Journal of Traditional Chinese Medicine ›› 2026, Vol. 46 ›› Issue (4): 864-872.DOI: 10.19852/j.cnki.jtcm.2026.04.007
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Effects of Biling Weitong granules (荜铃胃痛颗粒) on gastrointestinal motility and gastrointestinal hormones levels in rats with functional dyspepsia
GAO Lige1, LI Xueyi2, CHEN Feiyu3, JIANG Changyu4, LI Jiadi5(
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- 1
Clinical Pharmacy ,Affiliated Hospital of Hebei Engineering University Handan 056000, China
2Clinical Pharmacy ,Qiqihar Medical University Qiqihar 161000, China
3Department of Pharmacy ,First Affiliated Hospital of Qiqihar Medical College Qiqihar 161041, China
4Department of Gastroenterology ,First Affiliated Hospital of Qiqihar Medical College Qiqihar 161041, China
5Clinical Pharmacy ,First Affiliated Hospital of Qiqihar Medical College Qiqihar 161041, China
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Received:2025-06-15Accepted:2025-11-11Online:2026-08-15Published:2026-08-08 -
Contact:Prof. LI Jiadi, Clinical Pharmacy, First Affiliated Hospital of Qiqihar Medical College, Qiqihar 161041, China. lijiadiqqbb@126.com,Telephone: +86-13359521521
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Supported by:Heilongjiang Provincial Health Commission Project: Effectiveness and safety evaluation of Biling Weitong Granules for Treating Functional Dyspepsia(20220303030646)
Cite this article
GAO Lige, LI Xueyi, CHEN Feiyu, JIANG Changyu, LI Jiadi. Effects of Biling Weitong granules (荜铃胃痛颗粒) on gastrointestinal motility and gastrointestinal hormones levels in rats with functional dyspepsia[J]. Journal of Traditional Chinese Medicine, 2026, 46(4): 864-872.
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Table 1 Changes in body weight of rats in each group (g, $\bar{x}±s$)
| Group | n | Before modeling | After modeling |
|---|---|---|---|
| BG | 5 | 99±8 | 180±28a |
| MG | 5 | 99±8 | 136±11ab |
Table 1 Changes in body weight of rats in each group (g, $\bar{x}±s$)
| Group | n | Before modeling | After modeling |
|---|---|---|---|
| BG | 5 | 99±8 | 180±28a |
| MG | 5 | 99±8 | 136±11ab |
Table 2 Changes of body weight of rats in each group (g, $\bar{x}±s$)
| Group | n | Body weight |
|---|---|---|
| BG | 7 | 312±38 |
| MG | 7 | 221±16a |
| BL | 7 | 244±16bc |
| BM | 7 | 266±29d |
| BH | 7 | 298±31d |
| TM | 7 | 283±31d |
Table 2 Changes of body weight of rats in each group (g, $\bar{x}±s$)
| Group | n | Body weight |
|---|---|---|
| BG | 7 | 312±38 |
| MG | 7 | 221±16a |
| BL | 7 | 244±16bc |
| BM | 7 | 266±29d |
| BH | 7 | 298±31d |
| TM | 7 | 283±31d |
Figure 1 Comparison of food intake of rats in each group BG and MG groups: fed only with 2 mL distilled water; BL group: treated with 0.68 g/kg; BM group: treated with 1.35 g/kg; BH group: treated with 2.70 g/kg; TM group: treated with 0.03 g/kg; BG group: blank group; MG group: model group; BL group: Biling Weitong granules low-dose group; BM group: Biling Weitong granules middle-dose group; BH groups: Biling Weitong granules high-dose group; TM group: trimebutine maleate group. t tests and analysis of variance were used for comparisons. Data are presented as mean ± standard deviation (n = 7). Compared with the MG group, aP < 0.05; compared with the TM group, bP < 0.05; compared with the BG group, cP < 0.05.
