OBJECTIVE: To investigate whether Jieduxiezhuo decoction(JDXZD) can prevent serum uric acid elevations in mice. METHODS: Hyperuricemia in mice was induced by intraperitoneally administering uric acid(250 mg/ kg). Concentrations of uric acid in serum were determined using the uric acid enzyme method. Mice were treated with JDXZD for 4 days before uric acid was administered. RESULTS: After intraperitoneal injection of uric acid, serum uric acid concentrations in mice significantly increased. However, the levels of uric acid in groups pretreated with 16.25 or 4.06 g/kg of JDXZD were significantly lower than those in the model and normal groups. CONCLUSION: Pretreatment with JDXZD slowed increases in serum uric acid levels in mice intraperito-neally administered uric acid.