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Journal of Traditional Chinese Medicine >

2022 , Vol. 42 >Issue 4: 641 - 651

DOI: https://doi.org/10.19852/j.cnki.jtcm.2022.04.007

Reviews

Herbal anthelmintic agents: a narrative review

  • Adak Manjusa ,
  • Kumar Pradeep
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  • Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Ghudda, Bathinda, Punjab 151401, India
Pradeep Kumar, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Ghudda, Bathinda, Punjab 151401, India. pradeepyadav27@gmail.com, Telephone: 9813774553

Received date: 2021-10-16

  Accepted date: 2022-01-05

  Online published: 2022-07-12

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Abstract

Helminths or Parasitic worms of humans may cause chronic and sometimes deadly diseases, considered as neglected tropical diseases (NTDs) that infect around two billion people worldwide. Plants have been used as anthelmintics from ancient times. This review is a compilation of plants as source of anthelmintic drug. All information presented in this review article regarding the anthelmintic activities of plants from 2005 and has been acquired by approaching various electronic databases, including Scopus, Google scholar, Web of science and PubMed. Literature was surveyed for anthelmintic activity of plants which showed that secondary metabolites of plants like terpenes, glycosides, saponins, flavonoids, tannins and alkaloids were having anthelmintic activity. Since this review is a compilation of anthelmintic activity of plants from the year 2005, it will definitely be a fruitful study for researchers working in this field.

Key words： helminths; helminthiasis; anthelmintics; biological products; anthelmintics

Cite this article

Adak Manjusa , Kumar Pradeep . Herbal anthelmintic agents: a narrative review[J]. Journal of Traditional Chinese Medicine, 2022 , 42(4) : 641 -651 . DOI: 10.19852/j.cnki.jtcm.2022.04.007

