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Journal of Traditional Chinese Medicine ›› 2018, Vol. 38 ›› Issue (02): 211-217.

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Inhibitory effect of Sumu(Lignum Sappan) plus Fuzi(Radix Aconiti Lateralis Praeparata) on a lung carcinoma model

Zhang Hewei, Ma Shuran, Tian Tian, Xu Ya, Zhao Dandan, Wang Tong, Hou Chunying, Zhang Shujing   

  1. College of Traditional Chinese Medicine,Beijing University of Chinese Medicine;
  • Online:2018-04-15 Published:2018-04-15
  • Supported by:
    Supported by Beijing University of Chinese Medicine Fundamental Research Funds for Young and Middle-aged Teachers in 2015(No.2015-JYB-JSMS006)

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Abstract: OBJECTIVE: To investigate the inhibitory effect of Sumu(Lignum Sappan) plus Fuzi(Radix Aconiti Lateralis Praeparata)(SF) on the growth and metastasis of Lewis lung carcinoma.METHODS: A lung carcinoma model was established by subcutaneously inoculating Lewis lung carcinoma cells into C57 BL/6 mice. The mice were randomly divided into four groups of 13 mice(control, low-dose, moderate-dose, and high-dose), and gavaged once-daily for 21 consecutive days. The rates of tumor inhibition, metastasis, and metastasis inhibition were observed. The differential expressions of s P-selectin and vascular endothelial growth factor C(VEGFC) were compared between the treatment groups and the control group.RESULTS: The tumor weights differed significantly between the treatment groups and the control group(P < 0.05). Administration of SF in the moderate-dosage and low-dose groups significantly inhibited the expression of s P-selectin and VEGFC(both P < 0.05), suggesting anti-tumor activity.CONCLUSION: SF can inhibit the growth and metastasis of Lewis lung carcinoma.

Key words: Carcinoma,Lewis lung, Blood stasis, Sumu(Lignum Sappan), Fuzi(Radix Aconiti Lateralis Praeparata)

Cite this article

Zhang Hewei, Ma Shuran, Tian Tian, Xu Ya, Zhao Dandan, Wang Tong, Hou Chunying, Zhang Shujing. Inhibitory effect of Sumu(Lignum Sappan) plus Fuzi(Radix Aconiti Lateralis Praeparata) on a lung carcinoma model[J]. Journal of Traditional Chinese Medicine, 2018, 38(02): 211-217.