OBJECTIVE: To ascertain if it is effective to use extradural injections and manual repositioning of the spine to treat megalgia caused by cervical spondylotic radiculopathy (CSR). METHODS: Patients with megalgia caused by CSR were divided into a treatment group (n=46) treated by extradural injection and manual repositioning of the spine and a control group (n=46) treated by a conventional method. RESULTS: The prevalence of cure was 58.69% and the total prevalence of effective cure in the treatment group was 97.83% and was 23.91% and 78.26%, respectively, in the control group: this difference between the two groups was significant (P< 0.05). CONCLUSION: Treatment of megalgia caused by CSR by extradural injections and manual repositioning of the spine has a good curative effect with rapid analgesia and short therapeutic course.