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Journal of Traditional Chinese Medicine ›› 2014, Vol. 34 ›› Issue (04): 419-429.DOI: 10.1016/S0254-6272(15)30041-8

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Effect of curcumin on rats/mice with diabetic nephropathy: a systematic review and Meta-analysis of randomized controlled trials

Wei Wu, Hua Geng, Zhaoru Liu, Hong Li, Zhangzhi Zhu   

  1. Institute of Diabetes, the First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine;Department of Endocrine,the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine;
  • Accepted:2014-08-15 Online:2014-08-05 Published:2022-04-05

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Abstract: OBJECTIVE: To assess the renal protective effects of curcumin administration ondiabetic rats/mice.METHODS: Databases were searched electronically and conference papers searched manually for search terms to find relevant studies. Articles were assessed independently by two reviewers. Review Manager 5.1 was used fordata analysis.RESULTS: Fourteen randomized controlled experiments were included. Meta-analysis demonstrated that blood sugar levels and kidney weight to body weight ratios in the model group were higher than those in the normal group, and the curcumin group had significantly lower mesangial area to glomerular area ratios compared with the model group, and also lower levels of urinary protein,blood urea nitrogen and serum creatinine.CONCLUSION: Curcumin shows protective effects on the kidneys of rats/mice with diabetes.

Key words: Curcumin, Diabetic nephropathies, Meta-analysis, Review, Randomized controlled trials

Cite this article

Wei Wu, Hua Geng, Zhaoru Liu, Hong Li, Zhangzhi Zhu. Effect of curcumin on rats/mice with diabetic nephropathy: a systematic review and Meta-analysis of randomized controlled trials[J]. Journal of Traditional Chinese Medicine, 2014, 34(04): 419-429.