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Journal of Traditional Chinese Medicine ›› 2021, Vol. 41 ›› Issue (5): 753-761.DOI: 10.19852/j.cnki.jtcm.20201023.001

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Blood circulation activating effect of Sanqi(Radix Notoginseng) on venous thromboembolism rats

ZHU Chen, JIANG Huifang, ZHOU Xiaqing, ZHANG Zhirong, WU Yu, FANG Haijun, WANG Lingcong   

  1. Department ICU of the First Affiliated Hospital of Zhejiang Chinese Medical University;Department of Hematology, Tongde Hospital of Zhejiang Province;Department Orthopaedics of the First Affiliated Hospital of Zhejiang Chinese Medical University;Department Dental of the First Affiliated Hospital of Zhejiang Chinese Medical University;
  • Online:2020-10-23 Published:2021-10-15
  • Supported by:
    Supported by Technology Program of Traditional Chinese Medicine of Zhejiang Province (Study on Prevention of Venous Thromboembolism and Intestinal Flora of Sanqi (Radix Notoginseng) in Patients with Intracerebral Hemorrhage in ICU Based on Caprini Score,No. 2019ZQ017), the Natural Sciences Fund of Zhejiang Province (Effect of Curcumin intervention CX3CL1/CX3CR1 Signaling Pathway on Acute Pulmonary Embolism, No. LY17H290006), the Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents science (No. 2014-108)

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Abstract: OBJECTIVE: To explore the blood circulation activating effect and mechanism of Sanqi(Radix Notoginseng) in vivo, using a venous thromboembolism(VTE) rat model.METHODS: We established the VTE rat model, and then intervened with low molecular weight hepa-rin(LMWH), as well as low, medium and high doses of Sanqi(Radix Notoginseng), to observe the blood circulation activating effect of Sanqi(Radix Notoginseng) on VTE rats.RESULTS: After the treatment with high concentrations of Sanqi(Radix Notoginseng), the pulmonary thromboembolism was alleviated, and the lower limb thrombosis was markedly improved. Moreover, the expression quantities of plasma activated partial thromboplastin time, prothrombin time and D-dimer, as well as endothelin, von Willebrand factor, and plasminogen activator inhibitor-1 in thrombosis segment tissues were markedly down-regulated; while those of nitric oxide and tissue-type plasminogen activator were up-regulated. After low and medium concentration Sanqi(Radix Notoginseng) treatment, no obvious improvement was observed in each index. Moreover, the high concentration Sanqi(Radix Notoginseng) showed comparable efficacy to the positive drug LMWH.CONCLUSION: This data suggests that high concentration of Sanqi(Radix Notoginseng) is effective in preventing and treating VTE.

Key words: venous thromboembolism, blood circulation, heparin,low-molecular-weight, Sanqi(Radix Notoginseng)

Cite this article

ZHU Chen, JIANG Huifang, ZHOU Xiaqing, ZHANG Zhirong, WU Yu, FANG Haijun, WANG Lingcong. Blood circulation activating effect of Sanqi(Radix Notoginseng) on venous thromboembolism rats[J]. Journal of Traditional Chinese Medicine, 2021, 41(5): 753-761.