Abstract: INTRODUCTION: Diabetic kidney disease(DKD) is one of the most common microvascular complications of diabetes mellitus and is the leading cause of end-stage renal disease. DKD seriously affects the quality of life of patients and brings heavy economic burden to the country. At present, the pathogenesis of DKD is not entirely clear, and clinical treatment is mainly to control blood glucose and lower blood pressure and urine protein. However,the clinical effect is not satisfactory.CASE PRESENTATION: A female patient, aged 72 years, first visited our hospital endocrinology clinic,and was diagnosed with DKD. She suffered from fatigue, cold sensation in the lower extremities, convulsion of the lower limbs and frequent urination at night. She had a dark purple tongue with white and yellow fur and sublingual varices. Accessory examinations showed that her fasting blood glucose was 5.7 mmol/L, serum creatinine 159 μmol/L,blood urea nitrogen 13.6 μmol/L, blood uric acid493 μmol/L, and blood pressure 138/65 mm Hg.The patient received Traditional Chinese Medicine treatment of the modified Shenzhuo formula[Huangqi(Radix Astragali Mongolici), Dahuang(Radix Et Rhizoma Rhei Palmati), Shuizhi(Hirudo) and Danshen(Radix Salviae Miltiorrhizae)] for 7 years and achieved good results.CONCLUSION: This case provides a specific treatment plan and an effective reference for clinical application of Traditional Chinese Medicine for treating DKD. This may be an alternative treatment for DKD.

Key words: Diabetic nephropathies, Medicine,Chinese traditional, Shenzhuo formula, Case reports