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Journal of Traditional Chinese Medicine ›› 2021, Vol. 41 ›› Issue (1): 26-35.DOI: 10.19852/j.cnki.jtcm.2021.01.004

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Sodium Tanshinone Ⅱ A sulfonate for acute myocardial infarction:a systematic review and Meta-analysis

LIAN Baotao, ZENG Ruixiang, CHEN Yuanfang, LIAO Pengda, GUO Liheng, ZHANG Minzhou   

  1. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine;The Second Clinical College of Guangzhou University of Chinese Medicine;Guangzhou University of Chinese Medicine;
  • Online:2021-02-03 Published:2021-02-03
  • Supported by:
    Supported by Project of Administration of Traditional Chinese Medicine of Guangdong Province Clinical Study of the Effect of TanshinoneⅡA Sodium Sulfonate on Coronary Microcirculation in Patients with Acute Coronary Syndrome(No. 20181126), Project of Special Clinical Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine Clinical Study of the Effect of TanshinoneⅡA Sodium Sulfonate on Coronary Microcirculation in Patients with Acute Coronary Syndrome (No.YN2018QL06), Project of Department of Education of Guangdong Province Acute Myocardial Infarction Chinese Medicine Prevention and Treatment Team (No. 2020KT1207)

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Abstract: OBJECTIVE: To investigate the efficacy and safety of Sodium tanshinone ⅡA sulfonate(STS) plus the conventional treatment on acute myocardial infarction(AMI) patients.METHODS: We searched several electrical databases and hand searched several Chinese medical journals up to January 2019. Randomized controlled trials(RCTs) comparing STS plus conventional treatment with conventional treatment were retrieved.Study screening, data extraction, quality assessment, and data analysis were conducted in accordance with the Cochrane standards.RESULTS: Sixteen trials involving 1383 people were included. The Meta-analysis showed STS combined with conventional treatment was a better treatment option than conventional treatment alone in reducing the risk of mortality, heart failure, arrhythmia and shock. In addition, STS was associated with improvement in left ventricular ejection fraction(LVEF) and left ventricular end diastolic dimension(LVEDD). No significant difference of STS was found on recurrent angina and recurrent AMI. However,the safety of STS remained uncertain for limited data.CONCLUSION: Compared with conventional treatment alone, STS combined with conventional treatment may provide more benefits for patients with AMI. Due to the fact that the overall quality of all included trials is generally low, further large-scale high quality trials are warranted.

Key words: Myocardial infarction, Sodium tanshinone Ⅱ A sulfonate, Systematic review, Metaanalysis

Cite this article

LIAN Baotao, ZENG Ruixiang, CHEN Yuanfang, LIAO Pengda, GUO Liheng, ZHANG Minzhou. Sodium Tanshinone Ⅱ A sulfonate for acute myocardial infarction:a systematic review and Meta-analysis[J]. Journal of Traditional Chinese Medicine, 2021, 41(1): 26-35.