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Journal of Traditional Chinese Medicine ›› 2021, Vol. 41 ›› Issue (1): 150-156.DOI: 10.19852/j.cnki.jtcm.2021.01.017

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Traditional Chinese Medicine in the prevention and treatment of stable angina pectoris in patients with coronary heart disease based on the theory of "phlegm and blood stasis" under guidance of evidence-based medicine:a prospective cohort study

CHEN Ying, XIAO Xue, XU Xiaolin, ZHANG Zepeng, DENG Yue   

  1. Department of Cardiology, the Affiliated Hospital to Changchun University of Chinese Medicine;Research Center of Traditional Chinese Medicine, the Affiliated Hospital to Changchun University of Chinese Medicine;Jilin Provincial Key Laboratory of Bio Macromolecules of Chinese Medicine,Changchun University of Chinese Medicine;
  • Online:2021-02-03 Published:2021-06-03
  • Supported by:
    Supported by the National Scientific Research Project of traditional Chinese Medicine Industry: Research on transformation of Key Technologies for prevention and treatment of Coronary heart Disease with Traditional Chinese Medicine (No. 201007001), the State Administration of Traditional Chinese Medicine: the Research of Shenhong Tongluo Granule based on the theory of Fuxie on acute coronary syndrome by proteomics (JDZX2015046)

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Abstract: OBJECTIVE: To ascertain whether continuous treatment with Traditional Chinese Medicine(TCM) combined with standardized drug therapy from Western Medicine can further reduce the incidence of cardiovascular events in patients with coronary heart disease and angina and reduce the incidence of angina pectoris in patients with coronary heart disease.METHODS: A multicenter, prospective cohort study of 1042 patients in 22 hospitals was conducted. A total of 423 patients with angina pectoris were treated with standardized Western Medicine alone(control group) and 619 with a combination of Chinese and Western Medicine(exposure group). The two groups underwent follow-up for 1 year to establish whether there was any improvement in the incidence of cardiovascular events or change in the curative effect.RESULTS: The incidence of primary endpoint events in the combined-exposure group decreased by 0.45%(P > 0.05) and the incidence of secondary terminal events decreased by 5.25% in comparison with the control group(P < 0.05). The total angina pectoris score clearly decreased in the Western Medicine group over the first 6 months, but the decline was more apparent in the combined-exposure group.CONCLUSION: Compared with treatment using standardized Western Medicine alone, providing TCM combined with Western medical treatment reduced the incidence of cardiovascular events in patients with stable angina pectoris(grade Ⅱ endpoint) and effectively improved the curative effect.

Key words: Coronary disease, Angina pectoris, cardiovascular events, Prospective study, Cohort study

Cite this article

CHEN Ying, XIAO Xue, XU Xiaolin, ZHANG Zepeng, DENG Yue. Traditional Chinese Medicine in the prevention and treatment of stable angina pectoris in patients with coronary heart disease based on the theory of "phlegm and blood stasis" under guidance of evidence-based medicine:a prospective cohort study[J]. Journal of Traditional Chinese Medicine, 2021, 41(1): 150-156.