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Journal of Traditional Chinese Medicine ›› 2020, Vol. 40 ›› Issue (5): 875-882.DOI: 10.19852/j.cnki.jtcm.2020.05.018

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Analyses and identification of the chemical constituents of the Uighur formulation Baixuan Xiatare using three-stage infrared spectroscopy

Litipijiang Aibibula, Pang Xiaobo, Zhu Yun, Huang Jian, Wang Hangyu, Gao Le, Liang Xu, Chen Long, Zhang Ke, Wang Jinhui   

  1. Dermatological Department, Hospital of Xinjiang Traditional Uyghur Medicine;School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University;Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine;School of Pharmacy, Shihezi University (Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education);Department of Medicinal Chemistry and Natural Medicine Chemistry (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University;Department of Dermatology, Dongzhimen Hospital, affiliated to Beijing University of Chinese Medicine;
  • Online:2020-10-15 Published:2020-10-15
  • Supported by:
    Supported by National Science and Technology Major Projects for New Drug Development (2017ZX09305005), Scientific Research Funds for High-Caliber Researchers of Shihezi University (RCSX201715)

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Abstract: OBJECTIVE: To identify, rapidly and accurately, the chemical composition of the traditional Uighur formulation Baixuan Xiatare(BXXTR-FU).METHODS: We investigated if application of three-stage infrared(IR) spectroscopy enabled identification of the main chemical constituents(and their origins) in BXXTR-FU.RESULTS: The characteristic peaks of herbal material(s) and BXXTR-FU were assigned. In Fourier transform-IR(FT-IR) spectroscopy of BXXTR-FU, peaks at1616 and 1605 cm-1 of BXXTR-FU were considered to denote anthraquinones and their derivatives;1066 cm-1 was regarded as the characteristic absorption peak of resin glycosides. In second-derivative IR(SD-IR) spectroscopy, the main carbonyl types of BXXTR-FU in the range 1743-1636 cm-1 were assigned: 1651 cm-1 belonged to the carbonyl stretching vibrations of flavonoids and chromones;1717 cm-1 belonged to tannins; 1699 cm-1 belonged to carboxylic acids; 1636 cm-1 belonged to anthraquinones and their derivatives. SD-IR spectroscopy further confirmed that the characteristicabsorption peaks at 1636, 1618 and 1603 cm-1 could be used as markers that BXXTR-FU contained anthraquinones and their derivatives. Synchronous2 D-IR correlation spectra of chemical groups further confirmed the results of FT-IR and SD-IR spectroscopy.CONCLUSION: Our study strongly supported the necessity and importance of three-stage IR spectroscopy owing to its rapid and accurate identification of herbal formulations.

Key words: Spectrum analysis, Absorption peaks, Uighur formulation

Cite this article

Litipijiang Aibibula, Pang Xiaobo, Zhu Yun, Huang Jian, Wang Hangyu, Gao Le, Liang Xu, Chen Long, Zhang Ke, Wang Jinhui. Analyses and identification of the chemical constituents of the Uighur formulation Baixuan Xiatare using three-stage infrared spectroscopy[J]. Journal of Traditional Chinese Medicine, 2020, 40(5): 875-882.