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Journal of Traditional Chinese Medicine ›› 2013, Vol. 33 ›› Issue (03): 325-333.DOI: 10.1016/s0254-6272(13)60174-0

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Polyphyllin I inhibits proliferation and metastasis of ovarian cancer cell line HO-8910PM invitro

Linhui Gu, Jianguo Feng, Haiyan Xu, Min Luo, Dan Su   

  1. Cancer Research Institute, Zhejiang Cancer Hospital;
  • Accepted:2013-06-15 Online:2013-06-15 Published:2013-06-15

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Abstract: OBJECTIVE: To study the anticancer mechanism of polyphyllin I (PPI), a Traditional Chinese Medicine, on the ovarian cancer cell line HO-8910PM invitro. METHODS: Transwell chamber invasive assays were used to investigate the inhibitory capacity of PPI on HO-8910PM metastasis. Gene expression profiling chips was used to screen differentially expressed genes between experiment group and control group. Reverse transcription PCR and Western blotting were used to determine mRNA and protein levels. RESULTS: With increasing PPI concentration, the metastatic capacity of cells decreased, with significance differences between the experimental and control groups (P

Key words: Chonglou Saponin I, Ovarian Neoplasms, Apoptosis, Cell Movement

Cite this article

Linhui Gu, Jianguo Feng, Haiyan Xu, Min Luo, Dan Su. Polyphyllin I inhibits proliferation and metastasis of ovarian cancer cell line HO-8910PM invitro[J]. Journal of Traditional Chinese Medicine, 2013, 33(03): 325-333.