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Journal of Traditional Chinese Medicine ›› 2020, Vol. 40 ›› Issue (5): 827-835.DOI: 10.19852/j.cnki.jtcm.2020.05.013

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Effects of moxibustion and acupuncture at Zusanli(ST 36) and Zhongwan(CV 12) on chronic atrophic gastritis in rats

Liu Mi, Shen Jiacheng, Liu Caichun, Zhong Huan, Yang Qing, Shu Wenna, Ma Mingzhu, Dong Jiyang, Yang Zongbao, Chang Xiaorong, She Chang, Yu Shu   

  1. College of Acupuncture & Moxibustion and Tui-na,Hunan University of Chinese Medicine;Liuyang Hospital of Chinese Medicine;Department of Traditional Chinese Medicine, Department of Electronic Science, Xiamen University;College of Acupuncture & Moxibustion and Tuina, Hunan University of Chinese Medicine;Department of Electronic Science, Fujian Provincial Key Laboratory for Plasma and Magnetic Resonance,Xiamen University;Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital);City University of Hong Kong;
  • Online:2020-10-15 Published:2020-10-15
  • Supported by:
    Supported by the National Key Basic Research Development Plan (973 Plan),China (2015CB554502), the National Natural Science Foundation of China,China (No. 81574082), the Natural Science Foundation of Hunan Province of China,China (2018JJ2295), the Hunan Province University Innovation Platform Open Fund Project,China (No. 18K066)

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Abstract: OBJECTIVE: To evaluate the effects of moxibustion and acupuncture of Zusanli(ST 36) and Zhongwan(CV 12) acupoints on chronic atrophic gastritis(CAG) in rats, and to study the mechanisms behind their actions.METHODS: Forty-four male Sprague-Dawley rats were induced with CAG by intragastric administration of 40% ethanol combined with free drinking of N-methyl-N′-nitro-N-nitrosoguanidine and irregular feeding for 12 weeks, followed by daily treatment with moxibustion or acupuncture for 2 weeks. Histopathologic examination, Western blotting of cytokines [epidermal growth factor(EGF),EGF receptor(EGFR), extracellular signal-regulated kinase(ERK), phosphorylated ERK(p-ERK)], and1 H NMR-based metabolic profiling of gastric tissues were used to measure changes related to CAG modeling and treatment.RESULTS: Moxibustion and acupuncture at Zusanli(ST 36) and Zhongwan(CV 12) each relieved CAG-induced abnormalities in histopathology and cytokine expression of ERK and p-ERK. Only moxibustion treatment regulated the expression of EGF and EGFR. Metabolites that were increased in gastric tissue by CAG induction(alanine, nicotinamide adenine dinucleotide phosphate, uracil DNA glycosylase, lactate, glycerol and adenosine) were restored to normal levels after moxibustion treatment; acupuncture treatment only normalized the levels of adenosine monophosphate and glycerol.CONCLUSION: Our findings suggest that moxibustion or acupuncture at Zusanli(ST 36) and Zhongwan(CV 12) can significantly improve the condition of CAG in rats. These treatments exert their effects on CAG through different mechanisms.

Key words: Gastritis,atrophic, Moxibustion, Acupuncture, Metabolomics, Proton magnetic resonance spectroscopy

Cite this article

Liu Mi, Shen Jiacheng, Liu Caichun, Zhong Huan, Yang Qing, Shu Wenna, Ma Mingzhu, Dong Jiyang, Yang Zongbao, Chang Xiaorong, She Chang, Yu Shu. Effects of moxibustion and acupuncture at Zusanli(ST 36) and Zhongwan(CV 12) on chronic atrophic gastritis in rats[J]. Journal of Traditional Chinese Medicine, 2020, 40(5): 827-835.