Journal of Traditional Chinese Medicine ›› 2026, Vol. 46 ›› Issue (2): 447-457.DOI: 10.19852/j.cnki.jtcm.2026.02.017
• Original Articles • Previous Articles Next Articles
Clinical efficacy of abdominal moxibustion at the Zhongji (CV3) in combination with Yiqi Tonglin Yangyin decoction (益气通淋养阴汤) and antibiotics for treating elderly female patients with complicated urinary tract infection
HU Yunhao1, ZHANG Yi1(
), ZHAO Min2, ZHU Danyang1, JIA Xing3, WANG Cunzhou1
- 1
Department of Traditional Chinese Medicine ,Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200336, China
2Department of Traditional Chinese Medicine ,Shanghai Changning District Huayang Street Community Health Service Center Shanghai 200042, China
3Department of Urology Surgery ,Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200336, China
-
Received:2024-12-12Accepted:2025-06-19Online:2026-04-15Published:2026-04-04 -
Contact:Dr. ZHANG Yi, Department of Traditional Chinese Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China. zyyy522@163.com; Tel: +86-13816630909 -
Supported by:Cultivation of Young Traditional Chinese Medicine Practitioners in Changning District(2021CNQNZY005);Observation on the Therapeutic Effect of "Lung-Kidney Co-treatment and Moxibustion-drug Combination" in Preventing the Recurrence of Urinary Tract Infection in Elderly Women(CNKW2022014)
Cite this article
HU Yunhao, ZHANG Yi, ZHAO Min, ZHU Danyang, JIA Xing, WANG Cunzhou. Clinical efficacy of abdominal moxibustion at the Zhongji (CV3) in combination with Yiqi Tonglin Yangyin decoction (益气通淋养阴汤) and antibiotics for treating elderly female patients with complicated urinary tract infection[J]. Journal of Traditional Chinese Medicine, 2026, 46(2): 447-457.
share this article
Table 1 Comparison of clinical efficacy between the two groups [n (%)]
| Group | n | Recovered | Marked response | Moderate response | No response | Total response |
|---|---|---|---|---|---|---|
| Triple | 72 | 38 (52.8) | 22 (30.5) | 10 (13.9) | 2 (2.8) | 70 (95.9) |
| Dual | 72 | 29 (40.3) | 17 (23.6) | 15 (20.8) | 11 (15.3) | 61 (84.7) |
Table 1 Comparison of clinical efficacy between the two groups [n (%)]
| Group | n | Recovered | Marked response | Moderate response | No response | Total response |
|---|---|---|---|---|---|---|
| Triple | 72 | 38 (52.8) | 22 (30.5) | 10 (13.9) | 2 (2.8) | 70 (95.9) |
| Dual | 72 | 29 (40.3) | 17 (23.6) | 15 (20.8) | 11 (15.3) | 61 (84.7) |
Table 2 Comparison of TCM syndrome scores between the two groups ($ \bar{x} \pm s$, points)
| Time | Triple group (n = 72) | Dual group (n = 72) | t value | P value |
|---|---|---|---|---|
| Before treatment | 33.0±3.5 | 33.1±2.6 | 0.216 | 0.415 |
| After treatment | 10.8±2.5 | 15.0±2.7 | 9.435 | <0.001 |
| t value | 43.831 | 40.842 | ||
| P value | <0.001 | <0.001 |
Table 2 Comparison of TCM syndrome scores between the two groups ($ \bar{x} \pm s$, points)
| Time | Triple group (n = 72) | Dual group (n = 72) | t value | P value |
|---|---|---|---|---|