Figure 1 Comparison of food intake of rats in each group BG and MG groups: fed only with 2 mL distilled water; BL group: treated with 0.68 g/kg; BM group: treated with 1.35 g/kg; BH group: treated with 2.70 g/kg; TM group: treated with 0.03 g/kg; BG group: blank group; MG group: model group; BL group: Biling Weitong granules low-dose group; BM group: Biling Weitong granules middle-dose group; BH groups: Biling Weitong granules high-dose group; TM group: trimebutine maleate group. t tests and analysis of variance were used for comparisons. Data are presented as mean ± standard deviation (n = 7). Compared with the MG group, aP < 0.05; compared with the TM group, bP < 0.05; compared with the BG group, cP < 0.05.
Figure 2 Comparison of gastric emptying rates A and small intestinal propulsion rates B between groups of rats A: comparison of gastric emptying rates; B: small intestinal propulsion rates. BG and MG groups: treated by gavage at a dose of 3 mL·kg-1·d-1. BL group: treated with 0.68 g/kg. BM group: treated with 1.35 g/kg. BH group: treated with 2.70 g/kg; TM group: treated with 0.03 g/kg; BG group: blank group; MG group: model group; BL group: Biling Weitong granules low-dose group; BM group: Biling Weitong granules middle-dose group; BH group: Biling Weitong granules high-dose group; TM group: trimebutine maleate group. t tests and analysis of variance were used for comparisons. Data are presented as means ± standard deviations (n = 7). Compared with the BG group, aP < 0.01; compared with the MG group, bP < 0.01; compared with the TM group, cP < 0.01.
Figure 2 Comparison of gastric emptying rates A and small intestinal propulsion rates B between groups of rats A: comparison of gastric emptying rates; B: small intestinal propulsion rates. BG and MG groups: treated by gavage at a dose of 3 mL·kg-1·d-1. BL group: treated with 0.68 g/kg. BM group: treated with 1.35 g/kg. BH group: treated with 2.70 g/kg; TM group: treated with 0.03 g/kg; BG group: blank group; MG group: model group; BL group: Biling Weitong granules low-dose group; BM group: Biling Weitong granules middle-dose group; BH group: Biling Weitong granules high-dose group; TM group: trimebutine maleate group. t tests and analysis of variance were used for comparisons. Data are presented as means ± standard deviations (n = 7). Compared with the BG group, aP < 0.01; compared with the MG group, bP < 0.01; compared with the TM group, cP < 0.01.
Figure 3 Comparison of serum MTL A and VIP B contents of rats in each groups A: MTL level; B: VIP level. BG, MG, BL, BM, BH, TM groups: prepared according to 50 μL (25 μL serum +25 μL dilution). BG group: blank group; MG group: model group; BL group: Biling Weitong granules low-dose group; BM group: Biling Weitong granules middle-dose group; BH group: Biling Weitong granules high-dose group; TM group: trimebutine maleate group. t tests and analysis of variance were used for comparisons. Data are presented as mean ± standard deviation (n = 7). Compared with the BG group, aP < 0.01; compared with the MG group, bP < 0.01; compared with the TM group, cP < 0.01
Figure 3 Comparison of serum MTL A and VIP B contents of rats in each groups A: MTL level; B: VIP level. BG, MG, BL, BM, BH, TM groups: prepared according to 50 μL (25 μL serum +25 μL dilution). BG group: blank group; MG group: model group; BL group: Biling Weitong granules low-dose group; BM group: Biling Weitong granules middle-dose group; BH group: Biling Weitong granules high-dose group; TM group: trimebutine maleate group. t tests and analysis of variance were used for comparisons. Data are presented as mean ± standard deviation (n = 7). Compared with the BG group, aP < 0.01; compared with the MG group, bP < 0.01; compared with the TM group, cP < 0.01
Figure 4 Gastric antrum tissues of rats in each group A: expression of the gastric antrum tissues × 100; B: expression of the gastric antrum tissues × 200; A1, B1: BG group; A2, B2: MG group; A3, B3: BL group; A4, B4: BM group; A5, B5: BH group; A6, B6: TM group. BG and MG groups: treated by gavage at a dose of 3 mL·kg-1·d-1; BL group: treated with 0.68 g/kg; BM group: treated with 1.35 g/kg; BH group: treated with 2.70 g/kg; TM group: treated with 0.03 g/kg; BG group: blank groups; MG group: model group; BL group: Biling Weitong granules low-dose group; BM group: Biling Weitong granules middle-dose group; BH group: Biling Weitong granules high-dose group; TM group: trimebutine maleate group. Dyeing method of all pictures are hematoxylin and eosin staining.
