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Journal of Traditional Chinese Medicine >

2014 , Vol. 34 >Issue 03: 317 - 323

DOI: https://doi.org/10.1016/S0254-6272(14)60096-0

Antidepressant effects of Radix et Caulis Acanthopanacis Santicosi extracts on rat models with depression in terms of immobile behavior

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  • Gaire, Department of Pharmacology, College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University Incheon 406-799, Republic of Korea;Functionality Evaluation Research Group,Korea Food Research Institute,Seongnam463-746,Republic of Korea;

Accepted date: 2014-06-15

  Online published: 2022-04-05

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Abstract

OBJECTIVE: To investigate the antidepressant effects of the Radix et Caulis Acanthopanacis Santicosi extracts in response to the tail suspension test(TST)and forced swim test (FST) in rats.METHODS:Male Wistar rats (9-week-old) wereorally administered the Radix et Caulis Acanthopanacis Santicosi extracts(30, 100 and 300 mg/kg) daily for 14 consecutive days. Serum corticosterone level was measured by using commercially available kit.The c-fos immunoreactivity was analyzed using immunohistochemistry methods.RESULTS:The effect of Radix et Caulis Acanthopanacis Santicosi extracts on the immobility time was significantly decreased at high-dose(300 mg/kg)treated group in the TST and FST(47.7%and69.6%,P

Key words： Acanthopanax senticosus, Antidepressive agents, Stress, Behavior

Cite this article

Bhaktaprasad Gaire, Dongwook Lim . Antidepressant effects of Radix et Caulis Acanthopanacis Santicosi extracts on rat models with depression in terms of immobile behavior[J]. Journal of Traditional Chinese Medicine, 2014 , 34(03) : 317 -323 . DOI: 10.1016/S0254-6272(14)60096-0

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