References

1 Fenwick A. The global burden of neglected tropical diseases. J Public Health 2012; 126: 233-6.
2 Hotez PJ, Bottazzi ME, Strych U. New vaccines for the world's poorest people. Annu Rev Med 2016; 67: 405-17.
3 Knox M, Besier R, Le LJ. Novel approaches to the control of helminth parasites of livestock. Foreword. Vet Parasitol 2012; 186: 1-1.
4 Stepek G, Behnke JM, Buttle DJ, et al. Natural plant cysteine proteinases as anthelmintics? Trends Parasitol 2004; 20: 322-7.
5 Kappus KD, Lundgren Jr RG, Juranek DD, et al. Intestinal parasitism in the United States: Update on a continuing problem. Am J Trop Med Hyg 1994; 50: 705-13.
6 Sharpe C, Thornton DJ, Grencis RK. A sticky end for gastrointestinal helminths; the role of the mucus barrier. Parasite Immunol 2018; 40: e12517.
7 Preston S, Jiao Y, Baell JB, et al. Screening of the ‘Open Scaffolds’ collection from compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes. Int J Parasitol 2017; 7: 286-94.
8 Liu M, Panda SK, Luyten W. Plant-based natural products for the discovery and development of novel anthelmintics against nematodes. Biomolecules 2020; 10: 426.
9 Hu Y, Georghiou SB, Kelleher AJ, et al. Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice. PLoS Negl Trop Dis 2010; 4: e614.
10 Bogitsh BJ, Carter CE, Oeltmann TN. Intestinal Nematodes. In: Human parasitology. 5th ed. Massachusetts: Academic Press, 2019: 277-311.
11 Hotez PJ. Neglected parasitic infections and poverty in the United States. PLoS Negl Trop Dis 2014; 8: e3012.
12 Brooker S, Kabatereine N, Gyapong J, et al. Rapid mapping of schistosomiasis and other neglected tropical diseases in the context of integrated control programmes in Africa. Parasitol 2009; 136: 1707-18.
13 Geary TG, Chibale K, Abegaz B, et al. A new approach for anthelmintic discovery for humans. Trends Parasitol 2012; 28: 176-81.
14 Minciullo P, Cascio A, David A, et al. Anaphylaxis caused by helminths: review of the literature. Eur Rev Med Pharmacol Sci 2012; 16: 1513-8.
15 van Riet E, Hartgers FC, Yazdanbakhsh M. Chronic helminth infections induce immunomodulation: Consequences and mechanisms. J Immunobiol 2007; 212: 475-90.
16 Kaewkes S. Taxonomy and biology of liver flukes. Acta Tropica 2003; 88: 177-86.
17 Tsai IJ, Zarowiecki M, Holroyd N, et al. The genomes of four tapeworm species reveal adaptations to parasitism. Nature 2013; 496: 57-63.
18 Traversa D. Pet roundworms and hookworms: a continuing need for global worming. Parasit Vectors 2012; 5: 91.
19 Bethony J, Brooker S, Albonico M, et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 2006; 367: 1521-32.
20 Sabattani S, Marliani AF, Roncaroli F, et al. Cerebral coenurosis: case illustration. J Neurosurg 2004; 100: 964.
21 Marcial-Rojas RA. Pathology of protozoal and helminthic diseases, with clinical correlation. Baltimore: Williams & Wilkins Co. Edinburgh: Churchill Livingstone; 1971: 698-710.
22 Ohnishi K, Murata M. Single dose treatment with praziquantel for human diphyllobothrium nihonkaiense infections. Trans R Soc Trop Med Hyg 1993; 87: 482-3.
23 Gökçek C, Bayar N, Buharal Z. Total removal of an unruptured orbital hydatid cyst. Can J Ophthalmol 2001; 36: 218-20.
24 Demir K, Karsli A, Kaya T, et al. Cerebral hydatid cysts: CT findings. Neuroradiol J 1991; 33: 22-4.
25 Botterel F, Bourée P. Ocular sparganosis:a case report. J Travel Med 2003; 10: 245-6.
26 Pushker N, Bajaj MS, Betharia SM. Orbital and adnexal cysticercosis. Clin Exp Ophthalmol 2002; 30: 322-33.
27 Hughes A, Biggs B. Parasitic worms of the central nervous system: An Australian perspective. Intern Med J 2002; 32: 541-53.
28 Niu M, Duma R. Meningitis due to protozoa and helminths. Infect Dis Clin North Am 1990; 4: 809-41.
29 Remme J, Boatin B, Boussinesq M. Helminthic diseases:onchocerciasis and loiasis. In: Quah SR, Cockerham WC, editors. International encyclopedia of public health. 2nd ed. DC: Academic Press; 2017: 576-87.
