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Journal of Traditional Chinese Medicine ›› 2019, Vol. 39 ›› Issue (01): 15-25.DOI: 10.19852/j.cnki.jtcm.2019.01.002

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Extracts from Paeonia lactiflora Pallas, Rehmannia Glutinosa var. Purpurea Makino, Perilla Frutescens var. Acuta Kudo may increase the endometrial receptivity through expression of leukemia inhibitory factor and adhesion molecules

Eun-Yeong Kim, Tae-Wook Chung, Hee-Jung Choi, Yeon-Seop Jung, Syng-Ook Lee, Jun-Yong Choi, Hyung Sik Kim, Sooseong You, Myeong Soo Lee, Ki-Tae Ha   

  1. School of Korean Medicine and Korean Medical Research Center for Healthy Aging, Pusan National University;Graduate Training Program of Korean Medicine for Healthy-aging, Pusan National University;Department of Food Science and Technology, Keimyung University;National Clinical Research Center for Korean Medicine, Korean Medicine Hospital of Pusan National University;Laboratory of Molecular Toxicology,School of Pharmacy, SungKyunKwan University;Korea Institute of Oriental Medicine;
  • Online:2019-02-15 Published:2019-02-15
  • Supported by:
    the National Research Foundation of Korea(NRF)grant funded by the Ministry of Science and ICT(MIST), Korea Government(No.2014R1A5A20009936), by a grant of the Traditional Korean Medicine R&D Project,Ministry of Health&Welfare(No.HI13C0502)

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Abstract: OBJECTIVE: To find out the combination of the extracts from Paeonia lactiflora Pallas(PL), Rehmannia Glutinosa var. Purpurea Makino(RG), Perilla Frutescens var. Acuta Kudo(PF) to increase endometrial receptivity.METHODS: Herbal medicines were extracted with boiling water and polysaccharides were removed.We examined the effect of PL, RG, and PF(PRP), a most effective herbal formula deduced from constitutive ingredient herbs of Antai Yin which is composed of PRP, on the leukemia inhibitory factor(LIF) expression and endometrial receptivity.RESULTS: The combination of the extracts from PRP induced the LIF expression in Ishikawa cells and increased the adhesion between Ishikawa and JAr cells. In addition, PRP-induced attachment of JAr cells onto Ishikawa cells and expression of adhesion molecules, ITGAV, ITGB5, CD44 s, and Lselectin, are significantly reduced by knock-down of LIF expression.CONCLUSION: Induced by the combination of the PRP extracts, the adhesion between trophoblast and endometrial cells are mediated by expression of LIF and adhesion molecules. Thus, we suggest the combination of the PRP extracts may be a novel therapy for enhancing embryo implantation rate.

Key words: Paeonia, Rehmannia, Perilla, Embryo implantation, Endometrium, Leukemia inhibitory factor, Cell adhesion molecules

Cite this article

Eun-Yeong Kim, Tae-Wook Chung, Hee-Jung Choi, Yeon-Seop Jung, Syng-Ook Lee, Jun-Yong Choi, Hyung Sik Kim, Sooseong You, Myeong Soo Lee, Ki-Tae Ha. Extracts from Paeonia lactiflora Pallas, Rehmannia Glutinosa var. Purpurea Makino, Perilla Frutescens var. Acuta Kudo may increase the endometrial receptivity through expression of leukemia inhibitory factor and adhesion molecules[J]. Journal of Traditional Chinese Medicine, 2019, 39(01): 15-25.