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Journal of Traditional Chinese Medicine >

2022 , Vol. 42 >Issue 3: 332 - 343

DOI: https://doi.org/10.19852/j.cnki.jtcm.2022.03.002

Systematic review

Antiviral Activity of Medicinal Plants against Human Coronavirus: a systematic scoping review of in vitro and in vivo experimentations

  • Namiranian Parva ,
  • Sadatpour Omid ,
  • Azimzadeh Jamalkandi Sadegh ,
  • Hossein Ayati Mohammad ,
  • Karimi Mehrdad
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  • 1 Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
    2 Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    3 Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Mehrdad Karimi MD, Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Sarparast St, Taleghani St, Tehran, 1668753961, Iran. mehrdadkarimi@yahoo.com, Telephone: +98-21-88974535

Received date: 2021-05-16

  Accepted date: 2021-08-16

  Online published: 2022-05-20

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Abstract

OBJECTIVE: To investigate the in vitro and in vivo studies of natural compounds and medicinal plants with anti-coronavirus activity.

METHODS: A systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Animal Research: Reporting of in vivo experiments guidelines to find data for medicinal plants and natural products effective against human coronaviruses in in vitro or in vivo studies. Studies published up to September 6, 2020 were included. Studies (in vitro or in vivo) reporting the effect of medicinal plants and natural products or their derivatives on human coronavirus were included

RESULTS: Promising anti-coronavirus effects are seen with different herbal compounds like some diterpenoids, sesquiterpenoids, and three compounds in tea with 3CLpro inhibiting effect of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV); Hirsutenone, Six cinnamic amides and bavachinin are PLpro inhibitors and Tanshinones are active on both 3CLpro and PLpro. Some flavonoid compounds of Citrus fruits act on Immun-oregulation and target angiotensin-converting enzyme 2 which is used by SARS-COV for entry. Virus helicase is possibly inhibited by two compounds myricetin and scutellarein.

CONCLUSION: This review shows that complementary medicine have the potential for new drug discovery against coronavirus. Further research is needed before definitive conclusions can be made concerning the safety and efficacy of the use of these medicinal plants.

Key words： Coronavirus; medicine,Persian; medicine,Chinese traditional; plants,medicinal; new drug discovery

Cite this article

Namiranian Parva , Sadatpour Omid , Azimzadeh Jamalkandi Sadegh , Hossein Ayati Mohammad , Karimi Mehrdad . Antiviral Activity of Medicinal Plants against Human Coronavirus: a systematic scoping review of in vitro and in vivo experimentations[J]. Journal of Traditional Chinese Medicine, 2022 , 42(3) : 332 -343 . DOI: 10.19852/j.cnki.jtcm.2022.03.002