30 Marti H, Haji HJ, Savioli L, et al. A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children. Am J Trop Med Hyg 1996; 55: 477-81.
31 Ament CS, Young LH. Ocular manifestations of helminthic infections: Onchocersiasis, cysticercosis, toxocariasis, and diffuse unilateral subacute neuroretinitis. Int Ophthalmol Clin 2006; 46: 1-10.
32 Grove DI, Mahmoud A, Warren KS. Eosinophils and resistance to Trichinella spiralis. J Exp Med 1977; 145: 755-9.
33 Katz M. Anthelmintics. Drugs 1977; 13: 124-36.
34 De los Reyes-Gavilán CG, Fernández M, Hudson JA, et al. Role of microorganisms present in dairy fermented products in health and disease. BioMed Res Int 2015;
35 Saltveit ME. Fruit and vegetable phytochemicals: chemistry and human health, synthesis and metabolism of phenolic compounds. 2nd ed. Hoboken: John Wiley & Sons, 2017: 115-24.
36 Chanda S, Ramachandra T. A review on some Therapeutic aspects of phytochemicals present in medicinal plants. Int J Pharm Life Sci 2019; 10: 6052-8.
37 Mukherjee N, Mukherjee S, Saini P, et al. Phenolics and Terpenoids; The promising new search for anthelmintics: A critical review. Mini Rev Med Chem 2016; 16: 1415-41.
38 Qi H, Wang W, Dai J, et al. In vitro anthelmintic activity of Zanthoxylum simulans essential oil against Haemonchus contortus. Vet Parasitol 2015; 211: 223-7.
39 Overend W. 9 Glycosides. Carbohydr 2012; 1: 279.
40 Kaingu F, Kibor A, Waihenya R, et al. Efficacy of Aloe secundiflora crude extracts on Ascaridia galli in vitro. Sustain Agric Res 2013; 2: 49-53.
41 Hussein RA, El-Anssary AA. Herbal medicine, plants secondary metabolites. In: the key drivers of the pharmacological actions of medicinal plants. 2018; 11-30.
42 Güçlü-Üstündağ Ö, Mazza G. Saponins: properties, applications and processing. Crit Rev Food Sci Nutr 2007; 47: 231-58.
43 Ali N, Shah SWA, Shah I, et al. Cytotoxic and anthelmintic potential of crude saponins isolated from Achillea Wilhelmsii C. Koch and Teucrium Stocksianum boiss. BMC Compl Alternative Med 2011; 11: 106.
44 Cavalcante GS, de Morais SM, Andre WP, et al. Chemical composition and in vitro activity of Calotropis procera (Ait.) latex on Haemonchus contortus. Vet Parasitol 2016; 226: 22-5.
45 Ohri P, Pannu SK. Effect of phenolic compounds on nematodes. J Nat Appl Sci 2010; 2: 344-50.
46 Symeonidou I, Bonos E, Moustakidis K, et al. Botanicals: a natural approach to control ascaridiosis in poultry. J Hellenic Vet Med Soc 2018; 69: 711-22.
47 Del Carmen Acevedo-Ramírez PM, Hallal-Calleros C, Flores-Pérez I, et al. Anthelmintic effect and tissue alterations induced in vitro by hydrolysable tannins on the adult stage of the gastrointestinal nematode Haemonchus contortus. Vet Parasitol 2019; 266: 1-6.
48 Badarina I, Putranto HD, Sulistyowati E. In vitro anthelmintic activity of the extract of coffee husk fermented with Pleurotus ostreatus for Ascaridia galli. Anim Prod Sci 2017; 19: 55-60.
49 Huang T, Jander G, de Vos M. Non-protein amino acids in plant defense against insect herbivores: representative cases and opportunities for further functional analysis. Phytochemistry 2011; 72: 1531-7.
50 Swargiary A, Roy B. In vitro anthelmintic efficacy of Alpinia nigra and its bioactive compound, astragalin against Fasciolopsis buski. Int J Pharm Pharm Sci 2015; 7: 30-5.
51 Lei J, Leser M, Enan E. Nematicidal activity of two monoterpenoids and SER-2 tyramine receptor of Caenorhabditis elegans. Biochem Pharmacol 2010; 79: 1062-71.
52 Vildina JD, Kalmobe J, Djafsia B, et al. Anti-onchocerca and anti-caenorhabditis activity of a hydro-alcoholic extract from the fruits of Acacia nilotica and some proanthocyanidin derivatives. Molecules 2017; 22: 748.
53 Ndjonka D, Abladam E, Djafsia B, et al. Anthelmintic activity of phenolic acids from the axlewood tree Anogeissus leiocarpus on the filarial nematode Onchocerca ochengi and drug-resistant strains of the free-living nematode Caenorhabditis elegans. J Helminthol 2014; 88: 481-8.
