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Journal of Traditional Chinese Medicine ›› 2020, Vol. 40 ›› Issue (6): 1041-1051.DOI: 10.19852/j.cnki.jtcm.2020.06.016

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Cerebral fractional amplitude of low-frequency fluctuations may predict headache intensity improvement following acupuncture treatment in migraine patients

Li Zhengjie, Zhou Jun, Cheng Shirui, Lan Lei, Sun Ruirui, Liu Mailan, Yang Jie, Gao Yujie, Guo Taipin, Gong Qiyong, Zeng Fang, Liang Fanrong   

  1. Acupuncture & Tuina School/The Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine;Acupuncture & Tuina School, Hunan University of Chinese Medicine;Huaxi Magnetic Resonance Research Center,West China Hospital of Sichuan University;
  • Online:2020-12-25 Published:2020-12-25
  • Supported by:
    Supported by Project of National Natural Science Foundation of China Benefits Prediction of Acupuncture Treatment for Migraine Based on Neural Radiomic and COMT Gene Polymorphism (No. 81973958), the Modulation Effect of Acupuncture Treatment for the Descending Pain Modulation System in Knee Pain Patients Based on Double Dummy Design (No. 81603708), the Modulation of Acupuncture on the Pain-cognitive Control Network Of Knee Osteoarthritis Patient (No. 81774400), Project of National Natural Science Foundation of China Acupoints Sensibilization Research(No. 81590950), Project of China Postdoctoral Science Foundation Neuroimaging Study of the Clinical Benefits Prediction of Acupuncture and Celecoxib Treatment for Knee Pain(No. 20190037), Prediction Research of Acupuncture Treatment Efficacy for Chronic Pain (No. 2018T110954), The Modulation Effect of Acupuncture Treatment for Cerebral Cognitive Control Network in Knee Pain Patients (No.2017M610593), Key Project of Sichuan Provincial Education Department The Modulation Effect of Acupuncture Treatment for Pain Modulation Network in Knee Pain Patients(No. 17ZA0157)

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Abstract: OBJECTIVE: To explore how baseline resting-state cerebral function predicts clinical outcomes of acupuncture treatment for migraine.METHODS: One hundred migraine patients and 46 healthy subjects were recruited. Patients were randomized into the acupuncture, sham acupuncture,and waiting list groups. Resting-state functional magnetic resonance imaging data were collected at baseline and after 1 month of longitudinal acupuncture treatments. Fractional amplitude of low-frequency fluctuations(f ALFF) calculations were applied to explore the associations between baseline f ALFF and changes in clinical variables in the acupuncture treatment group and the waiting list group.RESULTS: Compared with healthy subjects, migraine patients had lower f ALFF in the left rostral ventromedial medulla, right thalamus, left amygdala, and right angular gyrus. Regression analyses revealed that baseline f ALFF values in the left middle frontal gyrus, left superior temporal gyrus, and middle temporal gyrus were positively associated with headache intensity changes in the acupuncture treatment group, while baseline f ALFF values in the bilateral lingual gyrus and cuneus were negatively associated with headache intensity changes in this group.CONCLUSION: The baseline f ALFF values of brain regions associated with cognitive pain modulation,but not migraine severity, may predict future headache intensity improvement levels in migraine patients receiving acupuncture treatment.

Key words: Acupuncture, Migraine disorders, Treatment outcome, Magnetic resonance imaging

Cite this article

Li Zhengjie, Zhou Jun, Cheng Shirui, Lan Lei, Sun Ruirui, Liu Mailan, Yang Jie, Gao Yujie, Guo Taipin, Gong Qiyong, Zeng Fang, Liang Fanrong. Cerebral fractional amplitude of low-frequency fluctuations may predict headache intensity improvement following acupuncture treatment in migraine patients[J]. Journal of Traditional Chinese Medicine, 2020, 40(6): 1041-1051.