| Before treatment | 33.0±3.5 | 33.1±2.6 | 0.216 | 0.415 |
| After treatment | 10.8±2.5 | 15.0±2.7 | 9.435 | <0.001 |
| t value | 43.831 | 40.842 | ||
| P value | <0.001 | <0.001 |
Table 3 Comparison of immune indicators between the two groups ($ \bar{x} \pm s$, g/L)
| Indicator | Time | Triple group (n = 72) | Dual group (n = 72) | t value | P value |
|---|---|---|---|---|---|
| IgA | Before treatment | 1.9±0.5 | 1.8±0.6 | 0.336 | 0.369 |
| After treatment | 2.8±0.5 | 2.1±0.5 | 7.845 | <0.001 | |
| t value | 10.267 | 2.689 | |||
| P value | <0.001 | 0.005 | |||
| IgM | Before treatment | 8.5±0.9 | 8.4±1.3 | 0.377 | 0.354 |
| After treatment | 14.5±1.5 | 12.0±1.0 | 11.535 | <0.001 | |
| t value | 28.435 | 19.042 | |||
| P value | <0.001 | <0.001 |
Table 3 Comparison of immune indicators between the two groups ($ \bar{x} \pm s$, g/L)
| Indicator | Time | Triple group (n = 72) | Dual group (n = 72) | t value | P value |
|---|---|---|---|---|---|
| IgA | Before treatment | 1.9±0.5 | 1.8±0.6 | 0.336 | 0.369 |
| After treatment | 2.8±0.5 | 2.1±0.5 | 7.845 | <0.001 | |
| t value | 10.267 | 2.689 | |||
| P value | <0.001 | 0.005 | |||
| IgM | Before treatment | 8.5±0.9 | 8.4±1.3 | 0.377 | 0.354 |
| After treatment | 14.5±1.5 | 12.0±1.0 | 11.535 | <0.001 | |
| t value | 28.435 | 19.042 | |||
| P value | <0.001 | <0.001 |
Table 4 Comparison of oxidative stress response indicators between the two groups ($ \bar{x} \pm s$)
| Indicator | Time | Triple group (n = 72) | Dual group (n = 72) | t value | P value |
|---|---|---|---|---|---|
| XOD (mU/L) | Before treatment | 517.2±79.2 | 520.2±75.3 | 0.231 | 0.409 |
| After treatment | 413.8±57.1 | 443.5±61.3 | 3.015 | 0.002 | |
| t value | 8.988 | 6.702 | |||
| P value | <0.001 | <0.001 | |||
| MDA (nmol/mL) | Before treatment | 8.0±0.9 | 8.1±0.8 | 0.207 | 0.419 |
| After treatment | 4.6±0.6 | 6.0±0.7 | 12.954 | <0.001 | |
| t value | 26.868 | 15.848 | |||
| P value | <0.001 | <0.001 | |||
| SOD (U/L) | Before treatment | 77.8±9.7 | 77.5±9.0 | 0.206 | 0.419 |
| After treatment | 91.4±11.3 | 82.3±9.6 | 5.206 | <0.001 | |
| t value | 7.773 | 3.109 | |||
| P value | <0.001 | 0.002 |
Table 4 Comparison of oxidative stress response indicators between the two groups ($ \bar{x} \pm s$)
| Indicator | Time | Triple group (n = 72) | Dual group (n = 72) | t value | P value |
|---|---|---|---|---|---|
| XOD (mU/L) | Before treatment | 517.2±79.2 | 520.2±75.3 | 0.231 | 0.409 |
| After treatment | 413.8±57.1 | 443.5±61.3 | 3.015 | 0.002 | |
| t value | 8.988 | 6.702 | |||
| P value | <0.001 | <0.001 | |||
| MDA (nmol/mL) | Before treatment | 8.0±0.9 | 8.1±0.8 | 0.207 | 0.419 |
| After treatment | 4.6±0.6 | 6.0±0.7 | 12.954 | <0.001 | |
| t value | 26.868 | 15.848 | |||
| P value | <0.001 | <0.001 | |||
| SOD (U/L) | Before treatment | 77.8±9.7 | 77.5±9.0 | 0.206 | 0.419 |
| After treatment | 91.4±11.3 | 82.3±9.6 | 5.206 | <0.001 | |
| t value | 7.773 | 3.109 | |||
| P value | <0.001 | 0.002 |
Table 5 Comparison of recovery time between the two groups ($ \bar{x} \pm s$, days)