54 Pereira I, Severino P, Santos AC, et al. Linalool bioactive properties and potential applicability in drug delivery systems. Colloids Surf B Biointerfaces 2018; 171: 566-78.
55 Burg RW, Miller BM, Baker EE, et al. Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. Antimicrob Agents Chemother 1979; 15: 361-7.
56 Yakoot M. A short review of the anthelmintic role of Mirazid. Arq Gastroenterol 2010; 47: 393-4.
57 Basyoni MM, El-Sabaa AAA. Therapeutic potential of myrrh and ivermectin against experimental Trichinella spiralis infection in mice. Korean J Parasitol 2013; 51: 297-304.
58 Asha M, Prashanth D, Murali B, et al. Anthelmintic activity of essential oil of Ocimum sanctum and eugenol. Fitoterapia 2001; 72: 669-70.
59 Kirtiman S. Comparative study of Withania somnifera and Ocimum sanctum for anthelmintic activity. ISCA J Bio Sci 2012; 1: 74-6.
60 Cala A, Chagas A, Oliveira M, et al. In vitro anthelmintic effect of Melia azedarach L. and Trichilia claussenii C. against sheep gastrointestinal nematodes. Exp Parasitol 2012; 130: 98-102.
61 Cala AC, Ferreira JF, Chagas ACS, et al. Anthelmintic activity of Artemisia annua L. extracts in vitro and the effect of an aqueous extract and artemisinin in sheep naturally infected with gastrointestinal nematodes. Parasitol Res 2014; 113: 2345-53.
62 Kanthal LK, Mondal P, De S, et al. Evaluation of anthelmintic activity of carica papaya latex using Pheritima posthuma. Int J Life Sci Pharma Res 2012; 2: 10-2.
63 Selvaraju A, Dhanraj S. Phytochemical analysis and anthelmintic potential of Nigella sativa against the trematode, Cotylophoron cotylophorum. J Pharmacogn Phytochem 2019; 8: 3161-6.
64 Tandon V, Das B. In vitro testing of anthelmintic efficacy of Flemingia vestita (Fabaceae) on carbohydrate metabolism in Rallietina echinobothrida. Methods 2007; 42: 330-8.
65 Kale AA, Gaikwada SA, Kamble G. In vitro anthelmintic activity of stem bark of Juglans regia L. J Chem Pharm Res 2011; 3: 298-302.
66 Jana GK, Dhanamjayarao M, Vani M. Evaluation of anthelmintic potential of Mimusops elengi Linn (sapotaceae) leaf. J Pharm Res 2010; 3: 2514-5.
67 Ahmed AH, Ejo M, Feyera T, et al. In vitro anthelmintic activity of crude extracts of artemisia herba-alba and Punica granatum against Haemonchus contortus. J Parasitol 2020; 1-7.
68 Ferreira LE, Benincasa BI, Fachin AL, et al. Thymus vulgaris L. essential oil and its main component thymol: anthelmintic effects against Haemonchus contortus from sheep. Vet Parasitol 2016; 228: 70-6.
69 Gundamaraju R. Evaluation of anti-helmintic activity of Ferula foetida “Hing-A natural Indian spice” aqueous extract. Asian Pac J Trop Dis 2013; 3: 189-91.
70 Sen D, Agnihotri RK, Sharma D, et al. In vitro assays on mangifera indica and embelia ribes against Ascaridia galli of poultry. Himachal J Agric Res 2018; 44: 117-24.
71 Hördegen P, Cabaret J, Hertzberg H, et al. In vitro screening of six anthelmintic plant products against larval Haemonchus contortus with a modified methyl-thiazolyl-tetrazolium reduction assay. J Ethnopharmacol 2006; 108: 85-9.
72 Zamilpa A, García-Alanís C, López-Arellano M, et al. In vitro nematicidal effect of Chenopodium ambrosioides and Castela tortuosa n-hexane extracts against Haemonchus contortus (Nematoda) and their anthelmintic effect in gerbils. J Helminthol 2019; 93: 434-9.
73 Ali N, Nabi M, Shoaib M, et al. GC/MS analysis, anti-leishmanial and relaxant activity of essential oil of Chenopodium ambrosioides from Malakand region. Pak J Pharm Sci 2021; 34: 577-83.
74 Rodrigues JGM, Albuquerque PSV, Nascimento JR, et al. The immunomodulatory activity of Chenopodium ambrosioides reduces the parasite burden and hepatic granulomatous inflammation in Schistosoma mansoni-infection. J Ethnopharmacol 2021; 264: 113287.
