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Journal of Traditional Chinese Medicine >

2022 , Vol. 42 >Issue 2: 264 - 271

DOI: https://doi.org/10.19852/j.cnki.jtcm.2022.02.007

Research Articles

Effectiveness and safety of red yeast rice predominated by monacolin K β-hydroxy acid form for hyperlipidemia treatment and management

  • Benjian CHEN ,
  • Xiaodan HUANG ,
  • Huiting PENG ,
  • Yishi LI ,
  • Yongtao CAO ,
  • Huanlin WU ,
  • Danping XU
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  • 1 Department of Medical, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China
    2 Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
    3 First Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
    4 Department of Mathematical & Computer Sciences, Indiana University of Pennsylvania, Indiana 15705, PA, USA
    5 Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 350122, China
    6 Department of Traditional Chinese Medicine, the Eighth Affiliated Hospital, SunYat-Sen University, Shenzhen 518033, China
XU Danping, Department of Traditional Chinese Medicine, The Eighth Affiliated Hospital, SunYat-Sen University, Shenzhen 518033, China. xudanping@hotmail.com, Telephone: +86-18028680889
CAO Yongtao, Department of Mathematical & Computer Sciences, Indiana University of Pennsylvania, Indiana 15705, PA, USA. ycao@iup.edu;

Received date: 2021-01-21

  Accepted date: 2021-04-22

  Online published: 2022-04-01

Supported by

Guangzhou Science and Technology Plan project(201710010107);Joint Innovation Specific Project in Key areas from Guangdong Branch Institute of China Academy of Chinese Medical Sciences(ZZ0908065);Project of Administration of Traditional Chinese Medicine of Guangdong Province of China(201811389)

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Abstract

OBJECTIVE: To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin K β-hydroxy acid form (MKA), Heye (Folium Nelumbinis), and Cangzhu (Rhizoma Atractylodis Lanceae), compared to lifestyle modifications.

METHODS: Totally 117 subjects with moderate to severe dyslipidemia (according to Chinese guidelines) and low CV risk were randomly assigned into three treatment groups: lifestyle modification (LM), LM plus a low dosage of MKA, LM plus a high dosage of MKA, and treated for 60 d. The primary endpoint was the reduction of low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). Safeties along with Traditional Chinese Medicine Syndromes were assessed through the study.

RESULTS: A low dosage of MKA along with lifestyle modifications caused a significant decrease in LDL-C by 15.6% on average (95% CI, 9.6% to 21%) with, a decrease in TC by 15.3% on average (95% CI, 9.26% to 21.4%), and a decrease in non-HDL-C by 35.4% (95% CI, 25.76% to 41.34%). Weak evidence of a reduction of triglycerides but an increment of HDL-C was observed in patients with severe hyperlipidemia. No severe adverse events occurred during the study.

CONCLUSION: Our results confirm the LDL-C and TC lowering properties of MKA is clinically meaningful. It also produces a significant reduction of non-HDL-C, and slightly effects on TG and HDL-C as well.

Key words： hydroxy acids; lovastatin; hyperlipidemias; cholesterol; cardiovascular prevention; lifestyle modifications; red yeast rice

Cite this article

Benjian CHEN , Xiaodan HUANG , Huiting PENG , Yishi LI , Yongtao CAO , Huanlin WU , Danping XU . Effectiveness and safety of red yeast rice predominated by monacolin K β-hydroxy acid form for hyperlipidemia treatment and management[J]. Journal of Traditional Chinese Medicine, 2022 , 42(2) : 264 -271 . DOI: 10.19852/j.cnki.jtcm.2022.02.007

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