| Group | n | Symptoms | Bacteriuria | Urine routine |
|---|---|---|---|---|
| Triple | 72 | 3.9±0.8 | 5.9±2.0 | 7.8±1.8 |
| Dual | 72 | 5.5±1.1 | 8.8±2.6 | 11.9±3.0 |
| t value | - | 10.585 | 7.628 | 10.088 |
| P value | - | <0.001 | <0.001 | <0.001 |
Table 5 Comparison of recovery time between the two groups ($ \bar{x} \pm s$, days)
| Group | n | Symptoms | Bacteriuria | Urine routine |
|---|---|---|---|---|
| Triple | 72 | 3.9±0.8 | 5.9±2.0 | 7.8±1.8 |
| Dual | 72 | 5.5±1.1 | 8.8±2.6 | 11.9±3.0 |
| t value | - | 10.585 | 7.628 | 10.088 |
| P value | - | <0.001 | <0.001 | <0.001 |
| 1. |
Zhang Y, Liu W, Wei G, et al. Bioinspired nanozymes as nanodecoys for urinary tract infection treatment. ACS nano 2024; 18: 9019-30.
DOI URL |
| 2. |
Liu L, Xie K, Yin M, et al. Lower serum levels of vitamin D in adults with urinary tract infection. Infection 2022; 50: 1-8.
DOI |
| 3. |
Carcamo P, Walter E, Frei CR, et al. A comparison of empiric therapy with cefazolin versus ceftriaxone for patients with complicated urinary tract infections in a tertiary care veterans affairs medical center. BMC Infect Dis 2025; 25: 302.
DOI PMID |
| 4. | Wagenlehner F, Caballero VR, Maheshwari V, et al. Efficacy of treatment options for complicated urinary tract infections including acute pyelonephritis: a systematic literature review and network Meta-analysis. J Comp Eff Res 2025; 14: e240214. |
| 5. | Polo JM, Sánchez JLA, Suárez JA, et al. The importance of antimicrobial strategies associated with clinical cure and increased microbiological eradication in patients with complicated urinary tract infections and high risk of relapse. Eur Urol Open Sci 2025; 71: 165-71. |
| 6. |
Spangler FL, Williams C, Aberger ME, et al. Clinical utility of PCR compared to conventional culture and sensitivity testing for management of complicated urinary tract infections in adults: Part II. Evaluation of diagnostic concordance, discordant results, and antimicrobial selection efficacy. Diagn Microbiol Infect Dis 2025; 111: 116646.
DOI URL |
| 7. |
Guerriero S, Matteini E, Gross MM, et al. Complicated urinary tract infections: an update of new and developing antibiotics. Expert Opin Pharmacother 2025; 26: 167-77.
DOI PMID |
| 8. |
Coyle ME, Zhang AL, Xue CC. Authors’ reply re: acupuncture for recurrent urinary tract infection in women: a systematic review and Meta-analysis. BJOG 2020; 127: 1441.
DOI URL |
| 9. |
Qin X, Coyle ME, Zhang AL, et al. Authors’ reply re: acupuncture for recurrent urinary tract infection in women: a systematic review and Meta-analysis. BJOG 2022; 129: 1169-70.
DOI URL |
| 10. |
Nehru VJ, Vandakunnel MJ, Brammacharry U, et al. Risk assessment and transmission of fluoroquinolone resistance in drug-resistant pulmonary tuberculosis: a retrospective genomic epidemiology study. Sci Rep 2024; 14: 19719.
DOI PMID |
| 11. |
Qin X, Coyle ME, Yang L, et al. Acupuncture for recurrent urinary tract infection in women: a systematic review and Meta-analysis. BJOG 2020; 127: 1459-68.
