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Journal of Traditional Chinese Medicine ›› 2021, Vol. 41 ›› Issue (3): 414-423.DOI: 10.19852/j.cnki.jtcm.2021.03.009

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Effect of compound Sophorae decoction in the treatment of ulcerative colitis by tissue extract metabolomics approach

HONG Zongchao, CAI Quan, DUAN Xueyun, YANG Yanfang, WU Hezhen, JIANG Nan, FAN Heng   

  1. College of Pharmacy, Hubei University of Chinese Medicine;Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology;Hubei Provincial Hospital of Traditional Chinese Medicine;Hubei Province Academy of Traditional Chinese Medicine;
  • Online:2021-06-03 Published:2021-06-03
  • Supported by:
    Supported by the Chinese National Natural Science Foundation (Immunomodulatory Mechanism of Bmsc Evs Mediated by Ephb2/Ephrin-b1 Pathway in Ulcerative Colitis and Synergistic Effect of Compound Sophorae decoction, No.81774093)

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Abstract: OBJECTIVE: To investigate how compound Sophorae decoction(CSD) works on rats' models of ulcerative colitis(UC) induced by 2,4,6-trinitrobenzenesulfonic acid solution(TNBS) by metabolomics studies of colon, liver, and kidney tissue extracts.METHODS: Rats with UC induced by TNBS enema were used as models in this study. Metabolic profiles of the three tissues were analyzed and pathway analysis of biomarkers was performed after CSD administration and further integration of metabolic networks.RESULTS: Thirteen biomarkers were screened from colon, liver, and kidney tissue extracts, and the levels of these substances were up-or down-regulated in the model group, but their levels were reversed after CSD administration. These biomarkers were mainly related to Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Nicotinate and nicotinamide metabolism,Alanine, aspartate and glutamate metabolism.CONCLUSION: CSD could significantly ameliorate the symptoms of UC by regulating multiple metabolic pathways.

Key words: colitis,ulcerative, metabolomics, trinitrobenzenesulfonic acid, compound Sophorae decoction

Cite this article

HONG Zongchao, CAI Quan, DUAN Xueyun, YANG Yanfang, WU Hezhen, JIANG Nan, FAN Heng. Effect of compound Sophorae decoction in the treatment of ulcerative colitis by tissue extract metabolomics approach[J]. Journal of Traditional Chinese Medicine, 2021, 41(3): 414-423.