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Journal of Traditional Chinese Medicine >

2012 , Vol. 32 >Issue 02: 256 - 260

DOI: https://doi.org/10.1016/s0254-6272(13)60021-7

Effects of cold-damp and hot-damp environment on VEGF and IL-1 expression in joint cartilage cells in adjuvant arthritis in rats

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  • Rheumatism Department,General Hospital of Beijing Military Region;TCM Department,The Third Hospital of Beijing University;Wangjing Hospital,China Academy of Chinese Medicinal Sciences;

Accepted date: 2012-06-15

  Online published: 2012-06-15

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Abstract

OBJECTIVE:To study the effects of environmental factors on the degree of injury and expression of vascular endothelial growth factor(VEGF) and interleukin-1(IL-1) in cartilage cells of the joint in a rat model of adjuvant arthritis(AA).METHODS:SD rats aged 10 months were randomly divided into 4 groups that varied by temperature and humidity housing conditions and induction of AA:a control group,a model group,a cold-damp group,and a hot-damp group.All groups except the control group were induced with AA.After 4 w,VEGF and IL-1 expression in cartilage cells of ankle joints of hind limbs were observed.RESULTS:Mean area,optical density,and numbers of VEGF-and IL-1-positive cells in the model group,the cold-damp group,and the hot-damp group were significantly higher than that of the control group(all P

Key words： Adjuvant arthritis model, Vascular endothelial growth factor(VEGF), Interleukin-1(IL-1), Environmental factors

Cite this article

Bai Yun Jing , Jiang De Xun , An Na , Shen Hong Bo , Hu Yin Qi . Effects of cold-damp and hot-damp environment on VEGF and IL-1 expression in joint cartilage cells in adjuvant arthritis in rats[J]. Journal of Traditional Chinese Medicine, 2012 , 32(02) : 256 -260 . DOI: 10.1016/s0254-6272(13)60021-7

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