OBJECTIVE: To explore the clinical efficacy of the combination of Traditional Chinese and Western Medicines for the treatment of coronavirus disease2019(COVID-19).METHODS: Studies were identified in six popular medical databases.RESULTS: Thirteen studies were included. The results showed that combined treatment with Traditional Chinese and Western Medicines can reduce the probability of progression from mild to severe disease [RR = 0.34, 95% confidence interval(CI)(0.18, 0.65)](P = 0.001) and improve the clinical cure rate [RR = 0.17, 95% CI(0.05, 0.28)](P = 0.004).The use of an integrated treatment strategy shortened the time to the remission of fever [WMD =-1.27, 95% CI(-1.67,-0.92)](P < 0.001) and improved the incidences of the disappearance of fever and fatigue [RR = 1.25, 95% CI(1.06, 1.47)(P =0.007); RR = 1.49, 95% CI(1.13, 1.97)(P = 0.004)].CONCLUSION: A combined treatment strategy is effective for COVID-19.