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Journal of Traditional Chinese Medicine ›› 2018, Vol. 38 ›› Issue (04): 579-584.

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Fuxin decoction attenuates doxorubicin-induced heart failure in rats via oxidizing suppression and regulating immune responses

Guo Yuhong, Di Tingting, Zhao Jingxia, Xu Xiaolong, Li Ping, Huang Lijuan, Liu Qingquan   

  1. Intensive Care Unit,Beijing Hospital of Traditional Chinese Medicine,Affiliated with Capital Medical University;Beijing Institute of Traditional Chinese Medicine,Beijing Hospital of Traditional Chinese Medicine,Affiliated with Capital Medical University;
  • Online:2018-08-15 Published:2018-08-15
  • Supported by:
    grants from clinical-scientific research program of Capital Medical University(No.16JL74), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No.ZYLX201611)

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Abstract: OBJECTIVE:To observe the effects of Fuxin decoction in rats with heart failure induced by doxorubicin injections.METHODS:We employed a doxorubicin-induced heart failure model to investigate the effect of Fuxin decoction.Rats were orally administered with Fuxin decoction from 10 to 40 mg/kg.Organization structure changes were assessed by histology,circulating levels of oxidative stress-related biomarkers and inflammatory cytokines were detected via enzyme-linked immunosorbent assay.RESULTS:Administration of Fuxin decoction improved the growth retardation in doxorubicin hydrochloride injection rats.Cardiac involvement was alleviated by Fuxin decoction,as well as changes of congestion systemic circulation in this rat models.Furthermore,Fuxin decoction regulates immune responses and suppresses oxidation reaction in doxorubicin hydrochloride-induced rats.CONCLUSION:Fuxin decoction might be an interesting candidate for congestive heart failure.

Key words: Fuxin decoction, Doxorubicin, Congestive heart failure, Oxidizing suppression, Immune regulation

Cite this article

Guo Yuhong, Di Tingting, Zhao Jingxia, Xu Xiaolong, Li Ping, Huang Lijuan, Liu Qingquan. Fuxin decoction attenuates doxorubicin-induced heart failure in rats via oxidizing suppression and regulating immune responses[J]. Journal of Traditional Chinese Medicine, 2018, 38(04): 579-584.