DOI URL |
| 12. |
Guo S, Li X, Li Y, et al. Sitafloxacin pharmacokinetics/ pharmacodynamics against multidrug-resistant bacteria in a dynamic urinary tract infection in vitro model. J Antimicrob Chemother 2022; 78: 141-9.
DOI URL |
| 13. |
Yang W, Liu P, Zheng Y, et al. Transcriptomic analyses and experimental verification reveal potential biomarkers and biological pathways of urinary tract infection. Bioengineered 2021; 12: 8529-39.
DOI PMID |
| 14. |
Li Y, Yin Y, Peng X, et al. A randomized, active-controlled, multicentre clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated or complicated urinary tract infection. Ann Med 2021; 53: 217-26.
DOI PMID |
| 15. |
Gu W, Huang W, Zhang J, et al. Evaluation of urinary inflammatory index in rapid screening of urinary tract infection. Sci Rep 2020; 10: 19306.
DOI PMID |
| 16. | Yang J, Qiu X, Zhou M, et al. Crocetin attenuating urinary tract infection and adherence of uropathogenic E. coli in NRK-52E cells via an inflammatory pathway. J Food Biochem 2021; 45: e13998. |
| 17. |
Li Y, Jiang L, Luo S, et al. Analysis of characteristics, pathogens and drug resistance of urinary tract infection associated with long-term indwelling double-J stent. Infect Drug Resist 2023; 16: 2089-96.
DOI PMID |
| 18. |
Chen K, Zhu Y, Su H, et al. Modified Zhibai Dihuang pill alleviated urinary tract infection induced by extended-spectrum β-lactamase Escherichia coli in rats by regulating biofilm formation. Pharm Biol 2023; 61: 674-82.
DOI URL |
| 19. |
Liu H, Qiu S, Chen M, et al. A clinical prediction tool for extended-spectrum β-lactamase-producing enterobacteriaceae urinary tract infection. BMC Infect Dis 2022; 22: 50.
DOI PMID |
| 20. | Anonymous (Han dynasty). Huang Di Nei Jing. Beijing: People’s Medical Publishing House, 2012: 123. |
| 21. |
Wu R, Teng X, Song Q, et al. Single-cell RNA sequencing reveals sexual diversity in the human bladder and its prospective impacts on bladder cancer and urinary tract infection. BMC Med Genomics 2023; 16: 122.
DOI PMID |
| 22. |
Mo L, Wang J, Qian J, et al. Antibiotic sensitivity of proteus mirabilis urinary tract infection in patients with urinary calculi. Int J Clin Pract 2022; 2022: 7273627.
DOI URL |
| 23. |
Li T, Xu Y, Gong X. Clinical efficacy of Tailin formulation combined with continuous low-dose antimicrobial therapy for recurrent urinary tract infection: study protocol for a multicenter, double-blind, randomized, controlled clinical trial. Trials 2021; 22: 901.
DOI PMID |
| 24. | Hsu YC, Huang HC, Tang KS, et al. Elevated urinary hepcidin level and hypoferremia in infants with febrile urinary tract infection: a prospective cohort study. Children (Basel) 2023; 10: 870. |
| 25. | Chen H, Wang Y, Wang ZM, et al. Effect of moxibustion on ureteral stent-related symptoms after ureteroscopic lithotripsy. Zhong Guo Zhen Jiu 2023; 43: 1251-6. |
| 26. | Lee HY, Bae GE, Lee SD, et al. Moxibustion as an adjunct for lower urinary tract symptoms associated with benign prostate enlargement: a randomized controlled pilot trial. Medicine (Baltimore) 2020; 99: e18918. |
| 27. | Zhang CF, Shen YF, Zhang HY. Efficacy of the herbal cake-separated moxibustion with new-type moxibustion device on urinary retention after spinal cord injury. Zhong Guo Zhen Jiu 2019; 39: 953-6. |
| 28. |
Wang C, Huang W, Gu Y, et al. Effect of urinary tract infection on the risk of prosthetic joint infection: a systematic review and Meta-analysis. Surgeon 2021; 19: 175-82.
