhang Y. The expression of tumor suppressor gene protein Runx3 in gastric cancer and adjacent tissues and its correlation with p21. Lanzhou: Lanzhou University, 2007: 11-4.
[24] Luo W, Zhou J, Xia H, et al. Expression of PTEN protein in gastric cancer and its clinicopathological significance. Zhong Nan Yi Xue Ke Xue Za Zhi 2017; 45: 109-12.
[25] Gao Q, Li JC. The expression of PTEN and ERK2 in the occurrence and development of gastric cancer. Zhong Guo Wu Zhen Xue Za Zhi, 2005; 5: 813-5.
[26] Wang LD, Liu XY, Mao LF, et al. Expression of PTEN gene in different TCM syndrome types of gastric precancerous lesions. Zhong Yi Lin Chuan Yan Jiu 2017; 9: 5-8.
[27] Liang GY, Li L, Guo LY, et al. The effect of Xinwei granule on the expression of Bcl-2, C-myc, P53 and P16 protein in patients with gastric precancerous lesions. Zhong Guo Zhong Xi Yi Jie He Xiao Hua Za Zhi 2017; 25: 419-21.
[28] Zhang ML, Shi ZH, Liu Y, Zhao WZY. Research progress of gastric precancerous lesion signaling pathway and related Chinese medicine treatment. Tianjin Zhong Yi Yao 2020; 37: 227-34.
[29] Zhao XZ, Hu JC, Qing LL. Correlation between the microstructure of gastric mucosa with intestinal metaplasia and the subtype of intestinal metaplasia and abnormal expression of CDX2, MUC2, MUC5AC. Hainan Yi Xue 2016; 27: 79-81.
[30] Zhang YJ. The expression and significance of MUC2, MUC5AC, MUC6 and p53 in gastric cancer and preinvasive lesions. Beijing: Capital Medical University, 2017: 13-18.
[31] Rao J, Yang XJ, Fan DM, et al. Effect the treatment of Jianpi Qingre Huayu decoction with gastric precancerous lesions and its influence on Mucin 5 AC protein expression. Zhong Guo Shi Yan Fang Ji Xue Za Zhi 2014; 20: 183-7.
[32] Yan D, Yang Y, Li CS. Effect of Yangyin Qingre Tongluo formula combined with Western medicine on serum tumor markers and MUC5AC, endothelin levels in patients with gastric precancerous lesions. Xian Dai Zhong Xi Yi Jie He Za Zhi 2016; 25: 3718-20.
[33] Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001; 357: 539-45.
[34] Qi XZ, Ma ZH, Li ZQ. Research progress of Traditional Chinese Medicine in improving inflammatory factors in gastric precancerous lesions. Shanxi Zhong Yi 2019; 40: 976-8.
[35] Liu ZW, Li C, Liu Q, et al. The effect of laparoscopic radical gastric cancer resection on gastric cancer and its effect on patients' serum TNF-α and IL-1β levels. Xian Dai Sheng Wu Yi Xue Jin Zhan 2017; 17: 3502-5.
[36] Liu Y, Wu JM, Tao LH, et al. Serum IL-18 and IL-1β levels in patients with gastric cancer and their clinical significance. Wei Chang Bing Xue 2016; 21: 724-8.
[37] Chen HW, Wang J. Research progress on the role and mechanism of IL-8/R in gastric cancer. Mian Yi Xue Za Zhi 2013; 29: 447-51.
[38] Syu L-J, El-Zaatari M, Eaton KA, et al. Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia. Am J Pathol 2012; 181: 2114-25.
[39] Wu DD, Dong WG. The role of TNF-α in the occurrence and development of gastric cancer and the progress of treatment. Yi Nan Bing Za Zhi 2018; 17: 428-32.
[40] Gurzu S, Orlowska J, Sugimura H, et al. Immunohistochemical features and staging of early gastric cancer. Arch Med Sci 2017; 13: 1373-82.
[41] Pinto MP, Owen GI, Retamal I, Garrido M. Angiogenesis inhibitors in early development for gastric cancer. Expert opinion on investigational drugs 2017; 26: 1007-17.
[42] Zhou L, Deng L Y, Guo L F, et al. The effect of Jianwei Xiaopi Decoction on the outcome of patients with gastric precancerous lesions and its mechanism. Zhong Guo Shi Yan Fang Ji Xue Za Zhi 2018; 24: 206-11.
[43] Chen X, Sun MY, Liu NN, et al. Research progress on the molecular genetics of gastric precancerous lesions. Zhong Guo Yi Kan 2018; 53: 477-81.
[44] Zeng K. Research progress of exosome-derived miRNA in gastrointestinal tumors. Yi Xue Yan Jiu Sheng Xue Bao 2020; 33: 108-12.
[45] Wang XW, Wu Y, Wang D, Qin ZF. MicroRNA network analysis identifies key microRNAs and genes associated with precancerous lesions of gastric cancer. Genet Mol Res 2014; 13: 8695-703.
[46] Zhang J, Song Y, Zhang C, et al. Circulating MiR-16-5p and MiR-19b-3p as two novel potential biomarkers to indicate progression of gastric cancer. Theranostics 2015; 5: 733-45.
[47] Liu WS, Guo XN, Yang Y, et al. Correlation analysis between pathological types and clinical prognosis of gastric cancer and serum miR-133a and DKK-1. Shanxi Yi Xue Za Zhi 2020; 49: 751-4.
[48] Wu JH, Pu XY, Zhang X, et al. Expression of miR-421 in gastric cancer and its effect on the proliferation of BGC-823 cells. Shi Yong Zhong Liu Za Zhi 2014; 29: 432-5.
[49] Zhou C, Hou L, Meng XJ. Research progress of gastric juice and gastric diseases. Wei Chang Bing Xue 2020; 25: 234-7.
[50] Feng XK, Lin ZY, Liu X, Geng L, Wei MX, Wang P. The effect of Huatan Xiaoyu Decoction in reversing gastric precancerous lesions and its influence on gastric juice exosomal miRNA expression. Xian Dai Zhong Xi Yi Jie He Za Zhi 2021; 30: 936-9.
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