Figure 4 Gastric antrum tissues of rats in each group A: expression of the gastric antrum tissues × 100; B: expression of the gastric antrum tissues × 200; A1, B1: BG group; A2, B2: MG group; A3, B3: BL group; A4, B4: BM group; A5, B5: BH group; A6, B6: TM group. BG and MG groups: treated by gavage at a dose of 3 mL·kg-1·d-1; BL group: treated with 0.68 g/kg; BM group: treated with 1.35 g/kg; BH group: treated with 2.70 g/kg; TM group: treated with 0.03 g/kg; BG group: blank groups; MG group: model group; BL group: Biling Weitong granules low-dose group; BM group: Biling Weitong granules middle-dose group; BH group: Biling Weitong granules high-dose group; TM group: trimebutine maleate group. Dyeing method of all pictures are hematoxylin and eosin staining.
| 1. |
Yang NN, Tan CX, Lin LL, et al. Potential mechanisms of acupuncture for functional dyspepsia based on pathophysiology. Front Neurosci 2021; 15: 781215.
DOI URL |
| 2. |
Ho L, Zhong CC, Wong CH, et al. Herbal medicine for functional dyspepsia: network Meta-analysis of placebo-controlled randomised trials. J Ethnopharmacol 2022; 283: 114665.
DOI URL |
| 3. |
Jiang SM, Jia L, Lei XG, et al. Incidence and psychological-behavioral characteristics of refractory functional dyspepsia: a large, multicenter, prospective investigation from China. World J Gastroenterol 2015; 21: 1932-7.
DOI URL |
| 4. |
Stanghellini V, Chan FK, Hasler WL, et al. Gastroduodenal disorders. Gastroenterology 2016; 150: 1380-92.
DOI PMID |
| 5. | Jiang W, Zhou JJ, Cheng H, et al. The mechanism of Hewei-Liqi decoction in the treatment of gastrointestinal motility dysfunction in functional dyspepsia based on stem cell factor (SCF)/c-kit signaling pathway. Guangzhou Zhong Yi Yao Da Xue Xue Bao 2021; 38: 766-73. |
| 6. | Sun ZY, Bi YF, Xie SR, et al. Mechanism of acupuncture in treating FD based on visceral hypersensitivity theory. J Tradit Chin Med 2022; 50: 109-13. |
| 7. |
Wang W, Liu Z, Zhang Y, et al. Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after helicobacter pylori eradication therapy. Front Microbiol 2023; 14: 1288920.
DOI URL |
| 8. | Farcas RA, Grad S, Grad C, et al. Microbiota and digestive metabolites alterations in functional dyspepsia. J Gastrointest Liver Dis 2024; 10: 15403. |
| 9. | Chang Yu, Zhang GS, Han HR, et al. Clinical observation on the brain-gut interaction acupuncture therapy in the treatment of functional dyspepsia with liver-stomach disharmony syndrome complicated with anxiety and depression. Guangzhou Zhong Yi Yao Da Xue Xue Bao 2023; 40: 2814-20. |
| 10. |
Kitazawa T, Kaiya H. Motilin comparative study: structure, distribution, receptors, and gastrointestinal motility. Front Endocrinol (Lausanne) 2021; 12: 700884.