DOI URL |
| 29. |
Yuan S, Shi Y, Li M, et al. Trends in incidence of urinary tract infection in mainland China from 1990 to 2019. Int J Gen Med 2021; 14: 1413-20.
DOI PMID |
| 30. | Wang J, Cao Y, Zhang L, et al. Pathogen distribution and risk factors for urinary tract infection in infants and young children with retained double-J catheters. J Int Med Res 2021; 49: 3000605211012379. |
| 31. | Ren C, Li Z, Meng F, et al. Endogenous endophthalmitis caused by urinary tract infection: a case report. Medicine (Baltimore) 2023; 102: e36139. |
| 32. |
Cavalcante RN, Santos ACS, Rodrigues RAS, et al. Wheelchair basketball improves the treatment of urinary tract infection in people with motor disabilities: a clinical trial. Rev Assoc Med Bras (1992) 2022; 68: 559-67.
DOI URL |
| 33. | Ding YE. Ding Ganren and the Shanghai Professional College of Chinese Medicine. Zhong hua Yi Shi Za Zhi 2016; 46: 369-72. |
| [1] | GU Xiangchen, QIU Meisi, XIE Lin, CHEN Min, DENG Yueyi, ZHANG Changming, JIAN Guihua, WANG Chen, WANG Yi. Individualized Traditional Chinese Medicine treatment vs antibiotics for recurrent urinary tract infections: a multicenter, randomized controlled study [J]. Journal of Traditional Chinese Medicine, 2024, 44(3): 524-529. |
| [2] | Fu Mingming, Wang Zhiqian, Liu Yan. Effects of Xinkeshu combined with levosimendan on perioperative heart failure in oldest-old patients with hip fractures [J]. Journal of Traditional Chinese Medicine, 2020, 40(5): 870-874. |
| [3] | Wang Haixia, Mo Shu, Yang Li, Wang Panpan, Sun Kehuan, Xiong Yingquan, Liu Hengrui, Liu Xiaoguang, Wu Zhidi, Ou Ling, Li Xiaoyun, Peng Xunqian, Peng Bojia, He Haibin, Tian Ya, Zhang Ronghua, Zhu Xiaofeng. Effectiveness associated with different therapies for senile osteoporosis: a network Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2020, 40(1): 17-27. |
| [4] | Hou Lili, Xu Lei, Shi Yan, Gu Fen. Effect of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors [J]. Journal of Traditional Chinese Medicine, 2016, 36(04): 450-455. |
| [5] | Junping Wei, Rui Wu, Dandan Zhao. Analysis on Traditional Chinese Medicine syndrome elements and relevant factors for senile diabetes [J]. Journal of Traditional Chinese Medicine, 2013, 33(04): 473-478. |
| [6] | Juan Rodríguez-Mansilla, María Victoria González-LópezArza, Enrique Varela-Donoso, Jesús Montanero-Fernández, María Jiménez-Palomares, Elisa Maria Garrido-Ardila. Ear therapy and massage therapy in the elderly with dementia: a pilot study [J]. Journal of Traditional Chinese Medicine, 2013, 33(04): 461-467. |
| [7] | Lili Hou, Cuiping Chen, Lei Xu, Peihao Yin, Wen Peng. Electrical stimulation of acupoint combinations against deep venous thrombosis in elderly bedridden patients after major surgery [J]. Journal of Traditional Chinese Medicine, 2013, 33(02): 187-193. |
| [8] | Li Jian Sheng , Hou Zheng Kun , Yu Xue Qing , Li Su Yun , Sun Zi Kai , Zhang Wei , Jia Xin Hua , Zheng Si Ping , Wang Ming Hang , Wang Hai Feng. Prognostic factors for community-acquired pneumonia in middle-aged and elderly patients treated with integrated medicine [J]. Journal of Traditional Chinese Medicine, 2012, 32(02): 179-186. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
