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Journal of Traditional Chinese Medicine >

2022 , Vol. 42 >Issue 5: 758 - 763

DOI: https://doi.org/10.19852/j.cnki.jtcm.20220707.002

Research Articles

Efficacy of Qiancao (Radix Rubiae Cordifoliae) and Haipiaoxiao (Endoconcha Sepiellae), a traditional Chinese herb pair, on abnormal uterine bleeding in rats with incomplete abortion

  • Tiantian ZHANG ,
  • Guowen LI ,
  • Zhifeng CHU ,
  • Jie LI ,
  • Lijun YU ,
  • Yuan GAO ,
  • Huifeng WANG
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  • 1 Department of Pharmacy, Shanghai Songjiang Fangta Hospital of TCM, Shanghai 201600, China
    2 Department of Pharmacy, Shanghai TCM-Integrated Hospital, Shanghai 200080, China
    3 Department of Traditional Chinese Medicine, Shanghai Songjiang Fangta Hospital of TCM, Shanghai 201600, China
WANG Huifeng, Department of Pharmacy, Shanghai Songjiang Fangta Hospital of TCM, Shanghai 201600, China. michelle2630@163.com Telephone: +86-18918287226

Received date: 2021-05-12

  Accepted date: 2021-08-02

  Online published: 2022-07-07

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Abstract

OBJECTIVE: To investigate the most effective weight ratio of Qiancao (Radix Rubiae Cordifoliae) and Haipiaoxiao (Endoconcha Sepiellae) used to produce decoction for the treatment of abnormal uterine bleeding (AUB) in rats with incomplete abortion, and to study the possible mechanism.

METHODS: The models of AUB were established by incomplete drug abortion with mifepristone and misoprostol in pregnant rats. The therapeutic effects of decoctions made by eight different weight ratios of Qiancao (Radix Rubiae Cordifoliae) and Haipiaoxiao (Endoconcha Sepiellae) were observed.

RESULTS: Statistical analysis revealed that the most effective weight ratio of Qiancao (Radix Rubiae Cordifoliae) and Haipiaoxiao (Endoconcha Sepiellae) to treat AUB in this study was 2∶1.

CONCLUSION: The insights gained from this study would improve understanding of the mechanisms involved in the effect of Qiancao (Radix Rubiae Cordifoliae) and Haipiaoxiao (Endoconcha Sepiellae) on AUB.

Key words： uterine hemorrhage; Qiancao (Radix Rubiae Cordifoliae); Haipiaoxiao (Endoconcha Sepiellae); herb pair; weight ratio

Cite this article

Tiantian ZHANG , Guowen LI , Zhifeng CHU , Jie LI , Lijun YU , Yuan GAO , Huifeng WANG . Efficacy of Qiancao (Radix Rubiae Cordifoliae) and Haipiaoxiao (Endoconcha Sepiellae), a traditional Chinese herb pair, on abnormal uterine bleeding in rats with incomplete abortion[J]. Journal of Traditional Chinese Medicine, 2022 , 42(5) : 758 -763 . DOI: 10.19852/j.cnki.jtcm.20220707.002

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