DOI URL |
| 11. | Yuan LX, Hua X, Gang HS. Study on the treatment of reflux esophagitis with Pib B Weitong granules combined with trimebutine and omeprazole. Shi Yong Zhong Xi Yi Jie He Lin Chuang 2021; 21: 23-4. |
| 12. | Zhang SS, Zhao LQ. Expert consensus on Traditional Chinese Medicine diagnosis and treatment of functional dyspepsia (2017). J Tradit Chin Med 2017; 32: 2595-8. |
| 13. |
Wang L, Ding X, Yao X, et al. Efficacy and safety of Xiangsha Liujunzi decoction for functional dyspepsia: a systematic review and Meta-analysis. Front Pharmacol 2024; 15: 1356899.
DOI URL |
| 14. |
Accarie A, Vanuytsel T. Animal models for functional gastrointestinal disorders. Front Psychiatry 2020; 11: 509681.
DOI URL |
| 15. | Zhang C, Zhu GQ, Wang JJ, Li XJ, Li M, Wang XC. Study on the mechanism of acupuncture underlying improvement of functional dyspepsia with depression-like behavior in rats. Zhen Ci Yan Jiu 2025; 50: 76-83. |
| 16. | Wang C, Wang B, Aili M, et al. Effect of artemisia rupestris L extract on gastrointestinal hormones and brain-gut peptides in functional dyspepsia rats. Evid Based Complement Alternat Med 2020: 2528617. |
| 17. |
Zhou Z, Li Y, Ding J, et al. Chronic unpredictable stress induces anxiety-like behavior and oxidative stress leading to diminished ovarian reserve. Sci Rep 2024; 14: 30681.
DOI |
| 18. |
Ding JH, Jin Z, Yang XX, et al. Role of gut microbiota via the gut-liver-brain axis in digestive diseases. World J Gastroenterol 2020; 26: 6141-62.
DOI URL |
| 19. |
Drossman DA, Hasler WL. Rome IV-functional GI disorders: disorders of gut-brain interaction. Gastroenterology 2016; 150: 1257-61.
DOI PMID |
| 20. | Gu ST. Clinical study of Jianpi Liqi Huayu decoction in the treatment of upper abdominal pain syndrome of functional dyspepsia (Qi stagnation and blood stasis type). Tianjin: Tianjin University of Traditional Chinese Medicine, 2023: 1-71. |
| 21. |
Yoon DE, Moon H, Lee IS, Chae Y. Discovering the key symptoms for identifying patterns in functional dyspepsia patients: Doctor's decision and machine learning. Integr Med Res 2025; 14: 101115.
DOI URL |
| 22. | Huang SA. Clinical observation of Qiangwei-Zhishu decoction in the treatment of postprandial distress syndrome of functional dyspepsia (spleen deficiency and Qi stagnation). Chengdu: Chengdu University of Traditional Chinese Medicine 2023; 1-49. |
| 23. |
Choi NR, Jung D, Kim SC, et al. Analysis of network pharmacological efficacy and therapeutic effectiveness in animal models for functional dyspepsia of foeniculi fructus. Nutrients 2023; 15: 1-16.
DOI URL |
| 24. |
Huang A, Lin B, Hu T, Lan J. Unraveling functional dyspepsia: pathophysiological mechanisms, microbiota interactions, and emerging therapeutic strategies. Pathol Res Pract 2025; 272: 156118.
DOI URL |
| 25. | Huang Di (Warring States-Western Han). Huang Di Nei Jing. Beijing: People's Medical Publishing House, 1963: 1. |
| 26. |
Zhou F, Du L, Yu L, Zhang D, Jin H, Li Z. Efficacy and mechanism of Tiaoshu Anshen decoction in treating insomnia with spleen and stomach Qi dysfunction: a retrospective study. Medicine (Baltimore) 2024; 103: e40160.
DOI URL |
| 27. | Li M. Clinical study of Sini Huoxue decoction in the treatment of upper abdominal pain syndrome of functional dyspepsia (Qi stagnation and blood stasis syndrome). Yunnan Zhong Yi Yao Da Xue Xue Bao 2020; 1-38. |
| 28. |
Zhou H, Zhou S, Gao J, et al. Upregulation of bile acid receptor TGR5 and nNOS in gastric myenteric plexus is responsible for delayed gastric emptying after chronic high-fat feeding in rats. Am J Physiol Gastrointest Liver Physiol 2015; 308: G863-73.
