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Journal of Traditional Chinese Medicine ›› 2021, Vol. 41 ›› Issue (5): 739-746.DOI: 10.19852/j.cnki.jtcm.20210203.001

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Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats

XIA Xichao, LI Bin, QIU Ju, TIAN Gang, CHEN Changdong, LA Ming, ZHANG Ke, QI Jinxu, LI Yanyan, GAO Huashan, SHAO Xiangyang, SU Congying, WANG Mengqi, OUYANG Jingfeng   

  1. Medical College, Pingdingshan University;College of Chemistry and Chemical Engineering, Pingdingshan University;Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences;
  • Online:2021-10-12 Published:2021-10-15
  • Supported by:
    Supported by the Natural Science Foundation of Henan (Effect of Cyclocarya Paliurus Polysaccharides on the Diabetes Mellitus, No. 182300410123)

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Abstract: OBJEVTIVE: To investigate the effects of Cyclocarya paliurus(C. paliurus) polysaccharides on the spleen injury of diabetic rats.METHODS: Animals were divided into 6 groups, including normal group, model group, control group,low-dose group of C. paliurus polysaccharides treatment, middle-dose group of C. paliurus polysaccharides treatment and high-dose group of C. paliurus polysaccharides treatment. Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7) and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS: Compared with that of model group, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase level increased 78.63%(P < 0.05), 51.76%(P < 0.05), 2.95 times(P < 0.01)and 41.11%(P < 0.05) in the high-dose group of C.paliurus polysaccharides treatment, respectively.IL-7 and IL-10 increase 1.66(P < 0.01) and 1.21 times(P < 0.01) in the high-dose group of C. paliurus polysaccharides treatment, respectively.CONCLUSION: It is suggested that C. paliurus polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity.

Key words: spleen, diabetes mellitus, antioxidants, polysaccharides, Cyclocarya paliurus

Cite this article

XIA Xichao, LI Bin, QIU Ju, TIAN Gang, CHEN Changdong, LA Ming, ZHANG Ke, QI Jinxu, LI Yanyan, GAO Huashan, SHAO Xiangyang, SU Congying, WANG Mengqi, OUYANG Jingfeng. Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats[J]. Journal of Traditional Chinese Medicine, 2021, 41(5): 739-746.