Abstract: OBJECTIVE:To study the possible role of traditional Chinese medicine(TCM) of Huangqi(Radix Astragali Mongolici), Gancao(Radix Glycyrrhizae), Jinyinhua(Flos Lonicerae), and Lianqiao(Fructus Forsythiae Suspensae) in absorption of lung lesions in Corona Virus Disease 2019(COVID-19) patients.METHODS:A cohort of COVID-19 cases was recruited. During hospitalization, chest computed tomographic(CT) scan and real time polymerase chain reaction(RT-PCR) test were performed every three days. Comparison was held(Western Medicine, WM vs WM plus TCM) on absorption of lung lesions,time interval from admission to negative test result of RT-PCR(ATN), and medical expense. Multivariate cox regression models were built to identify the possible prognostic factor of delayed absorption of lung lesion.RESULTS:The medical expenditure(1163 ± 379 vs1137 ± 498, P = 0.863) and ATN(13 ± 4 vs 10 ± 4, P =0.055) were comparable between cases treated with WM plus TCM and cases only received WM.Multivariate cox regression model showed that cases receiving extra TCM had lower risk of delayed absorption of lung lesions [Hazard ratio = 0.24, 95%confidence Interval(0.06, 0.96), P = 0.043].CONCLUSION:Compared to WM, the treatment of WM plus TCM facilitates the recovery of pulmonary infiltration on COVID-19 cases without significantly increasing medical expense.

Key words: COVID-19, Traditional Chinese Medicine, Western Medicine, Epidemiology, Computed tomography