References

1 Holmes KV. SARS-associated coronavirus. N Engl J Med 2003; 348:1948-51.
2 Ma Z, Li P, Ji Y, Ikram A, Pan Q. Cross-reactivity towards SARS-CoV-2: the potential role of low-pathogenic human coronaviruses. Lancet Microbe 2020; 1:e151.
3 Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020; 395:565-74.
4 Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395:497-506.
5 Fani M, Teimoori A, Ghafari S. Comparison of the COVID-2019 (SARS-CoV-2) pathogenesis with SARS-CoV and MERS-CoV infections. Future Virol 2020; 15:317-23.
6 World Health Organization. WHO Coronavirus (COVID-19) Dashborad, 2020-04-25. cited 2020-07-10. Available from URL: https://covid19.who.int/.
7 Davison EK, Brimble MA. Natural product derived privileged scaffolds in drug discovery. Curr Opin Chem Biol 2019; 52:1-8.
8 Li J, Li SD, Du N. Clinical study on treatment of severe acute respiratory syndrome with integrative Chinese and Western medicine approach. Zhongguo Zhong Xi Yi Jie He Za Zhi 2004; 24:28-31.
9 Liu J, Manheimer E, Shi Y, Gluud C. Chinese herbal medicine for severe acute respiratory syndrome: a systematic review and meta-analysis. J Altern Complement Med 2004; 10:1041-51.
10 Zhang MM, Liu XM, He L. Effect of integrated traditional Chinese and Western medicine on SARS: a review of clinical evidence. World J Gastroenterol 2004; 10:3500-5.
11 Hsu CH, Hwang KC, Chao CL, et al. An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study. Evid Based Complement Alternat Med 2008; 5:355-362.
12 Jiang YY, Wnag RB, Liu JM. Effect of integrative Chinese and western medicine on T-lymphocyte subsets in treating patients with severe acute respiratory syndrome. Zhong Guo Zhong Xi Yi Jie He Za Zhi 2004; 24:514-6.
13 Fuzimoto AD, Isidoro C. The antiviral and the coronavirus-host protein pathways inhibiting properties of herbs and natural compounds-Additional weapons in the fight against the COVID-19 pandemic? J Trad Complement Med 2020; 10:405-19.
14 Jia W, Gao W. Is traditional Chinese medicine useful in the treatment of SARS? Phytother Res 2003; 17:840-1.
15 Chen Y, Guo JJ, Healy DP, Zhan S. Effect of integrated traditional Chinese medicine and western medicine on the treatment of severe acute respiratory syndrome: A meta-analysis. Pharm Pract (Granada) 2007; 5:1-9.
16 Zhang DH, Wu KL, Zhang X, Deng SQ, Peng B. In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus. J Integr Med 2020; 18:152-8.
17 Lin LT, Hsu WC, Lin CC. Antiviral natural products and herbal medicines. J Tradit Complement Med 2014; 4:24-35.
18 Xu K, Cai H, Shen Y, et al. [Management of corona virus disease-19 (COVID-19): the Zhejiang experience]. Zhejiang Da Xue Xue Bao Yi Xue Ban 2020; 49:147-57.
19 Cui H-T, Li Y-T, Guo L-Y, et al. Traditional Chinese medicine for treatment of coronavirus disease 2019: a review. Traditional Medicine Research 2020; 5(2):65-73.
20 Zhu RF, Gao Rl, Robert SH, Gao Jp, Yang SG, Zhu C. Systematic review of the registered clinical trials of coronavirus diseases 2019 (COVID-19). medRxiv 2020.
21 Xiao XH. Treatment and Prevention of Traditional Chinese Medicines (TCMs) on COVID-19 Infection, 2020-03-24, cited 2020-06-24. Available from URL: https://clinicaltrials.gov/show/NCT04251871.
22 Treatment and Prevention of Traditional Chinese Medicines (TCMs) on 2019-nCoV Infection, 2020-04-11, cited 2020-06-19. Available from URL: https://www.cochranelibrary.com/central/doi/10.1002/central/CN02079983/full?highlightAbstract=sars%7Csar%7Cherb%7Cherbs.
23 Luo H, Tang Ql, Shang YX, et al. Can Chinese medicine be used for prevention of corona virus disease 2019 (COVID-19)? A review of historical classics, research evidence and current prevention programs. Chin J Integr Med 2020; 26:243-50.
24 Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. from 1 November 2002 to 31 July 2003. 2003-12-31. Available from URL: https://www.who.int/publications/m/item/summary-of-probable-sars-cases-with-onset-of-illness-from-1-november-2002-to-31-july-2003.
25 Xiao S, Tian Z, Wang Y, Si L, Zhang L, Zhou D. Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives. Med Res Rev 2018; 38(3):951-76.
26 Zhang T, He Y, Xu W, Ma A, Yang Y, Xu KF. Clinical trials for the treatment of Coronavirus disease 2019 (COVID-19): A rapid response to urgent need. Sci China Life Sci 2020; 63:774-6.