75 Mali RG, Mehta AA. A review on anthelmintic plants. Nat Prod Rad 2008; 7: 466-75.
76 Boyko OO, Kabar A, Brygadyrenko V. Nematicidal activity of aqueous tinctures of medicinal plants against larvae of the nematodes Strongyloides papillosus and Haemonchus contortus. Biosyst Divers 2020; 28: 119-23.
77 Wang GX, Jiang Dx, Zhou Z, et al. In vivo assessment of anthelmintic efficacy of ginkgolic acids on removal of Ps-eudodactylogyrus in European eel. Aquaculture 2009; 297: 38-43.
78 Bhavare V, Pokharka R. Comparative in vitro anticestodal activity of some medicinal plants from western India. Pharmacologyonline 2010; 3: 142-5.
79 Yadav AK. In vitro anthelmintic assessment of selected phytochemicals against Hymenolepis diminuta, a zoonotic tapeworm. J Parasit Dis 2016; 40: 1082-6.
80 Tangpu V, Temjenmongla K, Yadav AK. Anticestodal activity of Trifolium repens extract. Pharm Biol 2005; 42: 656-8.
81 Gonzales APPF, Santos GG, Tavares-Dias M. Anthelminthic potential of the Ficus insipida latex on monogeneans of Colossoma macropomum (Serrasalmidae), a medicinal plant from the Amazon. Acta Parasitol 2019; 64: 927-31.
82 Chand J, Naaz Y, Nainwal P. In vitro Anthelmintic activity of peel extracts of Cucurbita Maxima. Int Res J Pharm 2019; 10: 22-5.
83 Lateef M, Iqbal Z, Akhtar M, et al. Preliminary screening of Trachyspermum ammi seed for anthelmintic activity in sheep. Trop Anim Health Prod 2006; 38: 491-6.
84 Patil R, Kadam J, Chavan J, et al. Anthelmintic activity of ethanolic bud extract of Syzygium aromaticum against Pheretima posthuma. Weekly Sci Int Res J 2013; 1-5.
85 Dhanraj KM, Veerakumari L. In vitro effect of Syzygium aromaticum on the motility and acetylcholinesterase of Cotylophoron cotylophorum. Ind J Vet Anim Sci Res 2014; 43: 187-94.
86 Cala A, Chagas A, Oliveira M, et al. In vitro anthelmintic effect of Melia azedarach L. and Trichilia claussenii C. against sheep gastrointestinal nematodes. Exp Parasitol 2012; 130: 98-102.
87 Kirtiman S. Comparative study of Withania somnifera and Ocimum sanctum for anthelmintic activity. ISCA J Bio Sci 2012; 1: 74-6.
88 Wangchuk P, Giacomin PR, Pearson MS, et al. Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms. Sci Rep 2016; 6: 32101.
89 Liu M, Panda SK, Luyten W. Plant-based natural products for the discovery and development of novel anthelmintics against nematodes. Biomolecules 2020; 10: 425-6.
90 Soares AM, Lopes SG, et al. Anthelmintic activity of Leucaena leucocephala protein extracts on Haemonchus contortus. Rev Bras Parasitol Vet 2015; 24: 396-401.
91 Kanojiya D, Shanker D, Sudan V, et al. Anthelmintic activity of Ocimum sanctum leaf extract against ovine gastrointestinal nematodes in India. Res Vet Sci 2015; 99: 165-70.
92 Szewczuk VD, Mongelli ER, Pomilio AB. In vitro anthelmintic activity of Melia azedarach naturalized in Argentina. Phytother Res 2006; 20: 993-6.
93 Ameen S, Azeez O, Baba Y, et al. Anthelmintic Potency of Carica papaya seeds against Gastro-intestinal Helminths in Red Sokoto goat. Ceylon J Sci 2018; 47: 137-41.
94 Al-Shaibani I, Phulan M, Arijo A, et al. Anthelmintic activity of Nigella sativa L, seeds on gastrointestinal nematodes of sheep. Pak J Nematol 2008; 26: 207-18.
95 Pal P, Tandon V. Anthelmintic efficacy of Flemingia vestita (Fabaceae) genistein-induced alterations in the ultrastructure of the tegument in the cestode, Raillietina echinobothrida. J Parasit Dis 2010; 22: 104-9.
96 Hayes D, Angove MJ, Tucci J, et al. Walnuts (Juglans regia) chemical composition and research in human health. Crit Rev Food Sci Nutr 2016; 56: 1231-41.
97 Mali RG, Mahajan SG, Mehta AA. In vitro anthelmintic activity of stem bark of Mimusops elengi Linn. PhcogMag 2007; 3: 73-6.
98 Aggarwal R, Kaur K, Suri M, et al. Anthelmintic potential of Calotropis procera, Azadirachta indica and Punica granatum against Gastrothylax indicus. J Parasit Dis 2016; 40: 1230-8.
