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Journal of Traditional Chinese Medicine ›› 2014, Vol. 34 ›› Issue (03): 317-323.DOI: 10.1016/S0254-6272(14)60096-0

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Antidepressant effects of Radix et Caulis Acanthopanacis Santicosi extracts on rat models with depression in terms of immobile behavior

Bhaktaprasad Gaire, Dongwook Lim   

  1. Gaire, Department of Pharmacology, College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University Incheon 406-799, Republic of Korea;Functionality Evaluation Research Group,Korea Food Research Institute,Seongnam463-746,Republic of Korea;
  • Accepted:2014-06-15 Online:2014-06-15 Published:2022-04-05

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Abstract: OBJECTIVE: To investigate the antidepressant effects of the Radix et Caulis Acanthopanacis Santicosi extracts in response to the tail suspension test(TST)and forced swim test (FST) in rats.METHODS:Male Wistar rats (9-week-old) wereorally administered the Radix et Caulis Acanthopanacis Santicosi extracts(30, 100 and 300 mg/kg) daily for 14 consecutive days. Serum corticosterone level was measured by using commercially available kit.The c-fos immunoreactivity was analyzed using immunohistochemistry methods.RESULTS:The effect of Radix et Caulis Acanthopanacis Santicosi extracts on the immobility time was significantly decreased at high-dose(300 mg/kg)treated group in the TST and FST(47.7%and69.6%,P

Key words: Acanthopanax senticosus, Antidepressive agents, Stress, Behavior

Cite this article

Bhaktaprasad Gaire, Dongwook Lim. Antidepressant effects of Radix et Caulis Acanthopanacis Santicosi extracts on rat models with depression in terms of immobile behavior[J]. Journal of Traditional Chinese Medicine, 2014, 34(03): 317-323.