27 Wu C, Liu Y, Yang Y, et al. Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods. Acta Pharm Sin B 2020; 10:766-88.
28 Qama MT, Alqahtani SM, Alamri MA, Chen LL. Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants. J Pharmaceutical Analysis 2020; 10:313-9.
29 Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020; 181:271-280 e278.
30 Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003; 426:450-4.
31 Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004; 203:631-37.
32 Ho TY, Wu SL, Chen JC, Li CC, Hsiang CY. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res 2007; 74:92-101.
33 Yi L, Li Z, Yuan K, et al. Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. J Virol 2004; 78:11334-9.
34 Zumla A, Chan JF, Azhar EI, Hui DS, Yuen K-Y. Coronaviruses—drug discovery and therapeutic options. Nature reviews Drug discovery 2016; 15:327.
35 Li G, De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nature Reviews Drug Discovery 2020; 19:149-51.
36 Millet JK, Séron K, Labitt RN, et al. Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin. Antiviral Res 2016; 133:1-8.
37 Ashour ML, Wink M. Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action. J Pharm Pharmacol 2011; 63:305-21.
38 Cheng PW, Ng LT, Chiang LC, Lin CC. Antiviral effects of saikosaponins on human coronavirus 229E in vitro. Clin Exp Pharmacol Physiol 2006; 33:612-6.
39 Keyaerts E, Vijgen L, Pannecouque C, et al. Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle. Antiviral Res 2007; 75:179-87.
40 van der Meer FJ, de Haan CA, Schuurman NM, et al. The carbohydrate-binding plant lectins and the non-peptidic antibiotic pradimicin A target the glycans of the coronavirus envelope glycoproteins. J Antimicrob Chemother 2007; 60:741-49.
41 Weng JR, Lin CS, Lai HC, et al. Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63. Virus Res 2019; 273:197767.
42 Loizzo MR, Saab AM, Tundis R, et al. Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species. Chem Biodivers 2008; 5:461-70.
43 Caputo L, Nazzaro F, Souza LF, et al. Laurus nobilis: Composition of Essential Oil and Its Biological Activities. Molecules 2017; 22:930.
44 Kim HY, Shin HS, Park H, et al. In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex. J Clin Virol 2008; 41:122-8.
45 Chen CJ, Michaelis M, Hsu HK, et al. Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication. J Ethno-pharmacol 2008; 120:108-11.
46 Wen CC, Shyur LF, Jan JT, et al. Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication. J Tradit Complement Med 2011; 1:41-50.
47 Deng W, Xu Y, Kong Q, et al. Therapeutic efficacy of Pudilan Xiaoyan Oral Liquid (PDL) for COVID-19 in vitro and in vivo. Signal Transduct Target Ther 2020; 5:66.
48 Runfeng L, Yunlong H, Jicheng H, et al. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2). Pharmacol Res 2020; 156:104761.
49 Riviere C, Pawlus AD, Merillon JM. Natural stilbenoids: distribution in the plant kingdom and chemotaxonomic interest in Vitaceae. Nat Prod Rep 2012; 29:1317-33.
50 Lin SC, Ho CT, Chuo WH, Li S, Wang TT, Lin CC. Effective inhibition of MERS-CoV infection by resveratrol. BMC Infect Dis 2017; 17:144.
51 Shun-ya Z, Xiao-yu L, Yun-ling W, Pei-ying Y, E-de Q. Inhibitory effects of three prescriptions of traditional Chinese medicine on SARS-associated coronavirus in vitro. Letters in Biotechnology 2003: 11.
52 Glatthaar-Saalmüller B, Rauchhaus U, Rode S, Haunschild J, Saalmüller A. Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret® against viruses causing respiratory infections. Phytomedicine 2011; 19:1-7.
53 Kumaki Y, Wandersee MK, Smith AJ, et al. Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin. Antiviral Res 2011; 90:22-32.
54 Kim DE, Min JS, Jang MS, et al. Natural bis-benzylisoquinoline alkaloids-tetrandrine, fangchinoline, and cepharanthine, inhibit human coronavirus OC43 infection of MRC-5 human lung cells. Biomolecules 2019; 9:696.
55 Park J-Y, Yuk HJ, Ryu HW, et al. Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors. J Enzyme Inhib Med Chem 2017; 32:504-12.
56 Song YH, Kim DW, Curtis-Long MJ, et al. Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits. Biol Pharm Bull 2014; 37:1021-28.
57 Cho JK, Curtis-Long MJ, Lee KH, et al. Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa. Bioorg Med Chem 2013; 21:3051-7.
