OBJECTIVE: To investigate the effect of Bushen Jianpi formula(BSJP) therapy on survival of the patients with moderate and advanced hepatocellular carcinoma(HCC).METHODS: This was a five-year retrospective study, enrolling 209 adult patients with moderate and advanced HCC patients. Log-rank test, Cox regression analysis and Kaplan-Meier analysis was applied to analyze the data.RESULTS: The outcome of single-factor Kaplan-Meier analysis and Log-rank test showed that stage of Barcelona-clinic liver cancer(BCLC), locoregional therapy and BSJP therapy were three factors that dominantly influenced the survival of moderate and advanced HCC patients(P < 0.05). In Cox multiple-factor regression analysis, lower BCLC staging(RR = 2.016; P = 0.000), locoregional therapy(RR =0.611; P = 0.011) and BSJP therapy(RR = 0.684; P =0.044) were the independent protective factors affecting survival of patients, and BSJP exerted a more significant effect on patients at BCLC-C stage(RR = 0.513; P = 0.002).CONCLUSION: BSJP therapy and locoregional therapy both contributed to prolonged survival for moderate and advanced HCC patients.