OBJECTIVE: To retrospectively study the prevalence of fatigue and factors associated with fatigue among acquired immunodeficiency syndrome (AIDS) patients with antiretroviral drug adverse re-ctions. METHODS: Data were collected from case reportforms (CRFs) for a project funded by the 11th National 5-year Special Science and Technology Program on Major Infectious Diseases. Fatigue was defined by patient self-report. The outcomes were the prevalence of fatigue and the potential risk factors of fatigue. Univariate and multivariate logistic regression analyses were conducted to identify the factors associated with fatigue. RESULTS: Among the 228 subjects, the prevalence of fatigue was 86.8%. In univariate analysis, the significant differences in demographic characteristics between patients with and without fatigue were: gender [OR=2.29; 95% CI (1.05-4.98)], education level [OR=0.40; 95% CI (0.18-0.85)], anemia [OR=3.80; 95% CI (1.27-11.31)], time of HIV diagnosis [OR= 0.29; 95% CI (0.13-0.65)], and route of infection [OR= 0.14; 95% CI (0.06-0.32)]. Abnormal taste and rapid pulse were more commonly seen in patients with fatigue (P