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Journal of Traditional Chinese Medicine ›› 2021, Vol. 41 ›› Issue (6): 985-993.DOI: 10.19852/j.cnki.jtcm.2021.06.017

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Effectiveness of herb-partitioned moxibustion combined with electroacupuncture on polycystic ovary syndrome in patients with symptom pattern of kidney deficiency and phlegm-dampness

ZHAO Qingyi, SUN Yi, ZHOU Jing, GAO Yanling, MA Guizhi, HU Zhihai, WANG Yi, SHI Yin   

  1. Graduate School,Shanghai University of Traditional Chinese Medicine;Department of Acupuncture and Moxibustion, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine;Key Laboratory of Acupuncture and Immunological Effects, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine;Outpatient Department, Shanghai Research Institute of Acupuncture and Meridian;
  • Online:2021-12-07 Published:2021-12-07
  • Supported by:
    Supported by Project of Shanghai Municipal Commission of Health and Family:Study on the Mechanism of Acupuncture and Moxibustion on Follicular Dysplasia and Hyperandrogen Induced by Anti-mullerian Hormone Overexpression in Polycystic Ovary Syndrome (No. 201840307), Shanghai Sailing Program:Study on the Mechanism of Electroacupuncture Regulating Mitochondrial Oxidative Stress Damage and Promoting the Development of Polycystic Ovary Syndrome Oocytes through Sirt3 (No. 20yf1445800), Chinese Medicine Scientific Research Project of Shanghai Municipal Health Commission:Study on the Mechanism of Electroacupuncture at Guanyuan and Zhongji Points on Follicle Development Disturbance Caused by Oocyte Mitochondrial Oxidative Stress Damage in Polycystic Ovary Syndrome (No.2020jq004), Scientific Research Project of Traditional Chinese Medicine of Shanghai Hongkou District Health Committee:Study on the Effect of Electroacupuncture on the Improvement of Follicular Development Disorders and Hyperandrogenism by Regulating the Disturbance of Intestinal Flora in Polycystic Ovary Syndrome (No. HKQ-ZYY-2020-34)

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Abstract: OBJECTIVE:To observe the effect of herb-partitioned moxibustion combined with electroacupuncture on polycystic ovary syndrome(PCOS) in patients with symptom pattern of kidney deficiency and phlegm-dampness.METHODS:Totally 62 PCOS patients who met the inclusion criteria were randomly divided into intervention group and control group. In the intervention group, acupoints were subjected to(43 ± 1) ℃herb-partitioned moxibustion and electroacupuncture treatment. In the control group, acupoints were subjected to(37 ± 1) ℃ herb-partitioned moxibustion and sham electroacupuncture treatment.Treatment was provided 3 times per week for 12 weeks, and the treatment was stopped during menstruation. After the treatment, the clinical efficacy,the Traditional Chinese Medicine(TCM) symptom pattern score, basal body temperature(BBT) levels,menstrual cycle, and related sex hormone levels of the two groups were evaluated.RESULTS:Sixty patients were eventually included in the study(30 in the intervention group and 30 in the control group). There were not obvious between-group differences in the baseline efficacy parameters(all P > 0.05).(a) After treatment, the two groups have improved in terms of clinical efficacy,TCM symptom pattern score, menstrual cycle and,BBT(P < 0.01, < 0.05), and the intervention group was better than the control group(P < 0.01, < 0.05).(b) In the intervention group, the estradiol(E2) and P450 aromatase(P450 arom) levels were increased(all P < 0.05), the testosterone(T) level was decreased(P < 0.05), and the luteotropic hormone(LH) and anti-Müllerian hormone(AMH) levels were significantly decreased(P < 0.01). In the control group, E2 level was increased(P < 0.05), and LH level was decreased(P < 0.05). After treatment, the T,LH, and AMH levels of the intervention group were decreased compared with those of the control group(all P < 0.05), and the P450 arom level was increased(P < 0.05).CONCLUSIONS:Herb-partitioned moxibustion combined with electroacupuncture can effectively improve the related clinical symptoms of PCOS patients with kidney deficiency and phlegm-dampness. Herb-partitioned moxibustion combined with electroacupuncture may inhibit the overexpression of AMH to increase the expression level of P450 arom in ovarian granulosa cells, thereby reconstructing the dependence of follicular development on FSH, and finally improving abnormal follicular development and hyperandrogenism in PCOS patients with kidney deficiency and phlegmdampness.

Key words: moxibustion, electroacupuncture, polycystic ovary syndrome, kidney deficiency and phlegm-dampness

Cite this article

ZHAO Qingyi, SUN Yi, ZHOU Jing, GAO Yanling, MA Guizhi, HU Zhihai, WANG Yi, SHI Yin. Effectiveness of herb-partitioned moxibustion combined with electroacupuncture on polycystic ovary syndrome in patients with symptom pattern of kidney deficiency and phlegm-dampness[J]. Journal of Traditional Chinese Medicine, 2021, 41(6): 985-993.