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Journal of Traditional Chinese Medicine >

2012 , Vol. 32 >Issue 01: 63 - 66

DOI: https://doi.org/10.1016/s0254-6272(12)60033-8

Effects of Compound Danshen tablets(复方丹参片) on spatial cognition and expression of brain β-amyloid precursor protein in a rat model of alzheimer's disease

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  • Modern Chinese Medicine Institute,Guangzhou Baiyunshan Hutchison Whampoa Chinese Medicine Co.Ltd.;

Accepted date: 2012-03-15

  Online published: 2012-03-15

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Abstract

OBJECTIVE:To observe the effects of Compound Danshen Tablets(CDST) on spatial cognition and expression of brain b-amyloid precursor protein(β-APP) in a rat model of Alzheimer's disease.METHODS:The rat model of Alzheimer's disease(AD) was established using D-galactose to cause subacute aging combined with Meynert nucleus damage.Rat behavior was monitored using the Morris water maze,and the expression of β-APP in rat brain tissue was detected via immunohistochemistry.RESULTS:CDST significantly improved spatial cognition and decreased β-APP expression in the cortex and hippocampus(P<0.05,P

Key words： Compound DanshenTablets(CDST), Alzheimer's disease, B-amyloid precursor protein

Cite this article

Qin Ren An , Yao Xiao Xuan , Huang Zhu Ying . Effects of Compound Danshen tablets(复方丹参片) on spatial cognition and expression of brain β-amyloid precursor protein in a rat model of alzheimer's disease[J]. Journal of Traditional Chinese Medicine, 2012 , 32(01) : 63 -66 . DOI: 10.1016/s0254-6272(12)60033-8

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