DOI URL |
| 29. | Zhao JY, Zheng JS, Cao R. Research progress on TCM disease-syndrome combination model of functional dyspepsia of liver stagnation and spleen deficiency. Beijing Zhong Yi Yao 2023; 42: 1156-60. |
| 30. |
Saeidi M, Hassanzadeh G, Rouhollah F, Mokhtari T. Chronic stress disrupts immune and endocrine axis, inducing persistent behavioral impairments in male rats: in silico and in vivo insights. Neurochem Res 2025; 50: 320.
DOI |
| 31. | Lai XX, Chen LY, SU Bochao, et al. Dynamic observation of TCM symptoms and biological indexes in rats with Qi stagnation and blood stasis syndrome prepared by adrenaline combined with ice water bath. Zhong Guo Zhong Yi Ji Chu Yi Xue Za Zhi 2022; 28: 878-85. |
| 32. | Tang J, Wan J, Shi CY, et al. Pharmacodynamic study of SC-CO 2 extract of Fructus Litseae. Quan Guo Zhong Yi Yao Xue Shu Yan Tao Hui Lun Wen Ji 2010; 169-72. |
| 33. | Zhang L, Wu X, Jing CY, et al. Systematic review and Meta-analysis of Biling Weitong granules in treatment of stomach ache disorder. Zhong Guo Zhong Yao Za Zhi 2023; 48: 2249-59. |
| 34. | Liu M. Basic Research and clinical application of Biling Weitong granules. Zhong Guo Zhong Xi Yi Jie He Xiao Hua Za Zhi 2018; 26: 553-6. |
| 35. | Ren YH, Liu ZJ, Zhu S, et al. Research progress on the chemical components of Coptis Chinensis and its treatment of ulcerative colitis. Xian Dai Zhong Xi Yi Jie He Za Zhi 2024; 33: 1447-54. |
| 36. | Qiao HX, Zhen P, Li XJ, et al. Preliminary study on antibacterial effect of evodiarutaecarpa officinalis extract in vitro. Hebei Bei Fang Xue Yuan Xue Bao 2009; 26: 27-9. |
| 37. | Chai X, Li XL. Study on the anti-gastric ulcer and analgesic effect of alpinia officinarum and cyperus rotundus. J Tradit Chin Med 2023; 51: 38-42. |
| 38. | Cheng LP. Study on functional components and medicinal value mining and mechanism of citrus medicinal resources of immature orange. Wuhan: Huazhong Agricultural University 2020; 1-63. |
| 39. | Hao ZY, Li X, Li L. Experimental study on the effect of emodin on related indicators in rats with functional dyspepsia. Xin Zhong Yi 2017; 49: 1-3. |
| 40. | Fang H, Yan YF, Tao MB, et al. Comparative study on the protective effect of concha arcae and different processed products on acute gastric ulcer in rats. Zhong Yao Yao Li Yu Lin Chuang 2018; 34: 116-21. |
| 41. | Li JS, Lin GB, Chen ZL, et al. Effect of Shengjiang-Youyou decoction on chronic gastritis caused by helicobacter pylori with spleen-stomach damp-heat type. Guangzhou Zhong Yi Yao Da Xue Xue Bao 2019; 36: 787-90. |
| 42. |
Qin LL, Yu M, Yang P, Zou ZM. The rhizomes of atractylodes macrocephala relieve loperamide-induced constipation in rats by regulation of tryptophan metabolism. J Ethnopharmacol 2024; 322: 117637.
DOI URL |
| 43. |
Mori H, Verbeure W, Tanemoto R, et al. Physiological functions and potential clinical applications of motilin. Peptides 2023; 160: 170905.
DOI URL |
| 44. |
Sun X, Huang Y, Zhang YL, Qiao D, Dai YC. Research advances of vasoactive intestinal peptide in the pathogenesis of ulcerative colitis by regulating interleukin-10 expression in regulatory B cells. World J Gastroenterol 2020; 26: 7593-602.
DOI URL |
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