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Journal of Traditional Chinese Medicine ›› 2016, Vol. 36 ›› Issue (04): 522-529.

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Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica

Zhao Chongjun, Tian Jinghuan, Wang Jinfeng, Feng Yaru, Ni Yuanyuan, Fan Jiaojiao, Wang Chunmei, Cao Dan, Zou Qinwen, Ma Zhiqiang, Lin Ruichao   

  1. School of Chinese Materia Medica,Bejing University of Chinese Medicine,Beijing Key Laborator for Quality Evalution of Traditional Chinese Medicine;New drug research and Development Department of Beijing Kowloon Pharmaceutical Co.,Ltd.;Department of quality of control of Beijing lianxin Pharmaceutic Co.,Ltd.;
  • Accepted:2016-08-15 Online:2016-08-15 Published:2022-04-05

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Abstract: OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine.

Key words: Zebrafish, Strychnos nux-vomica, Toxicity

Cite this article

Zhao Chongjun, Tian Jinghuan, Wang Jinfeng, Feng Yaru, Ni Yuanyuan, Fan Jiaojiao, Wang Chunmei, Cao Dan, Zou Qinwen, Ma Zhiqiang, Lin Ruichao. Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica[J]. Journal of Traditional Chinese Medicine, 2016, 36(04): 522-529.