58 Park JY, Jeong HJ, Kim JH, et al. Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus. Biol Pharm Bull 2012; 35:2036-42.
59 Tsai YC, Lee CL, Yen HR, et al. Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63. Biomolecules 2020; 10:366.
60 Chen CN, Lin CP, Huang KK, et al. Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3). Evid Based Complement Alternat Med 2005; 2:209-15.
61 Chattopadhyay D, Bhattacharya S. Ethnopharmacology: a new engine for the development of antivirals from naturaceuticals. Handbook of ethnopharmacology, 2008: 129-197.
62 Upadhyay S, Tripathi PK, Singh M, Raghavendhar S, Bhardwaj M, Patel AK. Evaluation of medicinal herbs as a potential therapeutic option against SARS-CoV-2 targeting its main protease. Phytother Res 2020; 34:3411-9.
63 Park JY, Kim JH, Kwon JM, et al. Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava. Bioorg Med Chem 2013; 21:3730-7.
64 Wang YH, Xu KJ, Jiang WS. Experimental and clinical study of shuanghuanglian aerosol in treating acute respiratory tract infection. Zhongguo Zhong Xi Yi Jie He Za Zhi 1995; 15:347-50.
65 Wen CC, Kuo YH, Jan JT, et al. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem 2007; 50:4087-95.
66 Li R, Li Y, Li B, et al. Efficacy and safety of Shufeng Jiedu capsule for coronavirus disease 2019 (COVID-19): A protocol for systematic review and meta-analysis. Medicine (Baltimore) 2020; 99:e21615.
67 Lin CW, Tsai FJ, Tsai CH, et al. Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Res 2005; 68:36-42.
68 Ryu YB, Jeong HJ, Kim JH, et al. Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition. Bioorg Med Chem 2010; 18:7940-7.
69 Lau KM, Lee KM, Koon CM, et al. Immunomodulatory and anti-SARS activities of Houttuynia cordata. J Ethnopharmacol 2008; 118:79-85.
70 Ryu YB, Park SJ, Kim YM, et al. SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii. Bioorg Med Chem Lett 2010; 20:1873-6.
71 Tabin S, Gupta R, Bansal G, Kamili AN. Comparative HPLC analysis of emodin, aloe emodin and rhein in Rheum emodi of wild and in vitro raised plants. J Pharmacognosy Phytochemistry 2016; 5:121.
72 Luo W, Su X, Gong S, et al. Anti-SARS coronavirus 3C-like protease effects of Rheum palmatum L. extracts. Biosci Trends 2009; 3:124-6.
73 Müller C, Schulte FW, Lange-Grünweller K, et al. Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona-and picornaviruses. Antiviral Res 2018; 150:123-9.
74 Yu M-S, Lee J, Lee JM, et al. Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. Bioorg Med Chem Lett 2012; 22:4049-54.
75 Fung KP, Leung PC, Tsui KW, et al. Immunomodulatory activities of the herbal formula Kwan Du Bu Fei Dang in healthy subjects: a randomised, double-blind, placebo-controlled study. Hong Kong Med J 2011; 17 Suppl 2: 41-43.
76 Cheng L, Zheng W, Li M, et al. Citrus Fruits Are Rich in Flavonoids for Immunoregulation and Potential Targeting ACE2. 2020, preprint. Available from URL: https://www.researchgate.net/publication/341281154_Citrus_fruits_are_rich_in_flavonoids_for_immunoregulation_and_potential_targeting_ACE2.
77 Al-Snai A. Iraqi medicinal plants with antiviral effect-a review. IOSR J Pharmacy 2019; 9:57-75.
78 Ulasli M, Gurses SA, Bayraktar R, et al. The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family. Mol Biol Rep 2014; 41:1703-11.
79 Li Y, Li J, Zhong D, et al. Clinical practice guidelines and experts' consensuses of traditional Chinese herbal medicine for novel coronavirus (COVID-19): protocol of a systematic review. Syst Rev 2020; 9:170.
80 Bordoni L, Fedeli D, Nasuti C, et al. Antioxidant and anti-inflammatory properties of nigella sativa oil in human pre-adipocytes. Antioxidants (Basel) 2019; 8:51.
81 Bahrami M, Kamalinejad M, Latifi SA, Seif F, Dadmehr M. Cytokine storm in COVID-19 and parthenolide: preclinical evidence. Phytother Res 2020; 34:2429-30.
82 Magni P, Ruscica M, Dozio E, Rizzi E, Beretta G, Maffei Facino R. Parthenolide inhibits the LPS-induced secretion of IL-6 and TNF-alpha and NF-kappa B nuclear translocation in BV-2 microglia. Phytother Res 2012; 26:1405-9.
83 Wang M, Li Q. Parthenolide could become a promising and stable drug with anti-inflammatory effects. Natural Product Research 2015; 29:1092-101.