99 Jalalpure S, Alagawadi K, Mahajanashetti C, et al. In vitro anthelmintic property of various seed oils against Pheritima posthuma. Indian J Pharm Sci 2007; 69: 158.
100 Jabbar A, Zaman MA, Iqbal Z, et al. Anthelmintic activity of Chenopodium album and Caesalpinia crista against trichostrongylid nematodes of sheep. J Ethnopharmacol. 2007; 114: 86-91.
101 Afolayan M, Srivedavyasasri R, Asekun OT, et al. Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria. Med Chem Res 2018; 27: 2325-30.
102 Kiranmayi G, Ravishankar K, Priyabandhavi P. Phytochemical screening and in vitro comparative study of anthelmintic activity of Asparagus racemosus and Cucurbita maxima. J Pharm Res 2012; 5: 1545-7.
103 Tangpu V, Temjenmongla K, Yadav AK. Anticestodal activity of Trifolium repens extract. Pharm Biol 2005; 42: 656-8.
104 Hansson A, Zelada JC, Noriega HP. Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon. J Ethnopharmacol 2005; 98: 251-7.
105 Ayaz E, Gökbulut C, Coşkun H, et al. Evaluation of the anthelmintic activity of pumpkin seeds (Cucurbita maxima) in mice naturally infected with Aspiculuris tetraptera. J Pharmacognosy Phytother 2015; 7: 189-93.
106 Bairwa R, Sodha R, Rajawat B. Trachyspermum ammi. Phcog Rev 2012; 6: 56.
107 Williams AR, Ramsay A, Hansen TV, et al. Anthelmintic activity of trans-cinnamaldehyde and A-and B-type proanthocyanidins derived from cinnamon (Cinnamomum verum). Sci Rep 2015; 5: 14791.
108 Dwivedi G, Bairagi M, Rawal D, et al. Anthelmintic activity of Myristica fragrans (Nutmeg) extract. Res J Pharm Bio Chem Sci 2011; 2: 315-8.
109 Yan H, Haiming S, Cheng G, et al. Chemical constituents of the roots of Inula helenium. Chem Nat Compd 2012; 48: 522-4.
110 Muthee J, Gakuya D, Mbaria J, et al. Ethnobotanical study of anthelmintic and other medicinal plants traditionally used in Loitoktok district of Kenya. J Ethnopharmacol 2011; 135: 15-21.
111 Olounladé P, Azando E, Hounzangbé-Adoté M, et al. In vitro anthelmintic activity of the essential oils of Zanthoxylum zanthoxyloides and Newbouldia laevis against Strongyloides ratti. Parasitol Res 2012; 110: 1427-33.
112 Souza M, Bevilaqua CM, Morais SM, et al. Anthelmintic acetogenin from Annona squamosa L. Seeds. An Acad Bras Ciênc 2008; 80: 271-7.
113 Bhinge SD, Hogade MG, Chavan C, et al. In vitro anthelmintic activity of herb extract of Eclipta prostrate L. against Pheretima posthuma. Asian J Pharm Clin Res 2010; 3: 229-30.
114 Karumari RJ, Sumathi S, Vijayalakshmi K, et al. Anthelmintic efficacy of Sesbania grandiflora leaves and Solanum torvum fruits against the nematode parasite Ascaridia galli. Am J Ethno Med 2014; 1: 326-33.
115 Nirmal S, Gagare P, Dighe S, et al. Anthelmintic activity of some existing polyherbal Ayurvedic formulations. Pharmacologyonline 2008; 3: 76-9.
116 Gajalakshmi S, Vijayalakshmi S, Devi RV. Pharmacological activities of Catharanthus roseus. Int J Pharm Bio Sci 2013; 4: 431-9.
117 Maji AK, Banerji P. Chelidonium majus L.(Greater celandine)-A review on its phytochemical and therapeutic perspectives. Int J Herb Med 2015; 3: 10-27.
118 Kozan E, Küpeli E, Yesilada E. Evaluation of some plants used in Turkish folk medicine against parasitic infections for their in vivo anthelmintic activity. J Ethnopharmacol 2006; 108: 211-6.
119 Barrau E, Fabre N, Fouraste I, et al. Effect of bioactive compounds from Sainfoin (Onobrychis viciifolia Scop.) on the in vitro larval migration of Haemonchus contortus: role of tannins and flavonol glycosides. Parasitology 2005; 131: 531-8.
120 Saddiqe Z, Khalid S, Maimoona A. In vitro antelmintic activity of extracts of Withania Somnifera. J Nat Appl Sci Pakistan 2019; 1: 89-97.
121 Eguale T, Tilahun G, Debella A, et al. In vitro and in vivo anth-elmintic activity of crude extracts of Coriandrum sativum against Haemonchus contortus. J Ethnopharmacol 2007; 110: 428-33.
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