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Journal of Traditional Chinese Medicine ›› 2021, Vol. 41 ›› Issue (5): 669-676.DOI: 10.19852/j.cnki.jtcm.2021.05.002

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Efficacy of integrated Traditional Chinese Medicine and anti-retroviral therapy on immunological nonresponse in patients with human immunodeficiency virus/acquired immunodeficiency syndrome: a Meta-analysis of randomized controlled trials

TAO Zhuang, HUANG Xiaojie, LIU Ying, WANG Ru, DONG Jipeng, LIANG Biyan, ZOU Wen, GAO Guojian, WANG Zhuo, ZHANG Ke, WU Hao, ZHANG Tong, WANG Jian   

  1. Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences;Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University;Research Center of AIDS Treatment with Traditional Chinese Medicine, China Academy of Chinese Medical Sciences;Center of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences;Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences;Dermatology Department of Qingdao University Hospital;
  • Online:2021-10-12 Published:2021-10-15
  • Supported by:
    Supported by National Science and Technology Major Project of China During the 13th Five-year Plan Period:New Adjuvant Strategies of Traditional Chinese Medicine on Immune Reconstruction for Long-term ART-treated People Living with HIV (No. 2017ZX10205501), Study of AIDS-related Early Biomarkers for Disease Progression and Epidemic Predicting Model (No. 2017ZX10201101), the Beijing Excellent Talent Plan (No. 2018000021223ZK04)

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Abstract: OBJECTIVE: To explore the efficacy of integrating Traditional Chinese Medicine(TCM) and anti-retroviral therapy(ART), a customized combination of different classes of medications which was also called cock-tail treatment, on the immunological nonresponse(INR) in people living with human immunodeficiency virus(HIV)(PLWH).METHODS: Relevant literature in databases such as China National Knowledge Infrastructure Database(CNKI), Wanfang Digital Journal, Chinese Medical Journal Database(CMJD), Chinese Biomedical Literature Database(CBM), Pub Med, Cochrane, and Embase was reviewed by two independent investigators. Data were extracted from the studies according to the eligible criteria and analyzed using Review Manager 5.3.RESULTS: Nine randomized controlled trials(RCTs)with 1078 patients were analyzed. Our analyses showed that CD4 T cell counts in the treatment group improved compared with that in the control group [mean difference(MD) = 13.51, 95% confidence interval(CI): 7.42-19.60, P < 0.0001]. There was no significant difference between the treated and control groups after 3 months(MD = 25.31,95% CI:-2.78 to 53.41, P = 0.08). However, after 6 and 12 months, the response of the treatment group was superior to the control group(MD =27.45, 95% CI: 7.09-47.81, P = 0.008 and MD = 27.34,95% CI: 6.31–48.37, P = 0.01, respectively). The clinical efficacy of the treatment group was also higher than that of the control group(RR = 1.75, 95% CI:1.16-2.65, P = 0.007). However, CD45 RO and CD45 RA T cell counts did not differ significantly between the two groups(MD = 12.37, 95% CI:-6.71 to 31.45, P = 0.20 and MD = 5.67, 95% CI:-3.00 to14.35, P = 0.20, respectively).CONCLUSION: The combined treatment strategy of integrated TCM and Western Medicine promotes long-term reconstitution of the immune system and thus, is beneficial and has potential use for improving INR in PLWH. However, large-scale RCTs are required to provide evidence for optimal intervention strategies.

Key words: Medicine,Chinese Traditional, HIV, acquired immunodeficiency syndrome, immunological nonresponse, anti-retroviral agents, Metaanalysis

Cite this article

TAO Zhuang, HUANG Xiaojie, LIU Ying, WANG Ru, DONG Jipeng, LIANG Biyan, ZOU Wen, GAO Guojian, WANG Zhuo, ZHANG Ke, WU Hao, ZHANG Tong, WANG Jian. Efficacy of integrated Traditional Chinese Medicine and anti-retroviral therapy on immunological nonresponse in patients with human immunodeficiency virus/acquired immunodeficiency syndrome: a Meta-analysis of randomized controlled trials[J]. Journal of Traditional Chinese Medicine, 2021, 41(5): 669-676.