84 Okamoto Y, Tanaka M, Fukui T, Masuzawa T. Brazilian propolis inhibits the differentiation of Th17 cells by inhibition of interleukin-6-induced phosphorylation of signal transducer and activator of transcription 3. Immunopharmacol Immunotoxicol 2012; 34:803-9.
85 Berretta AA, Silveira MAD, Condor Capcha JM, De Jong D. Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: Running title: Propolis against SARS-CoV-2 infection and COVID-19. Biomed Pharmacother 2020; 131:110622.
86 Zhuang M, Jiang H, Suzuki Y, et al. Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Res 2009; 82:73-81.
87 Yang CW, Lee YZ, Kang IJ, et al. Identification of phena-nthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus. Antiviral Res 2010; 88:160-8.
88 Naithani R, Mehta RG, Shukla D, Chandersekera SN, Moriarty RM. Antiviral activity of phytochemicals: a current perspective. Dietary components and immune function: Springer; 2010: 421-468.
89 Li SY, Chen C, Zhang HQ, et al. Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antiviral Res 2005; 67:18-23.
90 Schwarz S, Sauter D, Lu W, et al., eds. Coronaviral ion channels as target for Chinese herbal medicine. Forum on Immun-opathological Diseases and Therapeutics; 2012: Begel House Inc.
91 Schwarz S, Sauter D, Wang K, et al. Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus. Planta Med 2014; 80:177-82.
92 Schwarz S, Wang K, Yu W, Sun B, Schwarz W. Emodin inhibits current through SARS-associated coronavirus 3a protein. Antiviral Res 2011; 90:64-9.
93 Dong X, Fu J, Yin X, et al. Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics. Phytother Res 2016; 30:1207-18.
94 Wu CY, Jan JT, Ma SH, et al. Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc Natl Acad Sci U S A 2004; 101:10012-7.
95 Liang PH. Characterization and inhibition of SARS-coronavirus main protease. Curr Top Med Chem 2006; 6:361-76.
96 Jeong CS, Hyun JE, Kim YS, Lee E-S. Ginsenoside RB 1 the anti-ulcer constituent from the head ofPanax ginseng. Arch Pharm Res 2003; 26:906.
97 Wang L, Bao BB, Song GQ, et al. Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main pro-tease: chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study. Eur J Med Chem 2017; 137:450-61.
98 Chang FR, Yen CT, Ei-Shazly M, et al. Anti-human coronavirus (anti-HCoV) triterpenoids from the leaves of Euphorbia neriifolia. Nat Prod Commun 2012; 7:1415-7.
99 Zhang T, Chen D. Anticomplementary principles of a Chinese multiherb remedy for the treatment and prevention of SARS. J Ethnopharmacol 2008; 117:351-61.
100 Signera J, Jonsdottira H, Albrichc W, et al. In vitro antiviral activity of Echinaforce®, an Echinacea purpurea preparation, against common cold coronavirus 229E and highly pathogenic 2 MERS-CoV and SARS-CoV 3. preprint.Available from URL: https://www.researchgate.net/publication/340189213_In_vitro_antiviral_activity_of_EchinaforceR_an_Echinacea_purpurea_preparation_against_common_cold_coronavirus_229E_and_highly_pathogenic_MERS-CoV_and_SARS-CoV.
101 Jan N, John R. Calendula officinalis-an important medicinal plant with potential biological properties. Proceedings of the Indian National Science Academy 2017; 83:769-87.
102 Barnard DL, Kumaki Y. Recent developments in anti-severe acute respiratory syndrome coronavirus chemotherapy. Future Virol 2011; 6:615-31.
103 Hsieh P-W, Chang F-R, Chang C-H, et al. 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents. Bioorg Med Chem Lett 2004; 14:4751-4.
104 Sutton TC, Subbarao K. Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus. Virology 2015; 479-480:247-58.
105 Sutton TC, Subbarao K. Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus. Virology 2015; 479-480:247-58.
106 Zheng N, Xia R, Yang C, et al. Boosted expression of the SARS-CoV nucleocapsid protein in tobacco and its immunogenicity in mice. Vaccine 2009; 27:5001-7.
107 Day CW, Baric R, Cai SX, et al. A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo. Virology 2009; 395:210-22.
108 O'Keefe BR, Giomarelli B, Barnard DL, et al. Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol 2010; 84:2511-21.
109 Pushpa R, Nishant R, Navin K, Pankaj G. Antiviral potential of medicinal plants: an overview. International research journal of pharmacy 2013; 4:8-16.
110 Mukhtar M, Arshad M, Ahmad M, Pomerantz RJ, Wigdahl B, Parveen Z. Antiviral potentials of medicinal plants. Virus Res 2008; 131:111-20.
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